Measurement of the branching fraction, polarization, and asymmetry for decays, and determination of the Cabibbo-Kobayashi-Maskawa phase

We have measured the branching fraction , longitudinal polarization fraction f(L), and CP asymmetry coefficients A and S for B(0) --> rho(+) rho(-) decays with the Belle detector at the KEKB e(+) e(-) collider using 253 Fb(-1) of data. We obtain B = [22.8 +/- 3.8(stat)(+2.3)(-2.6)(syst)] x 10(-6), f(L) = 0.941 (+0.034)(-0.040)(stat) +/- 0.030(syst). A = 0.00 +/- 0.30(stat) +/- 0.09(syst) and S = 0.08 +/- 0.09(syst). These values are used to constrain the Cabibbo-Kobayashi-Maskawa phase ; the solution consistent with the standard model is phi(2) = (88 +/- 17) degrees or 59 degrees < phi(2) < 115 degrees at 90% C.L.     

Deferoxamine Iron Chelation Increases δ-Aminolevulinic Acid Induced Protoporphyrin IX in Xenograft Glioma Model

Exogenous administration of δ-aminolevulinic acid (δ-ALA) leads to selective accumulation of protoporphyrin IX (PpIX) in brain tumors, and has shown promising results in increasing extent of resection in fluorescence-guided resection (FGR) of brain tumors. However, this approach still suffers from heterogeneous staining and so some tumor margins may go undetected because of this variation in PpIX production. The aim of this study was to test the hypothesis that iron chelation therapy could increase the level of fluorescence in malignant glioma tumors. Mice implanted with xenograft U251-GFP glioma tumor cells were given a 200 mg kg⁻¹ dose of deferoxamine (DFO), once a day for 3 days prior to δ-ALA administration. The PpIX fluorescence observed in the tumor regions was 1.9 times the background in animal group without DFO, and 2.9 times the background on average, in the DFO pre-treated group. A 50% increase in PpIX fluorescence contrast in the DFO group was observed relative to the control group (t-test P-value = 0.0020). These results indicate that iron chelation therapy could significantly increase δ-ALA-induced PpIX fluorescence in malignant gliomas, pointing to a potential role of iron chelation therapy for more effective FGR of brain tumors.     

Stabilization of a steady state in oscillators coupled by a digital delayed connection

We propose the mapping of polynomial of degree 2S constructed as a linear combination of powers of spin-S (for simplicity, we called as spin-S polynomial) onto spin-crossover state. The spin-S polynomial in general can be projected onto non-symmetric degenerated spin up (high-spin) and spin down (low-spin) momenta. The total number of mapping for each general spin-S is given by 2(2^2S ? 1). As an application of this mapping, we consider a general non-bilinear spin-S Ising model which can be transformed onto spin-crossover described by Wajnflasz model. Using a further transformation we obtain the partition function of the effective spin-1/2 Ising model, making a suitable mapping the non-symmetric contribution leads us to a spin-1/2 Ising model with a fixed external magnetic field, which in general cannot be solved exactly. However, for a particular case of non-bilinear spin-S Ising model could become equivalent to an exactly solvable Ising model. The transformed Ising model exhibits a residual entropy, then it should be understood also as a frustrated spin model, due to competing parameters coupling of the non-bilinear spin-S Ising model.     

Examining Supervised Machine Learning Methods for Integer Link Weight Prediction Using Node Metadata

With the goal of understanding if the information contained in node metadata can help in the task of link weight prediction, we investigate herein whether incorporating it as a similarity feature (referred to as metadata similarity) between end nodes of a link improves the prediction accuracy of common supervised machine learning methods. In contrast with previous works, instead of normalizing the link weights, we treat them as count variables representing the number of interactions between end nodes, as this is a natural representation for many datasets in the literature. In this preliminary study, we find no significant evidence that metadata similarity improved the prediction accuracy of the four empirical datasets studied. To further explore the role of node metadata in weight prediction, we synthesized weights to analyze the extreme case where the weights depend solely on the metadata of the end nodes, while encoding different relationships between them using logical operators in the generation process. Under these conditions, the random forest method performed significantly better than other methods in 99.07% of cases, though the prediction accuracy was significantly degraded for the methods analyzed in comparison to the experiments with the original weights.     

N-Rich,Polyphenolic Porous Organic Polymer and Its In Vitro Anticancer Activity on Colorectal Cancer

N-rich organic materials bearing polyphenolic moieties in their building networks and nanoscale porosities are very demanding in the context of designing efficient biomaterials or drug carriers for the cancer treatment. Here, we report the synthesis of a new triazine-based secondary-amine- and imine-linked polyphenolic porous organic polymer material TrzTFPPOP and explored its potential for in vitro anticancer activity on the human colorectal carcinoma (HCT 116) cell line. This functionalized (-OH, -NH-, -C=N-) organic material displayed an exceptionally high BET surface area of 2140 m² g⁻¹ along with hierarchical porosity (micropores and mesopores), and it induced apoptotic changes leading to high efficiency in colon cancer cell destruction via p53-regulated DNA damage pathway. The IC30, IC50, and IC70 values obtained from the MTT assay are 1.24, 3.25, and 5.25 μg/mL, respectively.     

One-year Ocular Safety Observation of Workers and Estimations of Microorganism Inactivation Efficacy in the Room Irradiated with 222-nm Far Ultraviolet-C Lamps

Two krypton-chloride germicidal excimer lamp units (Care222 TRT-104C11-UI-U3, USHIO Inc.) were installed in the examination room of an ophthalmology department. The irradiation dose was set not to exceed the former (i.e., before 2022) threshold limit value (TLV) (22 mJ cm⁻²/8 h) recommended by the ACGIH. Section 1: The eyes and lids of the six ophthalmologists (5 wore glasses for myopic correction) who worked in the room for a mean stay of 6.7 h week⁻¹ were prospectively observed for 12 months. Slitlamp examinations revealed neither acute adverse events such as corneal erosion, conjunctival hyperemia, and lid skin erythema nor chronic adverse events such as pterygium, cataract, or lid tumor. The visual acuity, refractive error, and corneal endothelial cell density remained unchanged during the study. Section 2: The irradiation of samples placed on the table or floor using the same fixtures in the room (5–7.5 mJ cm⁻²) was associated with >99% inhibition of φX174 phage and >90% inhibition of Staphylococcus aureus. In conclusion, no acute or chronic health effects in human participants was observed in a clinical setting of full-room ultraviolet germicidal irradiation by 222-nm lamp units, and high efficacy in deactivation of microorganisms was determined in the same setting.