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61.
Sample preparation is the critical step in analysis of residues in biological samples. The development of a ragged method is time-consuming, because a huge number of parameters must be checked. To reduce the number of experiments Taguchi's method was applied in the sample preparation of metabolites of albendazole. During the experiments 11 controllable and 7 noise factors were investigated. From the influence of controllable and noise factors on recovery and standard deviation, conditions for the sample preparation and recovery could be concluded with high accuracy and reliability. 相似文献
62.
63.
The flame retardant mechanism of a newly synthesized phosphorus-containing reactive amine, which can be used both as crosslinking agent in epoxy resins and as flame retardant, was investigated. The mode of action and degradation pathway were investigated by in situ analysis of the gases evolved during the degradation by thermogravimetric measurements coupled online with infrared (TG-EGA-FTIR) and mass spectroscopy (TG/DTA-EGA-MS) and by solid residue analysis by infrared (ATR) spectroscopic methods and X-ray photoelectron spectroscopy (XPS). It was observed that the main difference in the degradation of the reference and the flame retardant system is that the degradation of the latter begins at lower temperature mainly with the emission of degradation products of the phosphorus amine, which act as flame retardants in the gas phase slowing down the further degradation steps. At the high temperature degradation stage the solid phase effect of the phosphorus prevails: the formation of phosphorocarbonaceous intumescent char results in a mass residue of 23.4%. The ratio of phosphorus acting in gas phase and solid phase, respectively, was determined on the basis of thermogravimetric and XPS measurements. 相似文献
64.
Illingworth CJ Parkes KE Snell CR Ferenczy GG Reynolds CA 《The journal of physical chemistry. A》2008,112(47):12151-12156
The concept of model chemistries within hybrid QM/MM calculations has been addressed through analysis of the polarization energy determined by two distinct approaches based on (i) induced charges and (ii) induced dipoles. The quantum mechanical polarization energy for four configurations of the water dimer has been determined for a range of basis sets using Morokuma energy decomposition analysis. This benchmark value has been compared to the fully classical polarization energy determined using the induced dipole approach, and the molecular mechanics polarization energy calculated using induced charges within the MM region of hybrid QM/MM calculations. From the water dimer calculations, it is concluded that the induced charge approach is consistent with medium sized basis set calculations whereas the induced dipole approach is consistent with large basis set calculations. This result is highly relevant to the concept of QM/MM model chemistries. 相似文献
65.
Catalytic transfer hydrogenation of 2-butanone with 2-propanol was studied in gas phase over a series of oxides of different
acid-base properties. Although the basic oxides (MgO, La2O3) gave high initial conversions, these oxides underwent deactivation during the reaction. This deactivation could be partially
prevented by a previous treatment with chloroform of the oxide. The amphoteric oxides (TiO2, ZrO2, Al2O3) were also active in this reaction. Increasing the acidic character of the catalyst (Nb2O5, WO3) led to a pronounced dehydration of 2-propanol. The results obtained over a series of rare earth oxides (La2O3, Sm2O3, Gd2O3, Dy2O3, Er2O3) revealed that beside the role of basic and acid sites a correlation seems to exist between the number of unpaired electrons
of the metal ion and the catalytic activity, indicating the role of one electron donor sites. 相似文献
66.
Magyari K Bálint Z Simon V Váró G 《Journal of photochemistry and photobiology. B, Biology》2006,85(2):140-144
The function of three types of bacteriorhodopsins was compared: the wild-type, the bleached and retinal reconstituted and retinal deficient bacteriorhodopsin after retinal addition. The apparent pK(a) of the proton acceptor group for the bleached BR and retinal deficient BR shifted toward higher pH values compared to the wild-type BR. Fitting the photocycle model to the absorption kinetic signals for all three proteins showed the existence of the same intermediates, but the time-dependent concentration of the intermediates was different. Although measurements were made at pH 7, the absorption kinetics and photoelectric signals in both retinal reconstituted samples acted as wild-type bacteriorhodopsin at significantly higher pH. Below pH 3 the retinal deficient and reconstituted sample bleached. These results suggested that the added retinal was not able to rebind in the same position in the protein as in native bacteriorhodopsin. This points out that care should be taken, when bleached bacteriorhodopsin is reconstituted with different retinal analogs. 相似文献
67.
