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591.
This work aimed to synthesize a new antihyperglycemic thiazolidinedione based on the spectral data. The DFT\B3LYP\6-311G** level of theory was used to investigate the frontier molecular orbitals (FMOs), chemical reactivity and map the molecular electrostatic potentials (MEPs) to explain how the synthesized compounds interacted with the receptor. The molecular docking simulations into the active sites of PPAR-γ and α-amylase were performed. The in vitro potency of these compounds via α-amylase and radical scavenging were evaluated. The data revealed that compounds (4–6) have higher potency than the reference drugs. The anti-diabetic and anti-hyperlipidemic activities for thiazolidine-2,4-dione have been investigated in vivo using the alloxan-induced diabetic rat model along with the 30 days of treatment protocol. The investigated compounds didn’t show obvious reduction of blood glucose during pre-treatments compared to diabetic control, while after 30 days of treatments, the blood glucose level was lower than that of the diabetic control. Compounds (4–7) were able to regulate hyperlipidemia levels (cholesterol, triglyceride, high-density lipoproteins and low- and very-low-density lipoproteins) to nearly normal value at the 30th day.  相似文献   
592.
Molecular Diversity - A novel series of 1,2,3-triazolo-benzodiazepine derivatives 6a–o has been synthesized and evaluated in vivo for their anticonvulsant activities using by...  相似文献   
593.
The kinetics of the reactions of 2-chloro-3-nitropyridine (ortho-like) and 5-nitro (para-like) isomer with morpholine and piperidine were studied in methanol and benzene at several amine concentrations and temperatures in the range 25–45°C. The data show that k/k ratios are less than unity in methanol. The steric hindrance in the transition state of the 3-nitro (ortho-like) isomer retards o-substitution while the stability of p-quinonoid structure of the 5-nitro (para-like) isomer favors p-substitution. In benzene, the k3-NO2/k5-NO2 ratios are greater than unity. The hydrogen bonding formation between the ammonium hydrogen and the ortho-nitro group in the transition state of 3-nitro isomer favors the o-substitution. © 1997 John Wiley & Sons, Inc.  相似文献   
594.
The dissociation constant values of glycylglycine were determined at 25 ± 0.1 °C (I = 0.1 mol L?1 KNO3) with Potentiometric pH titration in pure water and various mixture of water and organic solvents. The organic solvents used were methanol, ethanol, N, N-dimethylformamide, dimethylsulfoxide, acetonitrile and dioxane. Initial estimates of the dissociation constants of glycylglycine were refined with ESAP2M computer program. The results obtained are discussed in terms of average macroscopic properties of the mixed solvents and the possible variation in microheterogeneity of the solvation shells around the solute.  相似文献   
595.
596.
Speciation analyses are of increasing interest in the environmental, toxicological and analytical fields, because the toxicity and reactivity of trace elements depend strongly on the chemical forms in which they are present. A simple electrodeposition–electrothermal atomic absorption spectrometry method for speciation analysis of some organic and inorganic selenium species in typical environmental water and agricultural soil samples has been developed. The method is based on the selective reduction of water-soluble Se(IV) and selenocystine (Se–Cys) species by an uncontrolled applied potential (1.8 V) on a mercury-coated electrode. In acidic media (1.0 M HCl solution) the only inorganic selenium species electrodeposited was Se(IV), and, of the water-soluble organic selenium species Se–Cys and Se–Met only Se–Cys was electrodeposited onto the mercury electrode surface. The proposed methodology was successfully applied to the speciation and determination of selenium in a few environmental samples. The spiked recovery value varied between 91% and 99%. The suggested method has been shown to have a characteristic mass (m0) of 25 pg, a limit of detection (LOD) of 1.0 μg L− 1 and a relative standard deviation (RSD%) of 3.5% for 6 measurements at a concentration of 100 μg L− 1 Se(VI).  相似文献   
597.
The electron impact tandem mass spectrometry of 3- and 5-nitropyridinylaryl sulfides are reported and discussed. The [M-1](+) ion is observed as the base peak for all the 5-nitropyridinylaryl sulfides, series I, whereas the 2-mercapto-3-nitrosopyridine fragment at m/z 139 represents the base peak for the 3-nitro isomers, series II, with the exception of the 3-substituted derivatives and the unsubstituted parent sulfide. The proposed fragmentation processes are substantiated by tandem mass spectrometry (MS/MS). Hammett correlation analysis of the substituent effect on the formation of fragments [RH(4)C(6)S](+), [C(6)H(4)R](+) and [M-HNO(2)](+) is discussed. Copyright 2000 John Wiley & Sons, Ltd.  相似文献   
598.
