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51.
Two azo-ene-butadiyne conjugated systems undergo CuCl-mediated cyclization to afford isoindazolyl carbenoids that could be trapped with 2,3-dimethyl-2-butene as [2+1] cycloaddition products. X-ray structure analysis of the resultant cyclopropanes showed that formal migration to the distal carbenoid isomer and subsequent trapping had occurred. The possible CuCl-induced cyclization/migration pathways were explored using density functional theory, which indicated that the reaction most likely occurred via coordination of CuCl to the distal alkyne bond. 相似文献
52.
Haley A. Wofford Josh Myers-Dean Brandon A. Vogel Kevin Alexander Estrada Alamo Frederick A. Longshore-Neate Filip Jagodzinski Jeanine F. Amacher 《Molecules (Basel, Switzerland)》2021,26(19)
Choanoflagellates are single-celled eukaryotes with complex signaling pathways. They are considered the closest non-metazoan ancestors to mammals and other metazoans and form multicellular-like states called rosettes. The choanoflagellate Monosiga brevicollis contains over 150 PDZ domains, an important peptide-binding domain in all three domains of life (Archaea, Bacteria, and Eukarya). Therefore, an understanding of PDZ domain signaling pathways in choanoflagellates may provide insight into the origins of multicellularity. PDZ domains recognize the C-terminus of target proteins and regulate signaling and trafficking pathways, as well as cellular adhesion. Here, we developed a computational software suite, Domain Analysis and Motif Matcher (DAMM), that analyzes peptide-binding cleft sequence identity as compared with human PDZ domains and that can be used in combination with literature searches of known human PDZ-interacting sequences to predict target specificity in choanoflagellate PDZ domains. We used this program, protein biochemistry, fluorescence polarization, and structural analyses to characterize the specificity of A9UPE9_MONBE, a M. brevicollis PDZ domain-containing protein with no homology to any metazoan protein, finding that its PDZ domain is most similar to those of the DLG family. We then identified two endogenous sequences that bind A9UPE9 PDZ with <100 μM affinity, a value commonly considered the threshold for cellular PDZ–peptide interactions. Taken together, this approach can be used to predict cellular targets of previously uncharacterized PDZ domains in choanoflagellates and other organisms. Our data contribute to investigations into choanoflagellate signaling and how it informs metazoan evolution. 相似文献
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Engle JM Lakshminarayanan PS Carroll CN Zakharov LN Haley MM Johnson DW 《Crystal growth & design》2011,11(11):5144-5152
The conformations of 2,6-bis(2-anilinoethynyl)pyridine-based urea receptors were studied by single crystal X-ray diffraction methods and revealed a rich conformational flexibility influenced by solvents. Whereas receptor L(1) in DMSO prefers an "S" conformation, receptor L(1) crystallizes in an "O" conformation from DMSO/CH(3)OH binary solvent system, and a "W" conformation in the ternary solvent mixture DMSO/toluene/1,4-dioxane. In the case of L(2), the molecule adopts an "S" conformation where water molecules are sandwiched between two molecules of L(2) to form a dimer. Similar to L(2), L(3) also forms a dimer where water molecules are sandwiched between L(3) molecules, which are capped with two molecules of DMSO. Such a capping DMSO solvate is lacking in the case of L(2). Taken together, these results demonstrate that the conformation of 2,6-bis(2-anilinoethynyl) pyridine-based urea receptors can be dramatically manipulated and tuned by the choice of crystallization solvents. 相似文献
57.
N. F. Haley 《Journal of heterocyclic chemistry》1977,14(7):1245-1247
The reaction of 2- or 4-methyl-2,6-diphenylpyrylium perchlorate with tetracyanoethylene (TCNE) in pyridine gives 2- or 4-(2,3,3-tricyanopropylidene)-2,6-diphenylpyran in good yield. Similar results are obtained from 2- or 4-methyl-2,6-diphenylthiapyrylium and 4-methylflavylium perchlorates. In one case a stable charge-transfer salt is isolated from the reaction of a methylene base and TCNE. The reaction mechanism of dye formation is discussed. 相似文献
58.
K.B. Haley 《European Journal of Operational Research》1985,20(2):269-271
59.
The linearized Ginzburg-Landau equation is solved exactly for a superconducting ring with an arbitrary number of dangling branches and transport currents. It is shown that dangling branches always enhance superconductivity. Finite port lengths couple the injected superfluid velocity to the circulating superfluid velocity which give rise to alternating normal and superconducting regions for certain temperature ranges as the magnetic field is varied. 相似文献
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