全文获取类型
收费全文 | 1697篇 |
免费 | 67篇 |
国内免费 | 14篇 |
专业分类
化学 | 1138篇 |
晶体学 | 80篇 |
力学 | 24篇 |
数学 | 165篇 |
物理学 | 371篇 |
出版年
2023年 | 18篇 |
2022年 | 34篇 |
2021年 | 27篇 |
2020年 | 31篇 |
2019年 | 50篇 |
2018年 | 50篇 |
2017年 | 41篇 |
2016年 | 58篇 |
2015年 | 59篇 |
2014年 | 75篇 |
2013年 | 129篇 |
2012年 | 95篇 |
2011年 | 131篇 |
2010年 | 71篇 |
2009年 | 61篇 |
2008年 | 104篇 |
2007年 | 73篇 |
2006年 | 69篇 |
2005年 | 45篇 |
2004年 | 39篇 |
2003年 | 39篇 |
2002年 | 46篇 |
2001年 | 23篇 |
2000年 | 24篇 |
1999年 | 19篇 |
1998年 | 10篇 |
1997年 | 10篇 |
1996年 | 17篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 19篇 |
1992年 | 20篇 |
1991年 | 20篇 |
1990年 | 18篇 |
1989年 | 10篇 |
1988年 | 10篇 |
1987年 | 10篇 |
1986年 | 13篇 |
1985年 | 16篇 |
1984年 | 27篇 |
1983年 | 24篇 |
1982年 | 17篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 6篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1974年 | 9篇 |
排序方式: 共有1778条查询结果,搜索用时 15 毫秒
31.
T. Balakrishnan S. Hari Babu A. Perumal 《Journal of polymer science. Part A, Polymer chemistry》1990,28(6):1421-1434
The alkylation and cycloalkylation of phenylacetonitrile (PAN) with excess of 1-bromobutane and 1,4-dibromobutane respectively catalyzed by aqueous NaOH and insoluble polystyrene-bound benzyltriethylammonium chloride were studied and the rates depend upon several experimental parameters. The rate of cycloalkylation of PAN is five times faster than the alkylation and the former proceeds even in the absence of the solid catalyst. Both alkylation and cycloalkylation gave higher rates in reverse addition method than in direct addition. Deprotonation of PAN by hydroxide ion takes place without participation of the polymeric catalyst. The electrostatic force between the positive charge on the nitrogen atom of catalyst and carbanion is responsible for alkylation of active nitrile with polystyrene-bound phase-transfer catalyst. The rates of both the reactions increase with increased stirring speed, ring substitution, hydroxide ion concentration and catalyst amount and decrease with increased particle size and the degree of cross-linking of the polymer. Apparent activation energies for the reactions were calculated. The kinetic results are discussed in terms of mass transfer and a combination of intraparticle diffusion and intrinsic reactivity limitations of the rates. 相似文献
32.
The reactions of an N-acyliminium ion pool with alkenes and alkynes gave gamma-amino alcohols and beta-amino carbonyl compounds, respectively, after treatment with H(2)O/Et(3)N. The present reaction serves as an efficient method for cationic carbohydroxylation of alkenes and alkynes. When vinyltrimethylsilane was used as an alkene, the reaction was highly diastereoselective and served as an access to an enantiomerically pure alpha-silyl-gamma-amino alcohol. [reaction: see text] 相似文献
33.
A series of novel monoazo disperse dyes derived from the coupling of diazotized 2-aminobenzo[b]thiophene derivatives with N-arylmaleimides is described. The monoazo disperse dyes applied to nylon fabric and their dyeing performance has been assessed. These dyes have been found to give light yellow to reddish pink color shades with very good depth and levelness on nylon fabric. The dyed fabric shows moderate light fastness and excellent washing, rubbing, perspiration, and sublimation fastness. The percentage dyebath exhaustion on nylon fabric has been found to be good and acceptable. 相似文献
34.
