玄武岩/Kevlar纤维布填充防护结构撞击极限及损伤特性

为了研究玄武岩/Kevlar纤维布填充防护结构的撞击极限和损伤特性,采用非火药驱动二级轻气炮进行超高速撞击实验,拟合撞击极限曲线,并与Nextel/Kevlar填充防护结构及三层铝防护结构进行比较。结果表明:玄武岩/Kevlar填充防护结构具有和Nextel/Kevlar填充防护结构类似的防护效果,防护性能优于三层铝防护结构。进一步研究填充防护结构铝合金防护屏、纤维布填充层及铝合金舱壁的损伤形式,分析了造成防护屏、填充层与舱壁不同损伤形貌的原因,探索了玄武岩/Kevlar纤维布填充防护结构的防护机理,得出玄武岩纤维布填充层使弹丸碎化,而Kevlar填充层消耗、吸收和分散弹丸或碎片云的能量。     

智能水凝胶双抗癌药物控释体系

近年来,基于联合用药策略的双药物控释体系的研究为降低抗癌药物毒性和提高疗效提供了有效途径。水凝胶作为一类高临床应用价值的药物载体,在药物控释方面具有广泛的应用前景。癌症是危害人类健康和生命的疾病之一,当人体内正常细胞发生癌变后,癌变细胞周围会发生一些显著的变化。因此,根据肿瘤细胞与正常细胞在体内环境及体外环境的差异,发展了多种智能型水凝胶双抗癌药物控释载体。它能够在感知外界因素的刺激下发生内部结构的变化,从而实现对药物的可控释放。与此同时,随着新的治疗手段的兴起和更多抗癌作用靶点的发现,水凝胶载体也成功实现了化学药物和生物治疗因子的同时负载和可控释放。本文将从不同智能型水凝胶载体如何负载、控释双抗癌药物及水凝胶药物载体中药物的组合方式两方面综述智能型水凝胶双抗癌药物控释体系最新研究进展,并展望其发展前景。     

A study on a flexible wing with up–down vibration in a pulsating flow of cooling air to improve heat transfer efficiency

We investigated a flexible wing that can function as a folding fan by vibrating smoothly on a heated surface, and the effects of this vibration on heat transfer. For flexible up–down vibrations of the wing in a pulsating flow, we propose a novel milli-scale flexible wing shape with a relatively large body and a narrow connecting leg. The shape was optimized such that its deformation became much larger at a low air flow. We performed two-way fluid–structure interaction analyses to predict performance, and an experimental validation was also conducted. The details of flow, heat transfer, and structural deformation are summarized qualitatively. Our results show that the heat transfer coefficient of a heated surface with a single flexible wing was approximately 11.3 % greater than that of a flat plate.     

Matrix formalism and singular-value decomposition for the location of gamma interactions in segmented HPGe detectors

Modern coaxial and planar HPGe detectors allow a precise determination of the energies and trajectories of the impinging gamma-rays. This entails the location of the gamma interactions inside the crystal from the shape of the delivered signals. This paper reviews the state of the art of the analysis of the HPGe response function and proposes methods that lead to optimum signal decomposition. The generic matrix method allows fast location of the interactions even when the induced signals strongly overlap.     

Complexation of Cyclodextrins with Benzoic Acid in Water-Organic Solvents: A Solvation-Thermodynamic Approach

The aim of this research is to obtain new data about the complexation between β-cyclodextrin (β-CD) and benzoic acid (BA) as a model reaction of the complex formation of hydrophobic molecules with cyclodextrins (CDs) in various media. This research may help developing cyclodextrin-based pharmaceutical formulations through the choice of the appropriate solvent mixture that may be employed in the industrial application aiming to control the reactions/processes in liquid phase. In this paper, NMR results for the molecular complex formation between BA and β-CD ([BA⊂β-CD]) in D₂O-DMSO-d₆ and in D₂O-EtOH have shown that the stability of the complex in the H₂O-DMSO-d₆ varies within the experimental error, while decreases in H₂O-EtOH. Changes in the Gibbs energy of BA resolvation in water and water–dimethylsulfoxide mixtures have been obtained and have been used in the analysis of the reagent solvation contributions into the Gibbs energy changes of the [BA⊂β-CD] molecular complex formation. Quantum chemical calculations of the interaction energy between β-CD and BA as well as the structure of the [BA⊂β-CD] complex and the energy of β-CD and BA interaction in vacuum and in the medium of water, methanol and dimethylsulfoxide solvents are carried out. The stability of [BA⊂β-CD] complex in H₂O-EtOH and H₂O-DMSO solvents, obtained by different methods, are compared. The thermodynamic parameters of the [BA⊂β-CD] molecular complexation as well as the reagent solvation contributions in H₂O-EtOH and H₂O-DMSO mixtures were analyzed by the solvation-thermodynamic approach.     

