Indirubin Derivatives Modulate TGFβ/BMP Signaling at Different Levels and Trigger Ubiquitin-Mediated Depletion of Nonactivated R-Smads

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Highlights? Inhibition of TGFβ/BMP signaling by degradation of nonactivated R-Smads ? Total R-Smad pools are regulated through the ubiquitin-proteasome pathway ? Ubiquitin proteases USP9x and USP34 interact directly with R-Smads ? Indirubin derivative E738 controls BMP/TGFβ signaling though R-Smad depletion     

Plasticity-triggered architectural effects in periodic multilayers with wavy microstructures

Despite considerable presence of periodic multilayers with wavy architectures in nature and technology, little simulation data is available on their response. A recent investigation of wavy multilayers comprised of alternating elastic and elastic-perfectly plastic plies has revealed the important role that plasticity plays on their post-yield response relative to the corresponding flat configurations [Khatam, H., Pindera, M.-J., 2009b. Parametric finite-volume micromechanics of periodic materials with elastoplastic phases. Int. J. Plasticity 25 (7), 1386–1411]. Herein, we extend this investigation by considering the effect of elastic layer thickness on the post-yield response at several fixed elastic phase volume fractions using the parametric finite-volume direct averaging micromechanics (FVDAM) theory. The layer thickness is shown to have a substantial impact on the post-yield response whose extent depends on the loading mode and waviness amplitude, in contrast with the minimal impact on the homogenized elastic moduli. Decreasing the layer thickness at sufficiently high fixed volume fractions decreases the extent of strain hardening under transverse normal loading, as well as the maximum normal and shear stresses in the stiff layers, reducing the possibility of failure and thus potentially enhancing durability. The opposite holds under transverse shear loading for low waviness amplitudes. The presented results provide a framework for tailoring the elastoplastic response of multilayers with sinusoidally varying plies under different loading modes.     

Observation of chimera patterns in a network of symmetric chaotic finance systems

The economic and financial systems consist of many nonlinear factors that make them behave as the complex systems. Recently many chaotic finance systems have been proposed to study the complex dynamics of finance as a noticeable problem in economics. In fact, the intricate structure between financial institutions can be obtained by using a network of financial systems. Therefore, in this paper, we consider a ring network of coupled symmetric chaotic finance systems, and investigate its behavior by varying the coupling parameters. The results show that the coupling strength and range have significant effects on the behavior of the coupled systems, and various patterns such as the chimera and multi-chimera states are observed. Furthermore, changing the parameters' values, remarkably influences on the oscillators attractors. When several synchronous clusters are formed, the attractors of the synchronized oscillators are symmetric, but different from the single oscillator attractor.     

Nonlinear study of the dynamic behavior of a string-beam coupled system under combined excitations

In this paper,the nonlinear dynamic behavior of a string-beam coupled system subjected to external,parametric and tuned excitations is presented.The governing equations of motion are obtained for the nonlinear transverse vibrations of the string-beam coupled system which are described by a set of ordinary differential equations with two degrees of freedom.The case of 1:1 internal resonance between the modes of the beam and string,and the primary and combined resonance for the beam is considered.The method of multiple scales is utilized to analyze the nonlinear responses of the string-beam coupled system and obtain approximate solutions up to and including the second-order approximations.All resonance cases are extracted and investigated.Stability of the system is studied using frequency response equations and the phase-plane method.Numerical solutions are carried out and the results are presented graphically and discussed.The effects of the different parameters on both response and stability of the system are investigated.The reported results are compared to the available published work.     

