Evaluation of Virucidal Efficacy of Cold Plasma on Bacteriophage Inside a Three-Layered Sterilization Chamber

Plasma Chemistry and Plasma Processing - Traditional disinfection methods against pathogens have numerous shortcomings, and inventive methods like cold plasma are required for virus inactivation....     

Different approaches in thin-layer chromatography for enantioresolution of acebutolol using colistin sulfate as chiral selector

JPC – Journal of Planar Chromatography – Modern TLC - This work reports the enantioresolution of (RS)-acebutolol (ACB) by a thin-layer chromatographic method involving colistin sulfate...     

Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors

Molecular Diversity - Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the...     

On quadruple integral equations related to a certain crack problem

An exact solution of a four part mixed boundary value problem representing a three colinear crack system connected with specified crack opening displacements between the cracks is obtained. The three cracks thus become one with pressure and/or opening displacement prescribed on the crack face. From considerations of dual symmetry and a formulation based on Papkovich-Neuber harmonic functions, the boundary value problem is reduced to solving a quadruple set of integral equations. An exact solution of these equations is derived using a modified finite Hilbert transform technique. The closed form results for the stress distributions and the crack-tip stress intensity factors are presented. Limiting cases of the solution yield results which agree with well known solutions.     

New sol–gel precursors for binary oxides of antimony,Sb<Subscript>2</Subscript>O<Subscript>3</Subscript> (senarmonite) and α-Sb<Subscript>2</Subscript>O<Subscript>4</Subscript>: synthesis and characterization of some ketoximate modified antimony(III) alkoxides

Hydrolysis of pure Sb(OPrⁱ)₃ by sol–gel method followed by sintering at 500 °C yields microcrystallites of Sb₂O₃ (senarmonite phase). Under similar conditions bimetallic alkoxide, [NaSb(OPrⁱ)₄], yields a mixture of binary oxides Sb₂O₃ and Sb₂O₄. Chemical modification of Sb(OPrⁱ)₃ with oximes forms monomeric products of the type [Sb(OPrⁱ)_3−n {ON=C(CH₃)R} _n ] {where R = CH₃, n = 1 [1]; n = 2 [2]; n = 3 [3]; R = 2-C₅H₄N, n = 1 [4]; n = 2 [5]; n = 3 [6]; R = 2-C₄H₃O, n = 1 [7]; n = 2 [8]; n = 3 [9]; R = 2-C₄H₃S, n = 1 [10]; n = 2 [11]; n = 3 [12]}. The liquid products [1–3, 7 & 10] were purified by distillation while the solids by recrystallization. All these products were characterized by elemental analyses, IR, NMR (¹H and ¹³C{¹H}) and representative derivatives [1], [2] and [3] by FAB mass studies. On the basis of these studies, a distorted pyramidal structure for all the derivatives may be assumed in the solution state containing an end-on coordination of oximes with the metal atom. Hydrolysis of the distilled precursors [1], [2] and [3] under sol–gel conditions yields pure nano-sized α-Sb₂O₄. All the oxides were characterized by XRD, SEM and EDX analysis exhibiting minimum particle size for the oxide obtained from the precursor [3].     

Eggshell Nanosheets: Synthesis,Properties, and Their Forensic Applications in Latent Friction Ridges Development

Since waste materials are used to identify, individualize, and evaluate evidence like fingerprints, palmprints, footprints, etc. that are found at a crime scene, they have a substantial impact on the field of forensic science. Many waste powders have recently been employed in fingerprint recognition. Nanosheets made up of eggshells have been put forward as an application in friction ridge development. Eggshell is a biochemical substance made up of chemical compounds like calcium carbonate, which is considered as a waste product. For the formation of an eggshell nanosheet (ESN), shells are dried and crushed into a fine powder and to get this powder in the form of a nanosheet, the Ball milling technique is used. The synthesis of pure ESN is confirmed by Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD) techniques. The size of nanosheets ranged from 30 to 90 nm as shown in SEM images. Developed powder is then used for the application of fingerprint development and it provides excellent results on all porous, non-porous, and semi-porous surfaces. Thus, this newly synthesized ESN powder can be used as a significant powder method in latent fingerprint technology.     

Spectrophotometric Estimation of Citral in Essential Oil

Citral forms an important constituent of many essential oils. It is present in a large number of essential oils containing lemon perfume and is of great commercial value. Methods of estimation of citral, available in literature are not very accurate or time consuming. The method developed by the author is based on colour change reaction of citral with rhodium (III). If all necessary requirements for experiment are ready, the estimation of citral occures within ten minutes. Rhodium (III) can also be determined with its colour change reaction by citral.     

Indirect enantioseparation of proteinogenic amino acids using naproxen‐based chiral derivatizing reagent and HPLC

Diastereomers of 18 proteinogenic amino acids were synthesized under microwave irradiation and by vortexing using (S)‐naproxen–benzotriazole as chiral derivatizing reagent. The diastereomers synthesized by two approaches were found to be identical in terms of their characterization and chromatographic data. A linear gradient of triethylammonium phosphate (pH 3.5)–acetonitrile (30–65%, within 35 min) was found to be successful using reversed‐phase high‐performance liquid chromatography for their separation. Detection was carried out at 231 nm and sharp peaks were obtained. The method was validated for accuracy, precision and limit of detection. Copyright © 2012 John Wiley & Sons, Ltd.     

Pharmacokinetic application of a bio‐analytical LC‐MS method developed for 5‐fluorouracil and methotrexate in mouse plasma,brain and urine

In the past we have reported significant cognitive deficits in mice receiving 5‐fluorouracil in combination with low‐dose methotrexate. To explain such interactions, a pharmacokinetic study was designed. A sensitive bio‐analytical method was therefore developed and validated for 5‐fluorouracil and methotrexate in mouse plasma, brain and urine with liquid chromatography coupled to a single quadrupole mass spectrometer. Chromatographic separation was accomplished by Agilent® Zorbax® SB‐C₁₈ column, with isocratic elution (5 mM ammonium acetate and methanol, 70:30, %v/v) at a flow rate of 300 μL/min. The limit of quantitation for both drugs was 15.6 ng/mL (plasma and brain) and 78.1 ng/mL (urine), with interday and intraday precision and accuracy ≤15% and a total run time of 6 min. This bio‐analytical method was used for the pharmacokinetic characterization of 5‐fluorouracil and methotrexate in mouse plasma, brain and urine over a period of 24 h. This method allowed characterization of the brain concentrations of 5‐fluorouracil over a period of 24 h. Copyright © 2013 John Wiley & Sons, Ltd.