The acid dissociation constants of the protonated form of diimine heterocyclic compounds (imidazole, 2-methylimidazole, 2,2-bipyridyl, and 1,10-phenanthroline) were determinedpH-meterically in aqueous media containing different amounts of organic solvents, viz. amphiprotic (methanol, ethanol), dipolar aportic (DMSO), and low basic aprotic (acetonitrile) at 25±0.1 °C. It was observed that by increasing the amount of alcohol orDMSO in the aqueous medium thepK a, values of the investigated compounds decreased. On the other hand, thepK a values increased as the amount of acetonitrile in the medium was increased. These results are discussed in terms of various solvent characteristics. It is concluded that solvent effects, viz. differences in stabilization of the free base by dispersion forces and of the proton by its interaction with solvent molecules in amphiprotic or dipolar aprotic solvent-aqueous media relative to that in pure aqueous one, as well as the basicity effect of acetonitrile play a vital role in the ionisation equilibria of the investigated compounds.
Mediumeffekte auf die Säuredissoziationskonstanten einiger heterocyclischer Diimin-Basen
Zusammenfassung Die Säuredissoziationskonstanten der protonierten Formen der heterocyclischen Dimin-Basen Imidazol, 2-Methylimidazol, 2,2-Bipyridyl und 1,10-Phenanthrolin wurdenpH-metrisch in wäßrigem Medium mit einem Anteil an organischen Lösungsmitteln bei 25±0.1 °C bestimmt. Dabei wurden als amphiprotische Zusätze Methanol und Ethanol, als dipolar aprotisches organisches LösungsmittelDMSO und als aprotisches niederer Basizität Acetonitril ausgewählt. Es wurde beobachtet, daß bei ansteigenden Konzentrationen an Alkohol oderDMSO diepK a-Werte der untersuchten Verbindungen kleiner werden. Andererseits bewirkt Acetonitril ein Ansteigen derpK a-Werte. Die Ergebnisse werden mittels verschiedener Lösungsmittelparameter diskutiert. Lösungsmitteleffekte wie Stabilisierung der freien Base mittels Dispersionskräften, Protonwechselwirkungen in den verschiedenen Lösungsmittelgemischen und Basizitätseffekte des Acetonitril spielen dabei eine entscheidende Rolle.
  相似文献   
599.
Summary The UV/Vis spectroscopic behaviour of six new hydroxy azocoumarin compounds in solution has been investigated. The observed bands are assigned to electronic transitions. Azocoumarin compounds exist mainly in the azo form, whereas 6-(2-hydroxy-6-aminonaphthyl-1-azo)-coumarin exhibits an azo-hydrazone tautomeric equilibrium. The solvatochromic behaviour of the azo compounds is investigated by studying their spectra in pure and mixed organic solvents of different characteristics. The longer wavelength band of the azocoumarins inDMF solution is assigned to an intermolecular CT transition.
UV/Vis-spektroskopisches Verhalten einiger neuer Hydroxyazocumarinderivate
Zusammenfassung Das UV/Vis-spektroskopische Verhalten von sechs neuen Hydroxyazocumarinen in Lösung wurde untersucht. Die beobachteten Banden werden elektronischen Übergängen zugeordnet. Azocumarine liegen hauptsächlich in der Azoform vor, während 6-(2-Hydroxy-6-aminonaphthyl-1-azo)-cumarin eine Azo-Hydrazon-Tautomerie zeigt. Das solvatochrome Verhalten der Azoverbindungen wird durch Messung ihrer Spektren in reinen und gemischten organischen Lösungsmitteln mit unterschiedlichen Eigenschaften studiert. Die bei inDMF gelösten Azocumarinen auftretende langwellige Bande wird einem intermolekularen CT-Übergang zugeordnet.
  相似文献   
600.
Stoichiometry and equilibrium study of copper‐ligands including mercaptobenzoxazole (MBO), 4‐propyl 2‐thiouracyl (PTU), methyl‐2‐pyridylketone oxime (MPKO), phenyl‐2‐pyridylketone oxime (PPKO), 4,6‐dihydroxy‐2‐mercaptopyrimidine (DHMP), N,N′‐phenylene bis(salicylaldimine) (PBS) and 1,2‐bis(2‐hydroxyphenyl)naphtaldiimine (BHNPDI) were conducted in aqueous and nonaqueous solution by potentiometry and spectrophotometry. Stability constants of the complexes are determined at 25 ± 1 °C and 0.1 or 0.05 M ionic strength in water or acetonitrile solvents. Oximes ligand protonation constants and copper‐ligands complexes' stability and hydrolysis constants were calculated using the BEST program in aqueous solution. The stability constants of copper‐ligands complexes were calculated using the KINFIT program in acetonitrile solution. The results of these two methods are made self‐consistent, then rationalized assuming an equilibrium model including the species, ML, MLH, MLOH and ML2 (where the charges of the species have been ignored for the sake of simplicity) (L = MBO, PTU, MPKO, PPKO, DHMP, BHNPDI and PBS).  相似文献   
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