Onset of quark-hadron duality in pion electroproduction

A large data set of charged-pion (pi+/-) electroproduction from both hydrogen and deuterium targets has been obtained spanning the low-energy residual-mass region. These data conclusively show the onset of the quark-hadron duality phenomenon, as predicted for high-energy hadron electroproduction. We construct several ratios from these data to exhibit the relation of this phenomenon to the high-energy factorization ansatz of electron-quark scattering and subsequent quark-->pion production mechanisms.     

条带式太阳帆的结构动力学分析

依靠光压推进,太阳帆被认为是最可行的星际探测航天器,太阳帆结构总体方案主要有两类:桅杆式和旋转式,其中,帆膜被分割成窄条的条带式太阳帆在桅杆式太阳帆中具有较为理想的结构效率,如何准确计算条带式太阳帆的结构动力学特性值得研究.本文对条带式太阳帆结构的振动特性和结构稳定性进行研究,将太阳帆看作是由若干个桅杆-膜带组件依次连接而成的整体结构,桅杆-膜带组件由4根桅杆段和4条薄膜条带组成,分段轴压作用下的桅杆与薄膜条带耦合振动.考虑帆面薄膜条带与支撑桅杆之间的耦合振动,采用分布传递函数法建立了的条带式太阳帆的结构动力学模型,推导了条带式太阳帆结构自由振动和失稳载荷的求解方法.研究表明:条带式太阳帆构型有利于提高太阳帆结构的整体刚度和结构稳定性,随着帆面薄膜条带数目的增加,太阳帆结构的振动频率和失稳载荷增大;随着帆面薄膜预应力的增大,太阳帆结构振动的基频减小,稳定性变差;随着支撑桅杆刚度的提高,太阳帆结构整体的振动频率和失稳载荷增大.本文建立的解析求解方法具有求解效率快和精度高的特点,为条带式太阳帆的结构设计和姿态控制提供了有力的分析工具.      

翼型大攻角状态下表面吸气驻涡增升的数值模拟实验

用数值模拟方法给出了翼型大攻角状态表面吸气后绕翼型流动的某些新现象并对流场的特性进行了机理性研究,其中包括吸气对翼型背风面分离涡的驻涡增升作用;吸气孔位置对流场的影响;不同吸气强度以及间歇式吸气的增升效应。数值模拟的出发方程为N-S方程,差分格式为Beam-Warming格式。数值实验表明:(1)吸气可有效地提高翼型大攻角状态下的升力;(2)在一定吸气强度下吸气可使翼型背风面上涡的非定常脱落现象消失从而起到驻涡作用;(3)吸气孔位置在翼面的中部附近增升效果较好;(4)在一定范围内吸气强度越强其升力越高;(5)间歇式吸气也可提高平均升力,但引起升力的波动。     

Lewis Acid Promoted Ruthenium(II)‐Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters

Ethers are of fundamental importance in organic chemistry and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds. In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity.     

A Molecular Platform for Multistate Near‐Infrared Electrochromism and Flip‐Flop,Flip‐Flap‐Flop,and Ternary Memory

A diruthenium complex with a redox‐active amine bridge has been designed, synthesized, and studied by single‐crystal X‐ray analysis and DFT and TDDFT calculations. It shows three well‐separated redox processes with exclusive near‐infrared (NIR) absorbance at each redox state. The electropolymerized film of a related vinyl‐functionalized complex displays multistate NIR electrochromism with low operational potential, good contrast ratio, and long retention time. Flip‐flop, flip‐flap‐flop, and ternary memories have been realized by using the obtained film (ca. 15–20 nm thick) with three electrochemical inputs and three NIR optical outputs that each displays three levels of signal intensity.     

A DFT study of CO<Subscript>2</Subscript> electrochemical reduction on Pb(211) and Sn(112)

Electrochemical reduction of CO2 has the benefit of turning greenhouse gas emissions into useful resources. We performed a comparative study of the electrochemical reduction of CO2 on stepped Pb(211) and Sn(112) surfaces based on the results of density functional theory slab calculations. We mapped out the potential energy profiles for electrochemical reduction of CO2 to formate and other possible products on both surfaces. Our results show that the first step is the formation of the adsorbed formate(HCOO*) species through an Eley-Rideal mechanism. The formate species can be reduced to HCOO- through a oneelectron reduction in basic solution, which produces formic acid as the predominant product. The respective potentials of forming HCOO* are predicted to be -0.72 and -0.58 V on Pb and Sn. Higher overpotentials make other reaction pathways accessible, leading to different products. On Sn(112), CO and CH4 can be generated at -0.65 V following formate formation. In contrast, the limiting potential to access alternative reaction channels on Pb(211) is -1.33 V, significantly higher than that of Sn.     

Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

Guanine-rich oligonucleotides (GROs) have attracted considerable attention as anticancer agents, because they exhibit cancer-selective antiproliferative activity and can form G-quadruplex structures with higher nuclease resistance and cellular uptake. Recently, a GRO, AS1411 has reached phase II clinical trials for acute myeloid leukemia and renal cell carcinoma. The antiproliferative activity of GROs has been associated with various protein targets; however the real mechanisms of action remain unclear. In this study, we showed evidence that antiproliferative activity of GROs (including AS1411) is mainly contributed by the cytotoxicity of their guanine-based degradation products, such as monophosphate deoxyguanosine (dGMP), deoxyguanosine (dG) and guanine. The GROs with lower nuclease resistance exhibited higher antiproliferative activity. Among nucleotides, nucleosides and nucleobases, only guanine-based compounds showed highly concentration-dependent cytotoxicity. Our results suggest that it is necessary to reconsider the cancer-selective antiproliferative activity of GROs. Since guanine-based compounds are endogenous substances in living organisms, systematic studies of the cytotoxicity of these compounds will provide new information for the understanding of certain diseases and offer useful information for drug design.