Pharmacokinetic studies of a novel trioxane antimalarial (99/411) in rats and monkeys using LC–MS/MS 下载免费PDF全文
The pharmacokinetic profile of 99/411, a novel anti‐malarial drug, was established in rats (12 mg/kg of body weight) and monkeys (20 mg/kg of body weight). Following oral administration, the presence of 99/411 was rapidly determined in rat plasma, tissues, urine, feces and monkey plasma using a validated LC–MS/MS method. The tissue distribution studies in rats indicated that the drug was partially distributed in all major tissues and plasma, and peak concentration levels were achieved within 0.5–4 h. Area under the curve in different rat tissues and plasma was found in order of blood > lung > intestine > heart > muscle > brain > kidney > spleen > liver. The total recoveries (within 86 h) of 99/411 were <0.0017% and <0.08% in urine and feces, respectively. The peak plasma concentration was 3499 ng/mL in rats after ~2 h of oral administration and 697–767 ng/mL in monkeys after ~6 h of oral administration. No plasma accumulation was observed in both male and female monkeys, even after multiple dosing. The preclinical pharmacokinetic profile and tissue distribution data are expected to assist in future clinical explorations of 99/411 as a promising anti‐malarial agent. 相似文献
35.
36.
Pyrazolopyrimidine and pyrimidopyrimidine derivatives have shown a wide range of biological activities such as acting as A1 adenosine receptors, kinase insert domain receptor (KDR), Rous sarcoma oncogene (Src), epidermal growth factor receptor (EGFR), antiproliferative, dihydrofolate reductase (DHFR), antimicrobial, antifungal, and lipid peroxidation. Because of this wide range of activities, we have synthesized pyrazolo[3,4‐d]pyrimidines and pyrimido[4,5‐d]pyrimidin‐4‐one derivatives. 相似文献
37.
Chul-Hee Lee M. Fatih Kilicaslan Babu Madavali Soon-Jik Hong 《Research on Chemical Intermediates》2014,40(7):2543-2551
In this study, n-type 95 %Bi2Te3-5 %Bi2Se3 thermoelectric materials have been produced by a combined process of gas atomization with subsequent magnetic pulsed compaction and spark plasma sintering, and then we investigated the behavior of transport properties with sintering temperature. The microstructural observation was performed by optical microscopy and scanning electron microscopy. The crystal structures were analyzed by X-ray diffractometer. The mechanical properties were calculated by measuring the density and micro-Vickers hardness of the samples. It was found that with increasing sintering temperature the gaps between powder particles decreases and the grain sizes were coarsened. The mechanical properties shows higher values along the parallel direction compared to the perpendicular direction to the pressing. The transport properties of the thermoelectric material were investigated with variation of the sintering temperatures. The maximum power factor 1.7 × 10?3 Wm?1 K?2 was measured at the sintering temperature of 450 °C. 相似文献
38.
Parag Deshpande Zhang Jie Ramesh Subbarayan Vijay Kumar Mamidi Raja Haranadha Babu Chunduri Tapas Das Sathyavageeswaran Shreeram 《Biomedical chromatography : BMC》2013,27(2):142-147
A simple, sensitive and specific high‐performance liquid chromatography mass spectrometry (LC‐MS/MS) method was developed and validated for the quantification of β‐hydroxy‐β‐methyl butyrate (HMB) in small volumes of rat plasma using warfarin as an internal standard (IS). The API‐4000 LC‐MS/MS was operated under the multiple reaction‐monitoring mode using the electrospray ionization technique. A simple liquid–liquid extraction process was used to extract HMB and IS from rat plasma. The total run time was 3 min and the elution of HMB and IS occurred at 1.48 and 1.75 min respectively; this was achieved with a mobile phase consisting of 0.1% formic acid in a water–acetonitrile mixture (15:85, v/v) at a flow rate of 1.0 mL/min on a Agilent Eclipse XDB C8 (150 × 4.6, 5 µm) column. The developed method was validated in rat plasma with a lower limit of quantitation of 30.0 ng/mL for HMB. A linear response function was established for the range of concentrations 30–4600 ng/mL (r > 0.998) for HMB. The intra‐ and inter‐day precision values for HMB were acceptable as per Food and Drug Administration guidelines. HMB was stable in the battery of stability studies, viz. bench‐top, autosampler freeze–thaw cycles and long‐term stability for 30 days in plasma. The developed assay method was applied to a bioavailability study in rats. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
39.
40.
Clay catalyzed Friedländer condensation of 2-amino arylaldehyde or ketone with carbonyl compounds containing α-methylene group has been achieved in solvent free condition under microwave irradiation to give polycyclic quinoline derivatives. 相似文献