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11.
Becker-Szendy R Bratton CB Cady R Casper D Dye ST Gajewski W Goldhaber M Haines TJ Halverson PG Jones TW Kielczewska D Kropp WR Learned JG LoSecco JM Matsuno S McGrew C Mudan MS Price L Reines F Schultz J Sobel HW Stone JL Sulak LR Svoboda R Wittel F 《Physical review D: Particles and fields》1991,43(4):1413-1415
12.
Redesigning the DNA‐Targeted Chromophore in Platinum–Acridine Anticancer Agents: A Structure–Activity Relationship Study
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Dr. Amanda J. Pickard Dr. Fang Liu Thomas F. Bartenstein Laura G. Haines Dr. Keith E. Levine Prof. Gregory L. Kucera Prof. Ulrich Bierbach 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(49):16174-16187
Platinum–acridine hybrid agents show low‐nanomolar potency in chemoresistant non‐small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous genotoxicity of these agents and improve their pharmacological properties, a modular build–click–screen approach was used to evaluate a small library of twenty hybrid agents containing truncated and extended chromophores of varying basicities. Selected derivatives were resynthesized and tested in five NSCLC cell lines representing large cell, squamous cell, and adenocarcinomas. 7‐Aminobenz[c]acridine was identified as a promising scaffold in a hybrid agent ( P1–B1 ) that maintained submicromolar activity in several of the DNA‐repair proficient and p53‐mutant cancer models, while showing improved tolerability in mice by 32‐fold compared to the parent platinum–acridine ( P1–A1 ). The distribution and DNA/RNA adduct levels produced by the acridine‐ and benz[c]acridine‐based analogues in NCI‐H460 cells (confocal microscopy, ICP‐MS), and their ability to bind G‐quadruplex forming DNA sequences (CD spectroscopy, HR‐ESMS) were studied. P1–B1 emerges as a less genotoxic, more tolerable, and potentially more target‐selective hybrid agent than P1–A1 . 相似文献
13.
采用沉淀法制备前驱体,通过不同温度合成了上转换发光材料Y2O2S∶Er3+,Yb3+,运用XRD,SEM和上转换发射光谱对其进行表征。结果表明,所合成的Y2O2S∶Er3+Yb3+属于六方晶系晶体,随着合成温度的升高,产物的粒径不断增大,上转换发射光强度逐渐增加。研究Y2O2S∶Er3+Yb3+的上转换发光过程,红光发射和绿光发射分别源于Er3+离子的4F9/2→4I15/2以及2H11/2→4I15/2,4S3/2→4I15/2能级跃迁。利用群论计算了晶场中Er3+离子的能级分裂数目。 相似文献
14.
Michael J. Blandamer John Burgess Philip P. Duce Robert I. Haines Alexander McAuley 《Transition Metal Chemistry》1982,7(1):10-13
Summary Rate constants are reported for 12-tungstocobaltate(III) [CoW12O40]5– oxidation of iodide in water and in binary aqueous solvent mixtures containing up to 40% methanol, 40% acetonitrile, or 60% dimethyl sulphoxide. From these kinetic results, solubility measurements on potassium 12-tungstocobaltate(III), and published data on Gibbs free energies of transfer of appropriate ions, it has been deduced that the dominant factor in determining the marked decrease in rate observed on going from water into the binary aqueous solvent mixtures is destabilisation of the transition state for the electron-transfer reaction. 相似文献
15.
The absolute-retardation method of stress analysis has been developed and extended to the measurement of steady-state dynamic contact-stress distributions in an elastohydrodynamic rolling contact. The method has been shown to be applicable to the plane-strain conditions appearing in such a contact, and many of the difficulties of the technique associated with the use of conventional interferometers have been eliminated by forming the absolute-retardation interferogram from reflections at the front and back surfaces of an optically plane parallel birefringent model using a laser light source. Some results illustrating the success and limitations of the technique in the study of the elastohydrodynamic problem are discussed. 相似文献
16.
Isotopic substitution which lowers the symmetry of a molecule mixes normal modes of different symmetry. Relative signs of the anisotropies of polarizability derivatives associated with such modes may be obtained from the intensity distribution in the vib-rotational Raman spectrum of the lower symmetry species. The application to methane is given and a comparison of theory and experiment for CH2D2 is presented. 相似文献
17.
Daniel E. Haines Vincent M. Miskowski Michael D. Hopkins 《Journal of Cluster Science》2004,15(4):489-502
An analysis of the available electrochemical and electronic-sectroscopic data for quadruply metal–metal bonded complexes reveals that the 1(*) transition energy is an approximately linear function of the difference between the electrode potentials at which they are reduced and oxidized to the bond-order 3. 5 complexes. A theoretical framework for interpreting this correlation is provided by extending to the redox potentials a simple zero-differential-overlap model previously applied to 1(*) transition energies. It is suggested on the basis of this model that the simplicity of the empirical relationship between 1(*) energies and redox potentials is a consequence of the particular one- and two-electron energy terms that characterize these complexes; a linear relationship is not required by theory. 相似文献
18.
Haines J Chateau C Léger JM Bogicevic C Hull S Klug DD Tse JS 《Physical review letters》2003,91(1):015503
The cristobalitelike forms of the ternary silica analogues BPO4 and BAsO4 were investigated at high pressure by x-ray diffraction and theoretical methods. The behavior of these compounds represents an extreme case in which the tilt angle of the constituent tetrahedra increases in a spectacular way at high pressure resulting in a major change in topology from a cristobalitelike framework towards a "collapsed cristobalite" structure. These compounds provide the first examples of the collapse of a framework structure to a close-packed form in a continuous manner without an intervening phase transition. 相似文献
19.
Häussermann U Berastegui P Carlson S Haines J Léger JM 《Angewandte Chemie (International ed. in English)》2001,40(24):4624-4629
20.