Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans

Research on Chemical Intermediates - We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe3O4 nanoparticles....     

Lewis Acid Guests in a {P8W48} Archetypal Polyoxotungstate Host: Enhanced Proton Conductivity via Metal‐Oxo Cluster within Cluster Assemblies

Complexes made by hosts that completely surround their guests provide a means to stabilize reactive chemical intermediates, transfer biologically active cargo to a diseased cell, and construct molecular‐scale devices. By the virtue of inorganic host–guest self‐assembly, nucleation processes in the cavity of a {P₈W₄₈}‐archetype phosphotungstate has afforded a nanoscale 16‐Al^III‐32‐oxo cluster and its Ga^III analogue that contain the largest number of Al^III/Ga^III ions yet found in polyoxometalate (POM) chemistry. Interestingly, the rich Lewis acid Al^III centers within the Lewis base POM support shows an exceptional proton conductivity of 4.5×10^?2 S cm^?1 (85 °C, 70 % RH; RH: relative humidity), which is by far the highest conductivity reported among POM‐based single‐crystal proton conductors.     

C0 FE model based on HOZT for the analysis of laminated soft core skew sandwich plates: Bending and vibration

Bending and free vibration behaviour of laminated soft core skew sandwich plate with stiff laminate face sheets is investigated using a recently developed C₀ finite element (FE) model based on higher order zigzag theory (HOZT) in this paper. The in-plane displacement fields are assumed as a combination of a linear zigzag function with different slopes at each layer and a cubically varying function over the entire thickness. The out of plane displacement is considered to be quadratic within the core and constant in the face sheets. The plate theory ensures a shear stress-free condition at the top and bottom surfaces of the plate. Thus, the plate theory has all of the features required for accurate modelling of laminated skew sandwich plates. As very few element model based on this plate theory (HOZT) exist and they possess certain disadvantages, an attempt has been made to check the applicability of the refined element model. The nodal field variables are chosen in such a manner that there is no need to impose any penalty stiffness in the formulation. Refined C₀ finite element model has been utilized to study some interesting problems on static and free vibration analysis of laminated skew sandwich plates.     

Transition metal complexes of 6‐mercaptopurine: Characterization,Theoretical calculation,DNA‐Binding,molecular docking,and anticancer activity

6‐mercaptopurine (6‐MP) is used for treating various cancers and autoimmune disorders. A few examples of transition metal complexes of 6‐MP have been shown to enhance its anticancer activity, but many remain untested. We isolated five highly stable and colored metal complexes of 6‐MP and confirmed their structures by elemental analysis, spectral, and thermal techniques. Infrared (IR) spectra revealed that 6‐MP is a bidentate ligand that interacts through sulfur and pyrimidine nitrogen in a 1:2 (M:L) molar ratio. The magnetic susceptibility and electron paramagnetic resonance (EPR) spectra for the Cu(II) complex revealed an octahedral arrangement around the metal ion with strong covalent bonding. The fully optimized geometries of the metal structures obtained using density function theory (DFT)/B3LYP calculations were used to verify the structural and biological features. DNA titration revealed that the octahedral Cu(II) complex has a critical binding constant value of K_b = 8 × 105. Docking studies using three different cancer protein receptors were used to predict the biological applications of the synthesized drug‐metal complexes. Finally, cytotoxicity assays against a myeloma cancer cell line (MM) and a colon cancer cell line (Caco‐2) revealed favorable anticancer activity for the copper complex, exceeding that of the gold‐standard chemotherapeutic cisplatin.     

Simulation and demonstration of electro-optic digital logic gates based on a single microring resonator

We propose and demonstrate directed optical digital logic function which can perform several logic gates using a single microring resonator. The mode operations achieved are logic buffer, inverter, AND, NAND, OR and NOR operations. Numerical simulations, in order to analyze its static as well as dynamic responses, are carried out. In addition, we also present the fundamental numerical principles used by the simulation software in order to fully justify the simulation results. These principles are divided into three components, structure based free carrier distribution principles, change in refractive index of the waveguide and the scattering analysis on the microring resonator coupling region.     

Reconfigurable wideband to narrowband antenna using tunable EBG structure

In this paper, frequency reconfigurable electromagnetic band gap (EBG) structure that integrates with a wideband antenna is proposed. The EBG structure consists of a circular patch shorted to the ground plane and a secondary circular patch connected to the circular patch. Switches are positioned between the via and the ground plane and by controlling the state of the switch, the band-stop operation of the EBG can be activated or deactivated. In order to control the single and dual band-stop operation, another switch is place between the circular patch and the secondary circular patch. The EBG structure is then placed underneath the feed line of a wideband antenna. The antenna is capable of reconfiguring to three different frequency bands. The proposed antenna has the potential to provide useful features for the wireless communication applications.