排序方式: 共有27条查询结果,搜索用时 15 毫秒
21.
Dominicus Danardono Dwi Prija Tjahjana Zainal Arifin Suyitno Suyitno Wibawa Endra Juwana Aditya Rio Prabowo Catur Harsito 《力学快报》2021,11(3):100249
This study investigates the effect of Reynolds number on the performance of Savonius wind turbine with slotted blades. The turbine performance investigation was based on the torque coefficient( Ct), power coefficient( Cp), and tip speed ratio( TSR). The experiment used two number of blade configuration, blade overlap ratio of 10%, 12.5% and 20%, slotted position of 15%, 20%, 25% and 35%, and also slotted gap width of 3 mm, 5 mm, 7 mm, and 9 mm. The wind speed carried out in this experiment are 5.94 m/s, 6.46 m/s, 6.99 m/s, and 7.27 m/s, which are generated from the fan blowers as a wind source. The Savonius turbine with 10% overlap ratio shows the best performance. The highest Cp obtained is 0.138 by the variation of a 3 mm gap with Re of 1.44 × 10~4 and 0.526 TSR. 相似文献
22.
Putri Hawa Syaifie Azza Hanif Harisna Mochammad Arfin Fardiansyah Nasution Adzani Gaisani Arda Dwi Wahyu Nugroho Muhammad Miftah Jauhar Etik Mardliyati Nurwenda Novan Maulana Nurul Taufiqu Rochman Alfian Noviyanto Antonio J. Banegas-Luna Horacio Prez-Snchez 《Molecules (Basel, Switzerland)》2022,27(13)
Propolis contains a wide range of pharmacological activities because of their various bioactive compounds. The beneficial effect of propolis is interesting for treating type-2 diabetes mellitus (T2DM) owing to dysregulation of multiple metabolic processes. In this study, 275 of 658 Asian propolis compounds were evaluated as potential anti-T2DM agents using the DIA-DB web server towards 18 known anti-diabetes protein targets. More than 20% of all compounds could bind to more than five diabetes targets with high binding affinity (<−9.0 kcal/mol). Filtering with physicochemical and pharmacokinetic properties, including ADMET parameters, 12 compounds were identified as potential anti-T2DM with favorable ADMET properties. Six of those compounds, (2R)-7,4′-dihydroxy-5-methoxy-8-methylflavone; (RR)-(+)-3′-senecioylkhellactone; 2′,4′,6′-trihydroxy chalcone; alpinetin; pinobanksin-3-O-butyrate; and pinocembrin-5-methyl ether were first reported as anti-T2DM agents. We identified the significant T2DM targets of Asian propolis, namely retinol-binding protein-4 (RBP4) and aldose reductase (AKR1B1) that have important roles in insulin sensitivity and diabetes complication, respectively. Molecular dynamic simulations showed stable interaction of selected propolis compounds in the active site of RBP4 and AKR1B1. These findings suggest that Asian propolis compound may be effective for treatment of T2DM by targeting RBP4 and AKR1B1. 相似文献
23.
Trina Ekawati Tallei Fatimawali Ahmad Akroman Adam Mona M. Elseehy Ahmed M. El-Shehawi Eman A. Mahmoud Adinda Dwi Tania Nurdjannah Jane Niode Diah Kusumawaty Souvia Rahimah Yunus Effendi Rinaldi Idroes Ismail Celik Md. Jamal Hossain Talha Bin Emran 《Molecules (Basel, Switzerland)》2022,27(1)
Before entering the cell, the SARS-CoV-2 spike glycoprotein receptor-binding domain (RBD) binds to the human angiotensin-converting enzyme 2 (hACE2) receptor. Hence, this RBD is a critical target for the development of antiviral agents. Recent studies have discovered that SARS-CoV-2 variants with mutations in the RBD have spread globally. The purpose of this in silico study was to determine the potential of a fruit bromelain-derived peptide. DYGAVNEVK. to inhibit the entry of various SARS-CoV-2 variants into human cells by targeting the hACE binding site within the RBD. Molecular docking analysis revealed that DYGAVNEVK interacts with several critical RBD binding residues responsible for the adhesion of the RBD to hACE2. Moreover, 100 ns MD simulations revealed stable interactions between DYGAVNEVK and RBD variants derived from the trajectory of root-mean-square deviation (RMSD), radius of gyration (Rg), and root-mean-square fluctuation (RMSF) analysis, as well as free binding energy calculations. Overall, our computational results indicate that DYGAVNEVK warrants further investigation as a candidate for preventing SARS-CoV-2 due to its interaction with the RBD of SARS-CoV-2 variants. 相似文献
24.
Yuniawan Hidayat Niko Prasetyo Harno Dwi Pranowo 《International journal of quantum chemistry》2024,124(1):e27324
The dynamics and structure of Cs+ solvation in an aqueous ammonia solution have been investigated using the Quantum Mechanical Charge Field Molecular Dynamics (QMCF-MD) simulation method. The system contained 18.6% ammonia in aqueous solution at 298.15 K. The QM region was set to a radius of 7.0 Å to include the first and second solvation shells. The Hartree-Fock (HF) level was applied to calculate the ion-ligand and ligand–ligand interactions in the QM region using the LANL2DZ-ECP basis set for the ion and DZP-Dunning for the ligands. The radial distribution revealed only one solvation shell, indicating a labile solvation structure. The various coordination number of ligands suggests an instant exchange between them. The mean residence times of 1.29 and 0.9 ps were less than in the pure water and liquid ammonia system, indicating higher mobility ligands of the aqueous ammonia system. The preferential factor 0.55 supports the hypothesis that the Cs+ ion prefers to be dissolved in water. As the ligands moves further away from the ion, the observed number of hydrogen bonds increases, revealing the “structure-breaking” property of the Cs+ ion. The minimum angle ligand-ion-ligand tends to be higher near the ion, confirming this phenomenon. 相似文献
25.
Juniati Dwi; Trotman David; Valette Guillaume 《Journal London Mathematical Society》2003,68(1):133-147
The paper shows that, for subanalytic stratifications, Lipschitzequisingularity as defined by Mostowski is preserved after intersectionwith generic wings, that is, L-regularity implies L*-regularity.This was one of the conditions required of a good equisingularitynotion by Teissier in his foundational 1974 Arcata paper. Previous authors have shown that Lipschitz equisingularity isgeneric, implies bilipschitz triviality, and hence topologicaltriviality, and implies equimultiplicity. 相似文献
26.
Tutik Dwi Wahyuningsih 《Tetrahedron》2006,62(26):6343-6348
Treatment of the 2,4-dinitrophenyl ethers of some indole-7-ketoximes with base results in a cyclisation reaction to yield pyrrolo[3,2,1-hi]indazoles. 相似文献
27.
Holis Abdul Holik Faisal Maulana Ibrahim Angela Alysia Elaine Bernap Dwi Putra Arifudin Achmad Achmad Hussein Sundawa Kartamihardja 《Molecules (Basel, Switzerland)》2022,27(10)
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher. 相似文献