The expected value models on Sugeno measure space

Uncertain programming is a theoretical tool to handle optimization problems under uncertain environment. The research reported so far is mainly concerned with probability, possibility, or credibility measure spaces. Up to now, uncertain programming realized in Sugeno measure space has not been investigated. The first type of uncertain programming considered in this study and referred to as an expected value model optimizes a given expected objective function subject to some expected constraints. We start with a concept of the Sugeno measure space. We revisit some main properties of the Sugeno measure and elaborate on the g_λ random variable and its characterization. Furthermore, the laws of the large numbers are discussed based on this space. In the sequel we introduce a Sugeno expected value model (SEVM). In order to construct an approximate solution to the complex SEVM, the ideas of a Sugeno random number generation and a Sugeno simulation are presented along with a hybrid approach.     

<Emphasis Type="Italic">H</Emphasis><Subscript>∞</Subscript> Control and Exponential Stability of Nonlinear Nonautonomous Systems with Time-Varying Delay

This paper addresses the design of H _∞ state feedback controllers for a class of nonlinear time-varying delay systems. The interesting features here are that the system in consideration is nonautonomous with fast-varying delays, the delay is also involved in the observation output, and the controllers to be designed satisfy some exponential stability constraints on the closed-loop poles. By using the proposed Lyapunov functional approach, neither a controllability assumption nor a bound restriction on nonlinear perturbations is required to obtain new sufficient conditions for the H _∞ control. The conditions are derived in terms of a solution to the standard Riccati differential equations, which allows for simultaneous computation of the two bounds that characterize the stability rate of the solution. This work was supported by the National Foundation for Science and Technology Development, Vietnam and the Center of Excellence for Autonnomous Systems funded by the Australian Research Council, Australia.     

EGF‐Loaded Hyaluronic Acid Based Microparticles as Effective Carriers in a Wound Model

Epidermal growth factor (EGF) is widely recognized to be involved in the regenerative process, but only a few studies document its effect on acute wounds when EGF release is sustained over a period of time by encapsulation in an emulsion‐based hydrogel. Among hydrogels, hyaluronic acid (HA) is a promising carrier because it is biodegradable and known to bind to the components of the Extracellular Matrix (ECM) which undergoes remodeling during regeneration. Coupled with EGF in microparticulates, it may serve to directly deliver the cytokine to the impaired ECM to stimulate cells for ECM remodeling. In this study, a very simple and effective way is demonstrated to produce EGF‐conjugated HA microspheres for the purpose of targeted and sustained EGF delivery to damaged ECM in acute wounds. This approach is advantageous due to its simplicity which may serve to accelerate research in wound regeneration and relevant drug discovery.     

Flocking Dynamics of Singularly Perturbed Oscillator Chain and the Cucker-Smale System

In this note, we show how the one-dimensional Cucker-Smale system for “flocking” dynamics can be recovered as a singular perturbation limit of a chain of damped oscillators.     

Bending properties of two- and three-dimensional-shaped nanoparticles fabricated via substrate conformal imprint lithography

Nanoimprinting enables the implementation of nanoparticle shapes with complex 2D shapes involving different materials. In addition to these objects, this article presents 3D-shaped nanoparticles fabricated by substrate conformal imprint technique. The imprint polymer AMONIL is used either in pure form or in combination with fluorescent dyes for the preparation of particles. The substrate conformal imprint lithography process, including etching and particle release, is conducted for both materials in a similar fashion. In this work, cuboidal particles with a high aspect ratio (1:120) are compared to particles with a T-shaped cross section with respect to their abilities to enhance or reduce their stiffness. Additionally, particles with a high aspect ratio are compared to particles with a lower aspect ratio (1:20). The local stiffness is found to depend strongly on the particle thickness and the geometry of their cross section. Thicker and 3D T-shaped particles present higher local stiffness than thinner and 2D cuboidal-shaped particles. The local bending angle was determined to be 77° for 2D-shaped particles and 83° for 3D-shaped particles, of the same total height of 176 nm. Very thin particles (<50 nm) of high aspect ratio prefer to curl finally forming loops.