Discovery and evaluation of inhibitory activity and mechanism of arylcoumarin derivatives on Theileria annulata enolase by in vitro and molecular docking studies

Molecular Diversity - In this study, the inhibition potential of 3- and 4-arylcoumarin derivatives on Theileria annulata enolase (TaENO) was assessed for the first time in the literature. Firstly,...     

Crystal Structures of 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione and 2-Chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione

Crystallography Reports - 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione (1) and 2-chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione (2) were obtained according...     

Synthesis,antimicrobial and thermal studies of nitropyridine-substituted double armed benzo-15-crown-5 ligands; alkali (Na+ and K+) and transition metal (Ag+) complexes; reduction of nitro compounds

Journal of Inclusion Phenomena and Macrocyclic Chemistry - Nitropyridine substituted double-armed benzo 15-crown-5 compounds (1–4) were synthesized by the reactions of...     

Effect of the crystal structure on the X-ray intensity ratios of 3d metals

The linear muffin-tin-orbital method is used to calculate the d electron populations of 3d metals in different crystal structures. It is found that valence electronic structure and hence the Kβ/Kα X-ray intensity ratio (R) of a 3d metal changes with the crystal structure. It is concluded that R of a 3d metal depends on the energy band structure rather than the chemical environment.     

Dual-frequency division de-multiplexer based on cascaded photonic crystal waveguides

A dual-frequency division de-multiplexing mechanism is demonstrated using cascaded photonic crystal waveguides with unequal waveguide widths. The de-multiplexing mechanism is based on the frequency shift of the waveguide bands for the unequal widths of the photonic crystal waveguides. The modulation in the waveguide bands is used for providing frequency selectivity to the system. The slow light regime of the waveguide bands is utilized for extracting the desired frequency bands from a wider photonic crystal waveguide that has a relatively larger group velocity than the main waveguide for the de-multiplexed frequencies. In other words, the wider spatial distribution of the electric fields in the transverse direction of the waveguide for slow light modes is utilized in order to achieve the dropping of the modes to the output channels. The spectral and spatial de-multiplexing features are numerically verified. It can be stated that the presented mechanism can be used to de-multiplex more than two frequency intervals by cascading new photonic crystal waveguides with properly selected widths.     

Block‐brush copolymers via ROMP and sequential double click reaction strategy

We report an efficient way, sequential double click reactions, for the preparation of brush copolymers with AB block‐brush architectures containing polyoxanorbornene (poly (ONB)) backbone and poly(ε‐caprolactone) (PCL), poly(methyl methacrylate) (PMMA) or poly(tert‐butyl acrylate) (PtBA) side chains: poly(ONB‐g‐PMMA)‐b‐poly(ONB‐g‐PCL) and poly(ONB‐g‐PtBA)‐b‐poly(ONB‐g‐PCL). The living ROMP of ONB affords the synthesis of well‐defined poly(ONB‐anthracene)₂₀‐b‐poly (ONB‐azide)₅ block copolymer with anthryl and azide pendant groups. Subsequently, well‐defined linear alkyne end‐functionalized PCL (PCL‐alkyne), maleimide end‐functionalized PMMA (PMMA‐MI) and PtBA‐MI were introduced onto the block copolymer via sequential azide‐alkyne and Diels‐Alder click reactions, thus yielding block‐brush copolymers. The molecular weight of block‐brush copolymers was measured via triple detection GPC (TD‐GPC) introducing the experimentally calculated dn/dc values to the software. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011     

Investigation of acetone,butanol and carbon dioxide as new breath biomarkers for convenient and noninvasive diagnosis of obstructive sleep apnea syndrome

The objective of the present study was to investigate whether analysis of carbon dioxide, acetone and/or butanol present in human breath can be used as a simple and noninvasive diagnosis method for obstructive sleep apnea syndrome (OSAS). For this purpose, overnight changes in the concentrations of these breath molecules were measured before and after sleep in 10 patients who underwent polysomnography and were diagnosed with OSAS, and were compared with the levels of these biomarkers determined after sleep in 10 healthy subjects. The concentrations of exhaled carbon dioxide were measured using external cavity laser‐based off‐axis cavity enhanced absorption spectroscopy, whereas the levels of exhaled acetone and butanol were determined using thermal desorption gas chromatography mass spectrometry. We observed no significant changes in the levels of exhaled acetone and carbon dioxide in OSAS patients after sleep compared with pre‐sleep values and compared with those in healthy control subjects. However, for the first time, to our knowledge, analyses of expired air showed an increased concentration of butanol after sleep compared with that before sleep and compared with that in healthy subjects. These results suggest that butanol can be established as a potential biomarker to enable the convenient and noninvasive diagnosis of OSAS in the future.     

Synthesis of asymmetrical tridendate Schiff bases and metal complexes and investigation of anticarcinogen effects on human colon and cervical cancers

The metal complexes of Zn(II), Ni(II), Cu(II) and Pb(II) with asymmetrical Schiff bases were synthesized. The asymmetrical Schiff base was obtained through the condensation of 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde and biphenyl-4-carbaldehyde. The new Schiff base ligands (L₁' and L₂') and their metal complexes were characterized by TG/DTG, FT-IR, ¹H-NMR, UV–Vis, ESR, powder XRD, elemental analysis, magnetic moment and fluorescence studies. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, while Ni(II) and Zn(II) complexes are crystalline. The anticarcinogenic effects of L₁' and L₂' were also investigated against colon (SW-620) and cervical cancer (HeLa) cell lines and compound L₂' was found to possess the highest anticarcinogenic potential, with 16.7 µM and 27.5 µM of IC₅₀ values for HeLa and SW620 cells, respectively.     

Solar Reforming of Biomass with Homogeneous Carbon Dots

A sunlight‐powered process is reported that employs carbon dots (CDs) as light absorbers for the conversion of lignocellulose into sustainable H₂ fuel and organics. This photocatalytic system operates in pure and untreated sea water at benign pH (2–8) and ambient temperature and pressure. The CDs can be produced in a scalable synthesis directly from biomass itself and their solubility allows for good interactions with the insoluble biomass substrates. They also display excellent photophysical properties with a high fraction of long‐lived charge carriers and the availability of a reductive and an oxidative quenching pathway. The presented CD‐based biomass photoconversion system opens new avenues for sustainable, practical, and renewable fuel production through biomass valorization.