Phase-averaged measurements of the turbulence properties in the near wake of a circular cylinder at high Reynolds number by 2C-PIV and 3C-PIV

The near wake of a circular cylinder at high Reynolds number is investigated by means of 2D-PIV and stereoscopic PIV. Phase-averaged measurements of the instantaneous fields have been performed. The linear stochastic estimation (LSE) has been adapted to estimate the phase-averaged quantities. This avoids the long time acquisition and the large storage needed for phase averaging. A good comparison is achieved between the results of the conditional sampling and those of LSE. Therefore, the estimation has been applied to the three-component datas and allowed evaluation of the whole phase-averaged turbulent stress tensor.     

Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions

Small peptides containing combinations of cysteine, tyrosine, histidine, and serine residues react with octafluorocyclopentene (OFCP) to afford atypically structured macrocycles through successive vinylic substitutions. The reactions proceed rapidly in air at 0 °C and are tolerant of spectating tryptophan, asparagine, glutamine, and threonine residues. Hexapeptides of consensus sequence YXCXXC displace four fluorine atoms from OFCP to generate fluorinated macrobicyclic compounds that display dual‐turn surfaces. The method provides facile access to a wide range of previously unknown heterocyclic structures.     

Large ring-forming alkylations provide facile access to composite macrocycles

Macrocyclic compounds have potential to enable drug discovery for protein targets with extended, solvent-exposed binding sites. Crystallographic structures of peptides bound at such sites show strong surface complementarity and frequent aromatic side-chain contacts. In an effort to capture these features in stabilized small molecules, we describe a method to convert linear peptides into constrained macrocycles based upon their aromatic content. Designed templates initiate the venerable Friedel–Crafts alkylation to form large rings efficiently at room temperature – routinely within minutes – and unimpeded by polar functional groups. No protecting groups, metals, or air-free techniques are required. Regiochemistry can be tuned electronically to explore diverse macrocycle connectivities. Templates with additional reaction capabilities can further manipulate macrocycle structure. The chemistry lays a foundation to extend studies of how the size, shape and constitution of peptidyl macrocycles correlate with their pharmacological properties.     

Solute-solvent interactions in imidazolium camphorsulfonate ionic liquids

We directly observe the interaction between 1-butyl-3-methylimidazolium (bmim) or 1-butyl-2,3-dimethylimidazolium (bm(2)im) and the solute, ethyl acrylate (EA), which is the popular dienophile in the Diels-Alder reaction and an H-bonding acceptor, by using specially designed electrospray mass spectrometry. In imidazolium ionic liquids, cation-anion interactions are controlled by selecting the appropriate anion, and the naked C(2)-H of imidazolium, which loosely interacts with its counterion, can readily interact with an H-bonding acceptable solute. The ion-counterion (solvent-solvent) interaction affects the ion-solute (solvent-solute) interaction. This relation is one of the key criteria for selecting the cation-anion combination in tailoring ILs.     

Turbulence modelling of the flow past a pitching NACA0012 airfoil at and Reynolds numbers

This paper provides a study of the NACA0012 dynamic stall at Reynolds numbers 10⁵ and 10⁶ by means of two- and three-dimensional numerical simulations. The turbulence effect on the dynamic stall is studied by statistical modelling. The results are compared with experiments concerning each test case. Standard URANS turbulence modelling have shown a quite dissipative character that attenuates the instabilities and the vortex structures related to the dynamic stall. The URANS approach Organised Eddy Simulation (OES) has shown an improved behaviour at the high Reynolds number range. Emphasis is given to the physical analysis of the three-dimensional dynamic stall structure, for which there exist few numerical results in the literature, as far as the Reynolds number range is concerned. This study has shown that the downstroke phases of the pitching motion are subjected to strong three-dimensional turbulence effects along the span, whereas the flow is practically two-dimensional during the upstroke motion.     

Mise en evidence des phenomenes de gelification dans les systemes dgeba et TGMDA-DDS par chromatography gazeuse inverse et methodes rheologique et de viscosimetrie

We have used three physicochemical methods, reverse phase gas chromatography, Calvet microcalorimetry and rheology to examine the kinetics of isothermal cross-linking in the polycondensation of epoxy-prepolymers with aromatic amines. Gas chromatography results further define those obtained with gel time meter and rheological methods, and furnish not only a “gel point” but also a “gelling zone” for the two systems investigated.     

Near-Wake Turbulence Properties around a Circular Cylinder at High Reynolds Number

The present study investigates the turbulent properties of the flow around a circular cylinder in the near-wake and in the near-wall upstream region at the Reynolds number 140,000. A detailed cartography of the mean and turbulent velocity fields using a moderate blockage and aspect ratio is provided in order to use the present results for direct comparisons with realisable 3D Navier-Stokes computations. The flow structure is analysed by means of two experiments using respectively the LDV and the PIV techniques, both providing a refined grid of measurement points. The dynamics of the separation region, the growth and decay of turbulence in the near wake, as well as the spatial growth of the organised mode are analysed.