排序方式: 共有65条查询结果,搜索用时 156 毫秒
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Ashraf A. Aly Mohamed Ramadan Mohamed Abd El-Aziz Stefan Bräse Alan B. Brown Hazem M. Fathy Martin Nieger 《Chemical Papers》2017,71(8):1409-1417
N-Arylbenzamidrazones and ethyl 2-cyano-3-ethoxybut-2-enoate reacted together in ethanol and catalyzed by triethylamine (Et3N) to give 5-amino-3-methyl-1-(aryl(phenylimino)methyl)-1H-pyrazole derivatives. Reaction of the target amidrazones with bis-(methylthio)methylidene)malononitrile in EtOH/Et3N/DMF mixture proceeded to give the corresponding 5-aminopyrazoles. The structure of the obtained products was proved by IR, mass, and NMR spectra and elemental analyses. Two-dimensional NMR spectroscopy and X-ray structural analyses were used to differentiate the assigned structures from other possible ring systems and regioisomers. The reaction mechanism is discussed. 相似文献
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Alsaif Nawaf A. Elwan Alaa Alanazi Mohammed M. Obaidullah Ahmad J. Alanazi Wael A. Alasmari Abdullah F. Albassam Hussam Mahdy Hazem A. Taghour Mohammed S. 《Molecular diversity》2022,26(4):1915-1932
Molecular Diversity - Vascular endothelial growth factor receptor-2 (VEGFR-2) is critically involved in cancer angiogenesis. Blocking of VEGFR-2 signaling pathway proved effective suppression of... 相似文献
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Amany Belal Mohamed A. Elanany Eman Y. Santali Ahmed A. Al-Karmalawy Moustafa O. Aboelez Ali H. Amin Magda H. Abdellattif Ahmed B. M. Mehany Hazem Elkady 《Molecules (Basel, Switzerland)》2022,27(11)
Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening using docking studies against both the MMP-2 and MMP-9 proteins to find the most promising inhibitors as a proposed computational mechanism to treat keratoconus. Matrix metalloproteinases (MMPs) are zinc-dependent proteases, and MMP inhibitors (MMPIs) are usually designed to interact with zinc ion in the catalytic (CAT) domain, thus interfering with enzymatic activity. In our research work, the FDA-approved ophthalmic medications will be investigated as MMPIs, to explore if they can be repurposed for KC treatment. The obtained findings of the docking study suggest that atenolol and ampicillin are able to accommodate into the active sites of MMP-2 and MMP-9. Additionally, both exhibited binding modes similar to inhibitors used as references, with an ability to bind to the zinc of the CAT. Molecular dynamic simulations and the MM-GBSA binding free-energy calculations revealed their stable binding over the course of 50 ns. An additional pharmacophoric study was carried out on MMP-9 (PDB ID: 1GKC) using the co-crystallized ligand as a reference for the future design and screening of the MMP-9 inhibitors. These promising results open the door to further biological research to confirm such theoretical results. 相似文献
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Kaisar Khan Khaled Mnaymneh Hazem Awad Imad Hasan Trevor Hall 《Applied Physics A: Materials Science & Processing》2014,117(2):629-634
Metamaterials that provide negative refraction can be implemented in photonic crystals (PhCs) through careful design of the devices. Theoretically, we demonstrate that the dispersion can be altered to achieve negative refraction. This can be done through engineering the geometry of the device as well as selecting appropriate materials. The PhC also demonstrates slow light that facilitate sensing chemicals or biological agents. Using metallic materials such as gold nano-particle enables PhCs to guide optical waves in desired pathways. Also using magnetic materials such as highly doped n-GaAs, we can tune the band gap by changing magnetic field. The simulated results are consistent with some of the previously reported experimental results and give us guidance for future experiments. 相似文献
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The influence of temperature dependent viscosity and thermal conductivity on the transient Couette flow with heat transfer is studied. An external uniform magnetic field is applied perpendicular to the parallel plates and the Hall effect is taken into consideration. The fluid is acted upon by a constant pressure gradient. The two plates are kept at two constant but different temperatures and the viscous and Joule dissipations are considered in the energy equation. A numerical solution for the governing non-linear equations of motion and the energy equation is obtained. The effect of the Hall term and the temperature dependent viscosity and thermal conductivity on both the velocity and temperature distributions is examined. 相似文献
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O. Shaya B. Khamaisi Y. Usherenko A. Doron Y. Rosenwaks 《Applied Surface Science》2010,256(19):5789-4392
In order to understand the biosensing mechanism of field-effect based biosensors and optimize their performance, the effect of each of its molecular building block must be understood. In this work the gating effect of self-assembled linker molecules on field-effect transistor was studied in detail. We have combined Kelvin probe force microscopy, current-voltage measurements, capacitance-voltage measurements, equivalent circuit modeling and device simulations in order to trace the mechanism of silicon-on-insulator biological field-effect transistors. The measurements were conducted on the widely used linker molecules (3-aminopropyl)-trimethoxysilane (APTMS) and 11-aminoundecyl-triethoxysilane (AUTES), which were self-assembled on ozone activated silicon oxide surface covering the transistor channel. In a dry environment, the work function of the modified silicon oxide decreased by more than 1.5 eV, and the transistor threshold voltage increased by about 30 V following the self-assembly. A detailed analysis indicates that these changes are due to negative induced charges on the top dielectric layer, and an effective dipole due to the polar monolayer. However, the self-assembly did not change the silicon flat-band voltage when in contact with an electrolyte. This is attributed to electrostatic screening by the electrolyte. 相似文献
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A “Schizophotonic” All‐In‐One Nanoparticle Coating for Multiplexed SE(R)RS Biomedical Imaging
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Dr. Pasquale Iacono Dr. Hazem Karabeber Prof. Dr. Moritz F. Kircher 《Angewandte Chemie (International ed. in English)》2014,53(44):11756-11761
SERS nanoprobes for in vivo biomedical applications require high quantum yield, long circulation times, and maximum colloidal stability. Traditional synthetic routes require high metal–dye affinities and are challenged by unfavorable electrostatic interactions and limited scalability. We report the synthesis of a new near‐IR active poly(N‐(2‐hydroxypropyl) methacrylamide) (pHPMA). The integration of various SERS reporters into a biocompatible polymeric surface coating allows for controlled dye incorporation, high colloidal stability, and optimized in vivo circulation times. This technique allows the synthesis of very small (<20 nm) SERS probes, which is crucial for the design of excretable and thus highly translatable imaging agents. Depending on their size, the “schizophotonic” nanoparticles can emit both SERS and fluorescence. We demonstrate the capability of this all‐in‐one gold surface coating and SERS reporter for multiplexed lymph‐node imaging. 相似文献