Separation of strontium and yttrium in nitric acid solutions using zirconium titanium phosphate and Dowex exchangers

Sulfonated ion irradiated (H⁺ and He²⁺) PEEK films were synthesized with a range of cross-linking density and a variety of sulfonation degrees. Batch adsorption experiments were carried out at an initial pH of 6.0 ± 0.2, initial concentrations of Pb²⁺ and ¹³⁷Cs ions of 10.0 mg L⁻¹ and 5500 Bq L⁻¹, respectively. The maximum adsorption capacity was 60 mg g⁻¹ for Pb²⁺, and the distribution coefficient reached 6200 cm³ g⁻¹ for ¹³⁷Cs. The results indicated that sulfonation could be used to recycle low cross-linked PEEK and prepare efficient adsorbents to remove toxic Pb²⁺ and ¹³⁷Cs from polluted aqueous solutions.

     

Antioxidants and Bioactive Compounds in Licorice Root Extract Potentially Contribute to Improving Growth,Bulb Quality and Yield of Onion (Allium cepa)

The increasing culinary use of onion (Alium cepa) raises pressure on the current production rate, demanding sustainable approaches for increasing its productivity worldwide. Here, we aimed to investigate the beneficial effects of licorice (Glycyrrhiza glabra) root extract (LRE) in improving growth, yield, nutritional status, and antioxidant properties of two high-yielding onion cultivars, Shandaweel and Giza 20, growing under field conditions in two consecutive years. Our results revealed that pretreatments of both onion cultivars with LRE exhibited improved growth indices (plant height and number of leaves) and yield-related features (bulb length, bulb diameter, and bulb weight) in comparison with the corresponding LRE-devoid control plants. Pretreatments with LRE also improved the nutritional and antioxidant properties of bulbs of both cultivars, which was linked to improved mineral (e.g., K⁺ and Ca²⁺) acquisition, and heightened activities of enzymatic antioxidants (e.g., superoxide dismutase, catalase, ascorbate peroxidase, glutathione peroxidase, and glutathione S-transferase) and increased levels of non-enzymatic antioxidants (e.g., ascorbic acid, reduced glutathione, phenolics, and flavonoids). LRE also elevated the contents of proline, total free amino acids, total soluble carbohydrates, and water-soluble proteins in both onion bulbs. In general, both cultivars displayed positive responses to LRE pretreatments; however, the Shandaweel cultivar performed better than the Giza 20 cultivar in terms of yield and, to some extent, bulb quality. Collectively, our findings suggest that the application of LRE as biostimulant might be an effective strategy to enhance bulb quality and ultimately the productivity of onion cultivars under field conditions.     

Optimization and effect of wall conduction on natural convection in a cavity with constant temperature heat source: Using lattice Boltzmann method and neural network algorithm

Journal of Thermal Analysis and Calorimetry - In this paper, the natural convection (NC) of the Al2O3–H2O nanofluids (NFs) in a cavity with a heat source in its center is numerically...     

A review on the properties,preparation, models and stability of hybrid nanofluids to optimize energy consumption

Journal of Thermal Analysis and Calorimetry - These days, the importance of energy consumption has led scientists to optimize thermal devices. One of the solutions proposed for this purpose is...     

Experiments on the sputtering of neutral Cu2 dimers from Cu by Ar+ ions (60–300 eV)

A planar polycrystalline copper target was bombarded normally by Ar⁺ ions with energies ranging from 60 to 300 eV. in the source of a mass spectrometer. The neutral particles sputtered normally from the target were post-ionized and analyzed in the mass spectrometer. A thermionically sustained, magnetically confined low pressure arc plasma was used to supply the bombarding ions, and for post-ionization of the neutral sputtered species. It was found that the relative yields of the sputtered neutral post-ionized Cu₂ dimers are linearly proportional to S², where S is the total sputtering yield for Ar⁺ -Cu. The results support the recombination model for the formation of neutral dimers in sputtering.     

Organocopper-based magnetically recoverable and reusable nanocatalyst for efficient synthesis of novel 1,2,3-triazole-based sulfonamides in green medium

Research on Chemical Intermediates - We report robust green synthesis of novel 1,2,3-triazole-based sulfonamides bearing different motifs such as fluorine under click conditions in presence of a...