Electrochemical Assay to Quantify the Hydroxyl Radical Scavenging Activity of Medicinal Plant Extracts

A new electrochemical assay has been developed which is based on quantifying the attack of OH^. radicals on a self‐assembled thiol monolayer on electrodes in the presence and absence of antioxidants. The OH^. radicals were produced in Fenton solutions. The radical scavengers diminish the concentration of the OH^. radicals in the Fenton solution, and the extent of thiol layer destruction is monitored with the help of a redox probe in solution, the signal of which is only generated at SAM‐free electrode surface. The results of the electrochemical assay were compared with those of the standard DPPH^. assay. In case of each plant extract, an excellent linear correlation was observed between the radical scavenging activity and the concentration of plant extracts; however, the scavenging properties of different plants strongly differ in the electrochemical and the DPPH^. assay. Since the proposed new method probes the reactivity of radical scavengers towards OH^., one of the most important reactive oxygen radicals in tissues, it is supposed to provide much more relevant information than the DPPH^. or other assays.     

Raman spectroscopy of synthetic organic pigments used in 20th century works of art

Raman microscopy allows a non‐destructive characterisation of inorganic and organic painting materials such as pigments and organic dyestuffs. The objectives of this study are the more recent organic pigments typically present in paintings and other art works from the 20th century. More than 20 organic synthetic pigments from different chemical classes could be identified by Raman spectroscopy using different excitation wavelengths (457.9, 476.5, 487.9, 514.5, 632.8, and 1064 nm). To evaluate the performance for real paint samples, varying paint mixtures of the Hansa Yellow pigment PY 3 and the binding medium Mowilith, a polyvinyl acetate (PVAC) compound, were characterised; PY 3 was determined at a 1 wt% level in the binder. In addition, commercial tube paints containing the quinacridone violet PV 19 were studied. The pigment was clearly identified in all of these more complex oil and acrylic paints. Finally, alizarin (PR 83) and a green copper phthalocyanine pigment (PG 7) could unambiguously be identified by Raman microscopy in the painting ‘Woman with mandolin in yellow and red’ of Max Beckmann dating 1950. The discovery of a red naphthol AS pigment by Raman spectroscopy in a sample from the ‘Three field workers’ by Georg Baselitz (1964/1965) demonstrated that in some cases complementary chromatographic methods are needed for a comprehensive identification of the organic pigments. Copyright © 2008 John Wiley & Sons, Ltd.     

Intelligent driving in traffic systems with partial lane discipline

It is a most common notion in traffic theory that driving in lanes and keeping lane changes to a minimum leads to smooth and laminar traffic flow, and hence to increased traffic capacity. On the other hand, there exist persistent vehicular traffic systems that are characterised by habitual disregarding of lane markings, and partial or complete loss of laminar traffic flow. Here, we explore the stability of such systems through a microscopic traffic flow model, where the degree of lane-discipline is taken as a variable, represented by the fraction of drivers that disregard lane markings completely. The results show that lane-free traffic may win over completely ordered traffic at high densities, and that partially ordered traffic leads to the poorest overall flow, while not considering the crash probability. Partial order in a lane-free system is similar to partial disorder in a lane-disciplined system in that both lead to decreased traffic capacity. This could explain the reason why standard enforcement methods, which rely on continuous increase of order, often fail to incur order to lane-free traffic systems. The results also provide an insight into the cooperative phenomena in open systems with self-driven particles.     

Extending the GGobi pipeline from R

This paper describes progress towards developing a platform for rapid prototyping of interactive data visualizations, using R, GGobi, rggobi and RGtk2. GGobi is a software tool for multivariate interactive graphics. At the core of GGobi is a data pipeline that incrementally transforms data through a series of stages into a plot and maps user interaction with the plot back to the data. The GGobi pipeline is extensible and mutable at runtime. The rggobi package, an interface from the R language to GGobi, has been augmented with a low-level interface that supports the customization of interactive data visualizations through the extension and manipulation of the GGobi pipeline. The large size of the GGobi API has motivated the use of the RGtk2 code generation system to create the low-level interface between R and GGobi. The software is demonstrated through an application to interactive network visualization.