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891.
Weizhu Bao Harald Garcke Robert Nürnberg Quan Zhao 《Numerical Methods for Partial Differential Equations》2023,39(1):759-794
We consider the evolution of curve networks in two dimensions (2d) and surface clusters in three dimensions (3d). The motion of the interfaces is described by surface diffusion, with boundary conditions at the triple junction points lines, where three interfaces meet, and at the boundary points lines, where an interface meets a fixed planar boundary. We propose a parametric finite element method based on a suitable variational formulation. The constructed method is semi-implicit and can be shown to satisfy the volume conservation of each enclosed bubble and the unconditional energy-stability, thus preserving the two fundamental geometric structures of the flow. Besides, the method has very good properties with respect to the distribution of mesh points, thus no mesh smoothing or regularization technique is required. A generalization of the introduced scheme to the case of anisotropic surface energies and non-neutral external boundaries is also considered. Numerical results are presented for the evolution of two-dimensional curve networks and three-dimensional surface clusters in the cases of both isotropic and anisotropic surface energies. 相似文献
892.
893.
Walter Schumann 《Experimental Mechanics》1973,13(6):225-231
In a general view, a comparison is made of different optical methods where either photoelastic models, opaque bodies with transparent coatings or noncontacted objects are examinèd with coherent light. Further, it is tried to show that some common features are contained by the three groups. These aspects concern the separation, by controlled determination, of displacement, rotation and strain (or of certain of their components), the multiplication of the optical effects in the detection and the elimination of secondary influences. In particular, the noncontacting method of wavefront reconstruction with double-exposure holograms is discussed and the role of the localization condition for the fringes in space is analyzed. On the other hand, it is illustrated that, besides the generally known birefringence and diffraction. use could be made of nonorthodox effects like rotation of the plane of polarization, second-harmonic generation in nonlinear optics, etc. This may, for instance, contribute to the optical instrumentation when transparent models and bodies with photoelastic coatings are investigated under the above aspects. 相似文献
894.
Harald Müller Michael Eggert Jürgen Czarske Lars Büttner Andreas Fischer 《Experiments in fluids》2007,43(2-3):223-232
The main advantage of the described Doppler global velocimeter (DGV) systems based on frequency modulation (FM) or frequency
shift keying (FSK) is that no reference detector is required. The frequency variation of the laser light during one modulation
period additionally allows an on-line calibration of the complete DGV system. Thus, the new method has the potential to reduce
the uncertainty of conventional DGV velocity measurements since time resolved velocity field measurements on a spinning disc
have shown standard deviations down to 0.02 m/s. On investigating flow fields, velocity components notably less than 0.5 m/s
were resolved. 相似文献
895.
Radical Compatibility with Nonaqueous Electrolytes and Its Impact on an All‐Organic Redox Flow Battery
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Dr. Xiaoliang Wei Dr. Wu Xu Dr. Jinhua Huang Dr. Lu Zhang Dr. Eric Walter Dr. Chad Lawrence Dr. M. Vijayakumar Dr. Wesley A. Henderson Dr. Tianbiao Liu Dr. Lelia Cosimbescu Dr. Bin Li Dr. Vincent Sprenkle Dr. Wei Wang 《Angewandte Chemie (International ed. in English)》2015,54(30):8684-8687
Nonaqueous redox flow batteries hold the promise of achieving higher energy density because of the broader voltage window than aqueous systems, but their current performance is limited by low redox material concentration, cell efficiency, cycling stability, and current density. We report a new nonaqueous all‐organic flow battery based on high concentrations of redox materials, which shows significant, comprehensive improvement in flow battery performance. A mechanistic electron spin resonance study reveals that the choice of supporting electrolytes greatly affects the chemical stability of the charged radical species especially the negative side radical anion, which dominates the cycling stability of these flow cells. This finding not only increases our fundamental understanding of performance degradation in flow batteries using radical‐based redox species, but also offers insights toward rational electrolyte optimization for improving the cycling stability of these flow batteries. 相似文献
896.
Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site‐Specific Conjugation
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Dr. Vanessa Siegmund Dr. Stefan Schmelz Stephan Dickgiesser Jan Beck Aileen Ebenig Heiko Fittler Dr. Holm Frauendorf Dr. Birgit Piater Dr. Ulrich A. K. Betz Dr. Olga Avrutina Dr. Andrea Scrima Prof. Dr. Hans‐Lothar Fuchsbauer Prof. Dr. Harald Kolmar 《Angewandte Chemie (International ed. in English)》2015,54(45):13420-13424
Based on the crystal structure of a natural protein substrate for microbial transglutaminase, an enzyme that catalyzes protein crosslinking, a recognition motif for site‐specific conjugation was rationally designed. Conformationally locked by an intramolecular disulfide bond, this structural mimic of a native conjugation site ensured efficient conjugation of a reporter cargo to the therapeutic monoclonal antibody cetuximab without erosion of its binding properties. 相似文献
897.
Controlled Light‐Mediated Preparation of Gold Nanoparticles by a Norrish Type I Reaction of Photoactive Polymers
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Florian Mäsing Dr. Artur Mardyukov Carsten Doerenkamp Prof. Dr. Hellmut Eckert Ursula Malkus Harald Nüsse Prof. Dr. Jürgen Klingauf Prof. Dr. Armido Studer 《Angewandte Chemie (International ed. in English)》2015,54(43):12612-12617
Gold nanoparticles (AuNPs) are subjects of broad interest in scientific community due to their promising physicochemical properties. Herein we report the facile and controlled light‐mediated preparation of gold nanoparticles through a Norrish type I reaction of photoactive polymers. These carefully designed polymers act as reagents for the photochemical reduction of gold ions, as well as stabilizers for the in situ generated AuNPs. Manipulating the length and composition of the photoactive polymers allows for control of AuNP size. Nanoparticle diameter can be controlled from 1.5 nm to 9.6 nm. 相似文献
898.
Olivia Schimming Dr. Victoria L. Challinor Dr. Nicholas J. Tobias Dr. Hélène Adihou Peter Grün Laura Pöschel Dr. Christian Richter Prof. Dr. Harald Schwalbe Prof. Dr. Helge B. Bode 《Angewandte Chemie (International ed. in English)》2015,54(43):12702-12705
Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non‐ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram‐negative and Gram‐positive bacteria indicates an important biological function in bacteria. 相似文献
899.
Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions
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Dr. Angie Garcia Douglas A. L. Otte Dr. Walter A. Salamant Jillian R. Sanzone Prof. K. A. Woerpel 《Angewandte Chemie (International ed. in English)》2015,54(10):3061-3064
In contrast to observations with carbohydrates, experiments with 4‐alkoxy‐substituted acetals indicate that an alkoxy group can accelerate acetal hydrolysis by up to 20‐fold compared to substrates without an alkoxy group. The acceleration of ionization in more flexible acetals can be up to 200‐fold when compensated for inductive effects. 相似文献
900.
Heidi-Kristin Walter Peggy R. Bohländer Prof. Dr. Hans-Achim Wagenknecht 《ChemistryOpen》2015,4(2):92-96
DNA-based aptamers are commonly used recognition elements in biosensors for a range of target molecules. Here, the development of a wavelength-shifting optical module for a DNA-based adenosine-binding aptamer is described. It applies the combination of two photostable cyanine-styryl dyes as covalent modifications. This energy-transfer pair is postsynthetically attached to oligonucleotides via a copper(I)-catalyzed azide–alkyne cycloaddition by two structurally different approaches: 1) as nucleotide modifications at the 2′-position of uridines and 2) as nucleotide substitutions using (S)-amino-1,2-propanediol as acyclic linker between the phosphodiester bridges. Both dyes exhibit a remarkable photostability. A library of DNA aptamers consisting of different combinations of the two dyes in diagonal orientations were evaluated by their emission color contrast as readout. Further optimization led to aptasensors with improved fluorescent readout as compared with previously reported aptasensors. This approach described is synthetically facile using simple propargylated phosphoramidites as DNA building blocks. As such, this approach could be applied for other dyes and other chemical/biological applications. 相似文献