Induction of Apoptosis and Regulation of MicroRNA Expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) Treatment on MCF-7 Breast Cancer Cells

(2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) is a synthetic curcumin analogue, which has been reported to possess anti-tumor, anti-metastatic, and anti-invasion properties on estrogen receptor (ER) negative breast cancer cells in vitro and in vivo. However, the cytotoxic effects of BHMC on ER positive breast cancer cells were not widely reported. This study was aimed to investigate the cytotoxic potential of BHMC on MCF-7 cells using cell viability, cell cycle, and apoptotic assays. Besides, microarray and quantitative polymerase chain reaction (qPCR) were performed to identify the list of miRNAs and genes, which could be dysregulated following BHMC treatment. The current study discovered that BHMC exhibits selective cytotoxic effects on ER positive MCF-7 cells as compared to ER negative MDA-MB-231 cells and normal breast cells, MCF-10A. BHMC was shown to promote G2/M cell cycle arrest and apoptosis in MCF-7 cells. Microarray and qPCR analysis demonstrated that BHMC treatment would upregulate several miRNAs like miR-3195 and miR-30a-3p and downregulate miRNAs such as miR-6813-5p and miR-6132 in MCF-7 cells. Besides, BHMC administration was also found to downregulate few tumor-promoting genes like VEGF and SNAIL in MCF-7. In conclusion, BHMC induced apoptosis in the MCF-7 cells by altering the expressions of apoptotic-regulating miRNAs and associated genes.     

Toeplitz Operators and Herz Spaces on the Half-Space

On the setting of the half-space we introduce the Schatten-Herz classes of Toeplitz operators and obtain characterizations for positive Toeplitz operators to belong to those classes. We also prove results concerning the boundedness and compactness of Toeplitz operators with Herz symbols. Such a study has been recently done on the ball. At a critical step of the proofs we employ a much simplified argument to extend the range of parameters for Herz spaces on which the Berezin transform is bounded. Our results show not only that most of results on the ball continue to hold, but also that there is some pathology caused by the unboundedness of the domain. The first author was in part supported by a Korea University Grant(2007), the second author was in part supported by Hanshin University Research Grant, and both authors were in part supported by KOSEF(R01-2003-000-10243-0).     

Interactions of multiple spark-generated bubbles with phase differences

This paper aims to study the complex interaction between multiple bubbles, and to provide a summary and physical explanation of the phenomena observed during the interaction of two bubbles. High-speed photography is utilized to observe the experiments involving multiple spark-generated bubbles. Numerical simulations corresponding to the experiments are performed using the Boundary Element Method (BEM). The bubbles are typically between 3 and 5 mm in radius and are generated either in-phase (at the same time) or with phase differences. Complex phenomena are observed such as bubble splitting, and high-speed jetting inside a bubble caused by another collapsing bubble nearby (termed the ‘catapult’ effect). The two-bubble interactions are broadly classified in a graph according to two parameters: the relative inter-bubble distance and the phase difference (a new parameter introduced). The BEM simulations provide insight into the physics, such as bubble shape changes in detail, and jet velocities. Also presented in this paper are the experimental results of three bubble interactions. The interesting and complex observations of multiple bubble interaction are important for a better understanding of real life applications in medical ultrasonic treatment and ultrasonic cleaning. Many of the three bubble interactions can be explained by isolating bubble pairs and classifying their interaction according to the graph for the two bubble case. This graph can be a useful tool to predict the behavior of multiple bubble interactions.     

Gleason's problem for harmonic Bergman and Bloch functions on half-spaces

On the setting of the half-spaceR ^n–1×R ₊, we investigate Gleason's problem for harmonic Bergman and Bloch functions. We prove that Gleason's problem for the harmonicL ^p -Bergman space is solvable if and only ifp>n. We also prove that Gleason's problem for the harmonic (little) Bloch space is solvable.     

Adhesion property of polyolefin part for mobile device

Abstract

The value of the critical surface tension(γ_c.0) of the polyolefin part calculated by Zismann plot was 26.1?dyne/cm. The surface state and the γ_c,0 of the polyolefin part were changed by solvent treatment. Polyolefin part was influenced by solubility parameter of a solvent, on the other hand the degree of change in the surface state was dependent on a surface tension of a solvent. When a surface tension of solvent is lower than γ_c.0 of the polyolefin part, the wettability of a solvent was good and the surface state was greatly changed. The adhesion strength of polyolefin part was greatly improved to as compared to that of the untreated one. As the γ_c,0 of polyolefin part was closed to the surface tension of the primer, the good adhesion strength was obtained for γ_c/γ_L,p ≤1.     

Compact Differences of Composition Operators over Polydisks

Moorhouse characterized compact differences of composition operators acting on a weighted Bergman space over the unit disk of the complex plane. She also found a sufficient condition for a single composition operator to be a compact perturbation of the sum of given finitely many composition operators and studied the role of second order data in determining compact differences. In this paper, based on the characterizations due to Stessin and Zhu, of boundedness and compactness of composition operators acting from a weighted Bergman space into another, we obtain the polydisk analogues of Moorhouse’s results through a different approach in main steps. In addition we find a necessary coefficient relation for compact combinations which was first noticed on the disk by Kriete and Moorhouse.     

Effects of annealing on ion-implanted Si for interdigitated back contact solar cell

Effects of annealing on the properties of P- and B-implanted Si for interdigitated back contact (IBC) solar cells were investigated with annealing temperature of from 950 to 1050 °C. P-implanted samples annealed at 950 °C were enough to activate dopants and recover the damage by implantation. As the annealing temperature was increased, the diode properties of P-implanted samples were degraded, while that of B-implanted samples were improved. However, in order to activate an implanted B ion, B-implanted samples needed an annealing of above 1000 °C. The implied V_oc of lifetime samples by quasi-steady-state photoconductance decay followed the trend of diode properties on annealing temperature. Finally, IBC cell was fabricated with a two-step annealing at 1050 °C for B of the emitter and 950 °C for P of the front and back surface fields. The IBC cell had V_oc of 618 mV, J_sc of 35.1 mA/cm², FF of 78.8%, and the efficiency of 17.1% without surface texturing.     

Linear sums of two composition operators on the Fock space

Linear sums of two composition operators of the multi-dimensional Fock space are studied. We show that such an operator is bounded only when both composition operators in the sum are bounded. So, cancelation phenomenon is not possible on the Fock space, in contrast to what have been known on other well-known function spaces over the unit disk. We also show the analogues for compactness and for membership in the Schatten classes. For linear sums of more than two composition operators the investigation is left open.