全文获取类型
收费全文 | 496篇 |
免费 | 27篇 |
国内免费 | 1篇 |
专业分类
化学 | 417篇 |
晶体学 | 3篇 |
力学 | 2篇 |
数学 | 5篇 |
物理学 | 97篇 |
出版年
2021年 | 5篇 |
2020年 | 7篇 |
2019年 | 10篇 |
2017年 | 4篇 |
2016年 | 7篇 |
2015年 | 17篇 |
2014年 | 15篇 |
2013年 | 20篇 |
2012年 | 36篇 |
2011年 | 23篇 |
2010年 | 17篇 |
2009年 | 16篇 |
2008年 | 20篇 |
2007年 | 17篇 |
2006年 | 17篇 |
2005年 | 15篇 |
2004年 | 16篇 |
2003年 | 18篇 |
2002年 | 12篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 6篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 20篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1972年 | 8篇 |
1968年 | 5篇 |
1967年 | 3篇 |
排序方式: 共有524条查询结果,搜索用时 15 毫秒
521.
The mechanism of a gentamicin-induced decrease in apical membrane enzyme activities was investigated in LLC-PK1 cells. Increasing activities of apical membrane enzymes (alkaline phosphatase, aminopeptidase, and gamma-glutamyltransferase) were markedly suppressed by gentamicin during growth in culture. On the other hand, a lesser effect was observed when the activities of these enzymes were decreasing or relatively constant. Gentamicin treatment decreased the maximal enzyme activities of alkaline phosphatase and aminopeptidase, indicating that the number of active enzyme molecules in the apical membrane was decreased by gentamicin. [3H]Leucine incorporation in LLC-PK1 cells was inhibited by gentamicin in a dose-dependent manner, followed by a reduction of total protein. In addition, a well-known protein synthesis inhibitor, cycloheximide, also decreased the apical enzyme activities. These results suggest that the inhibition of protein synthesis by gentamicin is a possible cause of the decreased activities of apical membrane enzymes in LLC-PK1 cells. The inhibition of protein synthesis may be related to the nephrotoxicity induced by aminoglycoside antibiotics. 相似文献
522.
523.
Jun Okuda Thomas Kleinhenn Peter Knig Insa Taden Silvana Ngo Ilya L. Rushkin 《Macromolecular Symposia》1995,95(1):195-202
Mono(cyclopentadienyl)titanium complexes of the general formula Ti(η5-C5R5)X2OR' were designed as structurally well-defined mononuclear initiators for the ring-opening polymerization of four-, six-, and seven-membered lactones. Living pseudo-anionic mechanism with acyl-oxygen cleavage is suggested by various NMR spectroscopic studies as well as the isolation of the mono(insertion) products. The nature of the ancillary ligands lead to significant changes in the polymerization activity and is discussed in terms of electronic and steric effects. 相似文献