Á. Sebők A. Vasanits-ZsigraiA. Helenkár Gy. ZárayI. Molnár-Perl 《Journal of chromatography. A》2009,1216(12):2288-2301
This paper reports a multiresidue analysis procedure which permits the identification and quantification of sixty-three water-soluble pollutants. Subsequent to their solid-phase extraction (SPE) enrichment, analyses of species have been carried out from one solution, by a single injection, as their trimethylsilyl-oxime ether/ester derivatives, by gas chromatography–mass spectrometry, within 31 min. Based on our optimized extraction, derivatization and mass fragmentation studies separation have been performed in the total ion current mode, identification and quantification of compounds have been carried out on the basis of their selective fragment ions. Including various pharmaceuticals, benzoic acid, its substituted species, different aromatic carboxylic acids, cholic acids, unsaturated and saturated fatty acids, aliphatic dicarboxylic acids, as well as synthetic pollutants of various origins (2,4-di-tert-butylphenol, different phthalates). Standard compounds were added to 500 mL effluent wastewater samples, at three concentrations (1–5 μg/L, 5–10 μg/L and 10–20 μg/L). Recoveries, using the Waters Oasis cartridges performing extractions at pH 2, pH 4 and pH 7 proved to be the optimum at pH 4 (average recoveries (94.5%), except for cholesterol (10%), paracetamol (18%) and 2,5-dihydroxybenzoic acid (25%). Carbamazepine could be recovered at pH 7, only. Responses, obtained with derivatized standards proved to be linear in the range of 4–80 μg/L levels. Limit of quantitation values varied between 0.92 ng/L (4-hydroxyphenylacetic acid) and 600 ng/L (dehydrocholic acid) concentrations. One of the most important messages of this work is the confirmation of the origin of blank values. It was shown that contaminants, mainly 2,4-di-tert-butylphenol, different phthalates and fatty acids, are sourced both from the reagents and mainly from the SPE procedure, independent on the cartridge applied. Reproducibilities, characterized with the relative standard deviations (RSDs) of measurements, varied between 0.71% and 10%, with an average of 4.38% RSD. The practical utility of the method was shown by the identification and quantification of the pollutant contents of Hungarian influent and effluent wastewaters (for six consecutive months and that of the Danube River for 2 months). 相似文献
68.
Vibrationally highly excited molecules react extremely fast with atoms and probably with radicals. The phenomenon can be utilized for selectively enhancing the rate of reactions of specific bonds. On the basis of quasiclassical trajectory calculations, the paper analyzes mechanistic details of a prototype reaction, H + HF(v). At vibrational quantum numbers v above 2, the reaction exhibits capture-type behavior, that is, the reactive cross section diverges as the relative translational energy of the partners decreases, both for the abstraction and for the exchange channel. The mechanism of the reaction for both channels is different at low and at high translational energy. At low vibrational energy, the reaction is activated, which is switched to capture-type at high excitation. The reason is an attractive potential that acts on the attacking H atom when the HF molecule is stretched. In contrast to the 6-SEC potential surface of Mielke et al., the switch cannot be observed on the Stark-Werner potential surface, due to a small artificial barrier at high H-HF separation, preventing the reactants from obeying the attractive potential and also proving the importance of the latter. The exchange reaction can be observed even when the total energy available for the partners is below the exchange barrier, because at low translational energies the product F atom of a successful abstraction step can re-abstract that H atom from the intermediate product H2 molecule that was originally the attacker. 相似文献
69.
Camden JP Bechtel HA Ankeny Brown DJ Martin MR Zare RN Hu W Lendvay G Troya D Schatz GC 《Journal of the American Chemical Society》2005,127(34):11898-11899
A comparison between theory and experiment for the benchmark H + CD4 --> HD + CD3 abstraction reaction yields a reinterpretation of the reaction mechanism and highlights the unexpected contribution of a stripping mechanism. Whereas the best analytic surface fails to reproduce experiment, a first-principles direct-dynamics (on the fly) treatment is in good agreement, showing that the H + CD4 reaction exhibits extreme sensitivity to modest differences in the potential energy surface. We find that bent H-D-C transition state geometries play an important role in the dynamics. A simple model that relates the scattering angle impact parameter and cone of acceptance accounts well for the overall reaction dynamics. 相似文献
70.
Direct analysis in real time mass spectrometry (DART‐MS) of highly non‐polar low molecular weight polyisobutylenes 下载免费PDF全文
Lajos Nagy Tibor Nagy György Deák Ákos Kuki Borbála Antal Miklós Zsuga Sándor Kéki 《Journal of mass spectrometry : JMS》2015,50(9):1071-1078
Low molecular weight polyisobutylenes (PIB) with chlorine, olefin and succinic acid end‐groups were studied using direct analysis in real time mass spectrometry (DART‐MS). To facilitate the adduct ion formation under DART conditions, NH4Cl as an auxiliary reagent was deposited onto the PIB surface. It was found that chlorinated adduct ions of olefin and chlorine telechelic PIBs, i.e. [M + Cl]? up to m/z 1100, and the deprotonated polyisobutylene succinic acid [M? H]? were formed as observed in the negative ion mode. In the positive ion mode formation of [M + NH4]+, adduct ions were detected. In the tandem mass (MS/MS) spectra of [M + Cl]?, product ions were absent, suggesting a simple dissociation of the precursor [M + Cl]? into a Cl? ion and a neutral M without fragmentation of the PIB backbones. However, structurally important product ions were produced from the corresponding [M + NH4]+ ions, allowing us to obtain valuable information on the arm‐length distributions of the PIBs containing aromatic initiator moiety. In addition, a model was developed to interpret the oligomer distributions and the number average molecular weights observed in DART‐MS for PIBs and other polymers of low molecular weight. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献