Analytical Quality-by-Design Approach for the Stability Study of Thiocolchicoside by Eco-Friendly Chromatographic Method

JPC – Journal of Planar Chromatography – Modern TLC - A robust and eco-friendly stability-indicating high-performance thin-layer chromatography (HPTLC) method was developed for the...     

An Exact Chameleon Cosmological Model Unifying Phantom Inflation with Late-Time Acceleration

An exact Chameleon cosmological model describing the evolution of a non-singular bouncing cosmology with the phantom divide line crossing is obtained by constructing two independent functions of the scalar field.     

Mesogenic cinnamates with a substituted ethyl terminal chain*

Two new mesogenic homologous series of liquid crystalline cinnamates with substituted ethyl tails, β‐methoxyethyl [4‐(4′‐n‐alkoxycinnamoyloxy)benzoates (I) and β‐chloroethyl [4‐(4′‐n‐alkoxycinnamoyloxy)benzoates (II), have been synthesized and characterized by a combination of elemental analysis and standard spectroscopic methods. In series I, lower‐chain members exhibit nematic mesophase, middle members exhibit enantiotropic nematic as well as smectic A (SmA) mesophases, whereas higher members exhibit only an enantiotropic SmA mesophase. In series II, methoxy to n‐butyloxy derivatives exhibit a monotropic nematic mesophase. The SmA mesophase commences from n‐propyloxy derivative as monotropic and persists up to the last member synthesized. The mesomorphic properties of present series were compared with each other and with a structurally related mesogenic homologous series to evaluate the effects of substituted ethyl tail and cinnamoyloxy central linkage on mesomorphism.     

Mesogenic quinazolone derivatives: synthesis and characterisation

Two new mesogenic homologous series of quinazolone derivatives have been synthesised by condensation of 4-n-alkoxybenzoyloxy benzaldehyde (for series I) / 4-n-alkoxy-3-methoxybenzoyloxy benzaldehyde (for series II) with 3-amino-2-methyl quinazolone in alcohol. The synthesised compounds are characterised by a combination of elemental analysis and standard spectroscopic methods. In series I, all the synthesised members exhibit the nematic mesophase. An enantiotropic smectic A phase is observed from the n-decyloxy derivative onward to the last homologue synthesised. Methoxy to n-propyloxy derivatives of series II are non-mesogenic, whereas the rest of the members exhibit a monotropic nematic mesophase. The mesomorphic properties of the present series I and II are compared with each other and with the other structurally related mesogenic homologous series to evaluate the effect of lateral methoxy substituent and quinazolone moiety on mesomorphism.     

Microwave-promoted efficient synthesis of spiroindenotetrahydropyridine derivatives via a catalyst- and solvent-free pseudo one-pot five-component tandem Knoevenagel/aza-Diels–Alder reaction

A microwave-assisted, one-pot pseudo five-component reaction strategy has been developed for the synthesis of some novel spiroindenotetrahydropyridine derivatives from 1,3-indanedione, an aromatic aldehyde, and ammonium acetate under catalyst- and solvent-free conditions via tandem Knoevenagel/aza-Diels–Alder reaction.     

Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions

Abstract  

Iodine catalyzes the pseudo four-component reaction of an aldehyde, a urea or thiourea, and cyclic 1,3-dicarbonyl compounds under microwave irradiation in a solvent-free condition to yield various σ symmetric spiro heterobicyclic rings in excellent yields.     

A Review on Polymeric-Based Phase Change Material for Thermo-Regulating Fabric Application

Abstract

Phase Changing Materials (PCM) portrays proficiency to liberate perceptible amount of latent heat on the course of phase transformation between liquid-solid or solid-liquid, thereby creating momentary warmth or cooling effect. PCM has been utilized in garments for introducing thermoregulating effect to diminish thermal discomfort of clothing. Assimilation of thermal energy by PCM causes delay in upsurge of microclimate temperature and results in substantial diminution of moisture release from skin thereby leading to inhibition of heat stress conditions and enhancement of thermo-physiological wearing comfort. Simultaneously, the insulating characteristic of such garment can also avert wearer from certain pivotal corollaries like hypothermia or heat syncope, keeping the individual in consolation owing to their automatic acclimatizing attribute in accordance with body and ecological temperature. As the assimilation of PCM into various textile materials have been extensively studied by researchers, an attempt has been made to explicate the recent existing literatures that have successfully integrated and implemented PCM in textile, concentrating on characteristics of PCMs integrated into fibers, and fabrics for potential industrial applications. Finally, various methodologies like coating, spinning & lamination being utilized for applying PCMs onto textiles for developing thermoregulated clothing have been discussed & concludes with challenges & future prospects.     

White analytical chemistry-driven stability-indicating concomitant chromatographic estimation of thiocolchicoside and aceclofenac using response surface analysis and red,green, and blue model

White analytical chemistry is a novel concept for the assessment of analytical methods on basis of its validation efficiency, greenness power, and economical efficiency. White analytical chemistry-driven stability indicating chromatographic method has been developed for the concomitant analysis of thiocolchicoside and aceclofenac. The proposed chromatographic method has been developed using a safe and environmental-friendly organic solvents for the concomitant stability study of thiocolchicoside and aceclofenac. The analytical risk assessment was carried out for the identification of high-risk analytical risk factors and analytical method performance attributes. The mixture design was applied for the design of experiments-based response surface modeling of high-risk analytical risk factors and analytical method performance attributes. The degradation products were isolated and characterized using infrared, nuclear magnetic resonance, and mass spectral data. The proposed method was compared for its validation efficiency, greenness power, and cost-efficiency with published chromatographic methods using the red, green, and blue models. The white score of the proposed and reported method was calculated by averaging the red, green, and blue scores of the methods. The proposed method was found to be robust, green, and economical for the concomitant stability study of thiocolchicoside and aceclofenac.