全文获取类型
收费全文 | 2053篇 |
免费 | 39篇 |
国内免费 | 14篇 |
专业分类
化学 | 1152篇 |
晶体学 | 8篇 |
力学 | 81篇 |
综合类 | 1篇 |
数学 | 211篇 |
物理学 | 653篇 |
出版年
2022年 | 13篇 |
2021年 | 15篇 |
2020年 | 19篇 |
2019年 | 23篇 |
2018年 | 13篇 |
2017年 | 15篇 |
2016年 | 20篇 |
2014年 | 25篇 |
2013年 | 83篇 |
2012年 | 70篇 |
2011年 | 92篇 |
2010年 | 47篇 |
2009年 | 27篇 |
2008年 | 71篇 |
2007年 | 80篇 |
2006年 | 94篇 |
2005年 | 82篇 |
2004年 | 73篇 |
2003年 | 74篇 |
2002年 | 58篇 |
2001年 | 62篇 |
2000年 | 59篇 |
1999年 | 36篇 |
1998年 | 33篇 |
1997年 | 35篇 |
1996年 | 37篇 |
1995年 | 41篇 |
1994年 | 46篇 |
1993年 | 59篇 |
1992年 | 35篇 |
1991年 | 35篇 |
1990年 | 37篇 |
1989年 | 35篇 |
1988年 | 23篇 |
1987年 | 31篇 |
1986年 | 19篇 |
1985年 | 35篇 |
1984年 | 23篇 |
1983年 | 32篇 |
1982年 | 24篇 |
1981年 | 24篇 |
1980年 | 27篇 |
1979年 | 19篇 |
1978年 | 24篇 |
1977年 | 35篇 |
1975年 | 30篇 |
1974年 | 23篇 |
1973年 | 18篇 |
1972年 | 24篇 |
1966年 | 12篇 |
排序方式: 共有2106条查询结果,搜索用时 15 毫秒
101.
102.
Harris GJ Polyansky OL Tennyson J 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2002,58(4):673-690
We have calculated an ab initio HCN/HNC linelist for all transitions up to J= 25 and 18000 cm(-1) above the zero point energy. This linelist contains more than 200 million lines each with frequencies and transition dipoles. The linelist has been calculated using our semi-global HCN/HNC VQZANO + PES and dipole moment surface, which were reported in van Mourik et al. (J. Chem. Phys. 115 (2001) 3706). With this linelist we synthesise absorption spectra of HCN and HNC at 298 K and we present the band centre and band transition dipoles for the bands which are major features in these spectra. Several of the HCN bands and many of the HNC bands have not been previously studied. Our line intensities reproduce via fully ab initio methods the unusual intensity structure of the HCN CN stretch fundamental (00(0)1) for the first time and also the forbidden (02(2)0) HCN bending overtone. We also compare the J = 1-->0 pure rotational transition dipole in the HCN/HNC ground and vibrationally excited states with experimental and existing ab initio results. 相似文献
103.
George Amato Vineetha Vasukuttan Danni Harris Lucas Laudermilk Jennifer Lucitti Scott Runyon Rangan Maitra 《Molecules (Basel, Switzerland)》2022,27(17)
Selective modulation of peripheral cannabinoid receptors (CBRs) has potential therapeutic applications in medical conditions, including obesity, diabetes, liver diseases, GI disorders and pain. While there have been considerable efforts to produce selective antagonists or full agonists of CBRs, there has been limited reports on the development of partial agonists. Partial agonists targeting peripheral CBRs may have desirable pharmacological profiles while not producing centrally mediated dissociative effects. Bayer reported that BAY 59-3074 is a CNS penetrant partial agonist of both CB1 and CB2 receptors with efficacy in rat models of neuropathic and inflammatory pain. In this report, we demonstrate our efforts to synthesize analogs that would favor peripheral selectivity, while maintaining partial agonism of CB1. Our efforts led to the identification of a novel compound, which is a partial agonist of the human CB1 (hCB1) receptor with vastly diminished brain exposure compared to BAY 59-3074. 相似文献
104.
Kuo-yuan Hung Renata Kowalczyk Ami Desai Margaret A. Brimble John F. Marshall Paul W. R. Harris 《Molecules (Basel, Switzerland)》2022,27(14)
A20FMDV2 is a 20-mer peptide that exhibits high selectivity and affinity for the tumour-related αvβ6 integrin that can compete with extracellular ligands for the crucial RGD binding site, playing a role as a promising αvβ6-specific inhibitor for anti-cancer therapies. Unfortunately, the clinical value of A20FMDV2 is limited by its poor half-life in blood caused by rapid renal excretion and its reported high susceptibility to serum proteases. The incorporation of poly (ethylene glycol) chains, coined PEGylation, is a well-established approach to improve the pharmacokinetic properties of drug molecules. Here, we report a systematic study on the incorporation of a varying number of ethylene glycol units (1–20) into the A20FMDV2 peptide to establish the effects of PEGylation size on the peptide stability in both rat serum and human plasma. In addition, the effect of acetyl and propionyl PEGylation handles on peptide stability is also described. Selected peptide analogues were assessed for integrin-αvβ6-targeted binding, showing good specificity and activity in vitro. Stability studies in rat serum established that all of the PEGylated peptides displayed good stability, and an A20FMDV2 peptide containing twenty ethylene glycol units (PEG20) was the most stable. Surprisingly, the stability testing in human plasma identified shorter PEGs (PEG2 and PEG5) as more resistant to degradation than longer PEGs, a trend which was also observed with affinity binding to integrin αvβ6. 相似文献
105.
Mary Marshall Zhaoguo Zhu Rachel Harris Prof. Dr. Kit H. Bowen Wei Wang Jie Wang Chu Gong Prof. Dr. Xinxing Zhang 《Chemphyschem》2021,22(1):5-8
Thorium and its compounds have been widely investigated as important nuclear materials. Previous research focused on the potential use of thorium hydrides, such as ThH2, ThH4, and Th4H15, as nuclear fuels. Here, we report studies of the anion, ThH5−, by anion photoelectron spectroscopy and computations. The resulting experimental and theoretical vertical detachment energies (VDE) for ThH5− are 4.09 eV and 4.11 eV, respectively. These values and the agreement between theory and experiment facilitated the characterization of the structure of the ThH5− anion and showed its neutral counterpart, ThH5 to be a superhalogen. ThH5−, which exhibits a C4v structure with five Th−H single bonds, possesses the largest known H/M ratio among the actinide elements, M. The adaptive natural density partitioning (AdNDP) method was used to further analyze the chemical bonding of ThH5− and to confirm the existence of five Th−H single bonds in the ThH5− molecular anion. 相似文献
106.
N. N. Otwagin F. Moll W. E. Cohen E. E. Harris H. Fielder A. S. Gnedowski A. I. Ssolnze A. Petersen H. A. Czernotzky J. I. Vogelsohn N. W. Kalmykova M. M. Eiderman M. A. Weitzman M. Ilmenew H. K. Griffin H. H. Storch E. R. Bolton K. A. Williams M. Tonegutti E. Brandimarte E. Sauerbrei W. Scheruhn A. Goetz U. W. O. Gould Baxelite Corporation 《Analytical and bioanalytical chemistry》1939,117(5-6):235-240
107.
108.
109.
110.
Dibenzyl sulphones can be prepared from the corresponding benzyl halide under mild, economic and efficient conditions, using either sodium dithionite / Aliquat, or sodium formaldehyde sulphoxylate /potassium carbonate in the absence of solvent. 相似文献