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91.
Hyo‐Jung Park Eun‐Kyoung Bang Jung Joo Hong Sang‐Myeong Lee Hae Li Ko Hye Won Kwak Hyelim Park Kyung Won Kang Rhoon‐Ho Kim Seung Rok Ryu Green Kim Hanseul Oh Hye‐Jung Kim Kyuri Lee Minjeong Kim Soo Young Kim Jae‐Ouk Kim Karim El‐Baz Hyukjin Lee Manki Song Dae Gwin Jeong Gyochang Keum Jae‐Hwan Nam 《Angewandte Chemie (International ed. in English)》2020,59(28):11540-11549
As agonists of TLR7/8, single‐stranded RNAs (ssRNAs) are safe and promising adjuvants that do not cause off‐target effects or innate immune overactivation. However, low stability prevents them from mounting sufficient immune responses. This study evaluates the adjuvant effects of ssRNA derived from the cricket paralysis virus intergenic region internal ribosome entry site, formulated as nanoparticles with a coordinative amphiphile, containing a zinc/dipicolylamine complex moiety as a coordinative phosphate binder, as a stabilizer for RNA‐based adjuvants. The nanoformulated ssRNA adjuvant was resistant to enzymatic degradation in vitro and in vivo, and that with a coordinative amphiphile bearing an oleyl group ( CA‐O ) was approximately 100 nm, promoted effective recognition, and improved activation of antigen‐presenting cells, leading to better induction of neutralizing antibodies following single immunization. Hence, CA‐O may increase the efficacy of ssRNA‐based adjuvants, proving useful to meet the urgent need for vaccines during pathogen outbreaks. 相似文献
92.
Yesub Keum Bongkyeom Kim Asong Byun Prof. Dr. Jinhee Park 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(48):21775-21780
We present novel titanium-porphyrinic gels (TPGs) and titanium-porphyrinic aerogels (TPAs), in which porphyrinic ligand tetrakis(4-carboxyphenyl)porphyrin is coordinated to Ti-oxo clusters. These hierarchically porous TPAs, with micro-, meso-, and macropores and reactant-concentration-dependent Brunauer-Emmett-Teller surface areas of 407–738 m2 g−1, are prepared by CO2 critical point drying of TPGs. Although the Ti4+ → Ti3+ photoreduction of TPAs is less efficient than that of crystalline microporous Ti-porphyrinic framework DGIST-1, prompt diffusion of O2 and spin-trapping agents into the TPA pores causes the rapid generation of reactive oxygen species (ROS), as observed by EPR spectroscopy. When used as an ROS scavenger, large 1,3-diphenylisobenzofuran is degraded by the best-performing TPA 10 times faster than by DGIST-1, suggesting that the accessibility of molecules (reactants) to pores (reactive centers) strongly influences photocatalytic activity. 相似文献