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Prasant Kumar Jena Disha Trivedi Harshita Chaudhary Tapasa Kumar Sahoo Sriram Seshadri 《Applied biochemistry and biotechnology》2013,169(7):2088-2100
The increase of multidrug-resistant pathogens and the restriction on the use antibiotics due to its side effects have drawn attention to the search for possible alternatives. Bacteriocins are small antimicrobial peptides produced by numerous bacteria. Much interest has been focused on bacteriocins because they exhibit inhibitory activity against pathogens. Lactic acid bacteria possess the ability to synthesize antimicrobial compounds (like bacteriocin) during their growth. In this study, an antibacterial substance (bacteriocin PJ4) produced by Lactobacillus helveticus PJ4, isolated from rat gut microflora, was identified as bacteriocin. It was effective against wide assay of both Gram-positive and Gram-negative bacteria involved in various diseases, including Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus. The antimicrobial peptide was relatively heat-resistant and also active over a wide pH range of 2–10. It has been partially purified to homogeneity using ammonium sulfate precipitation and size exclusion chromatography and checked on reverse-phase high-performance liquid chromatography. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis of bacteriocin PJ4 purified through size exclusion chromatography resolved ~6.5 kDa protein with bacteriocin activity. The peptide is inactivated by proteolytic enzymes, trypsin, and lipase but not when treated with catalase, α-amylase, and pepsin. It showed a bactericidal mode of action against the indicator strains E. coli MTCC443, Lactobacillus casei MTCC1423, and E. faecalis DT48. Such characteristics indicate that this bacteriocin may be a potential candidate for alternative agents to control important pathogens. 相似文献
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Phougat Neelam Vasudevan Padma Jha Narendra Kumar Bandhopadhyay Deb Kumar 《Transition Metal Chemistry》2003,28(7):838-847
Transition Metal Chemistry - 相似文献
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Dr. Harshita Kumari Dr. Ping Jin Dr. Simon J. Teat Dr. Charles L. Barnes Dr. Scott J. Dalgarno Prof. Jerry L. Atwood 《Angewandte Chemie (International ed. in English)》2014,53(48):13088-13092
Anions play a crucial role in locking alkali metals on the interior of metal–organic capsules that contain structural water gates. This role is further evidenced when stitching‐up the capsule seam, resulting in either expulsion or trapping of cesium ions depending on the anion employed. 相似文献
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H Kumari SR Kline CL Dennis AV Mossine RL Paul CA Deakyne JL Atwood 《Angewandte Chemie (International ed. in English)》2012,51(37):9263-9266
Metal-containing tubes: The structures of several iron-containing C-methylpyrogallol[4]arene (PgC(1) ) nanoassemblies were studied in both the solid and solution phases. The nanoassemblies have a tubular architecture with the iron as part of the framework (see picture; gray C, red O, turquoise/blue Fe), and magnetic analysis suggests a canted or spiral arrangement of the iron centers. 相似文献
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