局部凸空间中ic -锥-类凸集值优化问题的超有效性

该文研究局部凸空间中受集值约束的集值优化问题的超有效解. 证明了ic -锥-类凸集值映射的一个有用性质, 并以此性质为主要工具, 得到了ic -锥-类凸集值向量优化问题超有效解的最优性条件和鞍点定理.     

Optimality for (<Emphasis Type="Italic">h,φ</Emphasis>)-multiobjective programming involving generalized type-I functions

Based upon Ben-Tal’s generalized algebraic operations, new classes of functions, namely (h,φ)-type-I, quasi (h,φ)-type-I, and pseudo (h,φ)-type-I, are defined for a multi-objective programming problem. Sufficient optimality conditions are obtained for a feasible solution to be a Pareto efficient solution for this problem. Some duality results are established by utilizing the above defined classes of functions, considering the concept of a Pareto efficient solution. This research is supported by National Science Foundation of China under Grant No. 69972036.     

建筑物对微波脉冲响应仿真与实验

 建立了微波脉冲在建筑物内传播、反射及透射过程的3维仿真模型,提取了空间电场时域最大值进行统计分析。分析表明：不同入射角窄带调制方波脉冲激励下,场增强区域大小与微波通过窗户和门能直接照射到的区域大小呈正比,窗户的大小对建筑物内空间场强增强区域的大小有显著影响;同时在微波脉冲的传播方向上,窗沿后的区域场强幅值明显减小;脉冲宽度对建筑物内空间场强增强区域的大小及空间场强最大值影响很小;无上升下降沿的窄带调制方波脉冲激励下,空间电场叠加增强效应更强。测量了微波脉冲辐照下,建筑物内空间功率密度分布,验证了仿真结果。     

胸苷激酶的免疫化学研究

采用免疫化学方法，以胸苷激酶（ＴＫ）抗体检测了５种培养的细胞（４种癌细胞和１种正常细胞）及１２种人类癌组织切片．结果表明，正常细胞呈阴性结果，４种癌细胞及１２种癌组织均呈阳性结果．提示此种方法在癌症的临床诊断方面可能有意义．     

现代加筋土技术应用与研究进展

对土工合成材料研究与应用概况、加筋土的国内外应用与研究进展、加筋土基本理论研究进展进行了综合分析,提出了今后研究工作的重点。     

分子工程学

分子工程学以体系的功能为导向,在分子水平上进行结构设计与施工,探索功能、结构与合成三者之间的关系原理,发展合成、制备与组装方法学,研究结构基元本征性质和构效关系。本文讨论了建设分子工程学这一新学科的重要性,介绍了自发单层分散原理与CO吸附剂、纳米结构光电功能体系、金属纳米簇基催化剂、表面分子多孔网络的精确可控组装以及功...     

Identification of [PtCl2(phen)] binding modes in amyloid-β peptide and the mechanism of aggregation inhibition

Platinum phenanthroline complexes inhibit amyloid-β (Aβ) aggregation and reduce Aβ-caused neurotoxicity [Proc. Natl. Acad. Sci., 2008, 105, 6813-6818]. In this study, we investigated the interactions of Aβ(1-16) with [PtCl(2)(phen)] (phen=1,10-phenanthroline) using HPLC, ESI-MS, and NMR spectroscopy , and characterized the identity of products using tandem mass spectrometry. Results indicated that the phenanthroline ligand could induce noncovalent interactions between Aβ peptide and platinum complexes, leading to rapid Aβ platination. Multiple products were generated in the reaction, in which His6/His14 chelation was preferentially formed. Coordination of Asp7, His13, and Lys16 was also detected in other products. The majority of products were monoplatinated adducts with binding of the {Pt(phen)} scaffold, which impeded intermolecular interactions between Aβ peptides. Moreover, noncovalent interactions were confirmed by the interaction between Aβ peptide and [Pt(phen)(2)]Cl(2). The synergistic roles of the phen ligand and platinum(II) atom in the inhibition of Aβ aggregation are discussed.     

Doubly hydrophilic multiarm hyperbranched polymers with acylhydrazone linkages as acid-sensitive drug carriers

A novel type of drug carrier capable of controlled drug release is proposed. It consists of an acid-sensitive doubly hydrophilic multiarm hyperbranched copolymer with a hyperbranched polyamidoamine core and many linear poly(ethylene glycol) arms. Using pH-sensitive acylhydrazone linkages, the polymer forms unimolecular micelles that can encapsulate hydrophobic drugs. Due to their amphiphilicity, the drug-loaded unimolecular micelles can self-assemble into multimolecular micelles that show acid-triggered intracellular delivery of the hydrophobic drugs.     

Total synthesis of (-)-cocaine and (-)-ferruginine

Total synthesis of tropane alkaloids (-)-cocaine and (-)-ferruginine were accomplished in nine steps each and in 55% and 46% overall yields, respectively, starting from the known Betti base derivative (+)-(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine. In this novel route, RCM reaction and 1,3-dipolar cycloaddition were employed as key steps for the enantioselective construction of tropane skeleton and the regioselective introduction of 3-bromo-2-isoxazoline ring as masked cis-2,3-disubstituents. To obtain the desired precursor (2S,5R)-2-allyl-5-vinylpyrrolidine for RCM reaction, we developed a general and practical method for the preparation of enantiopure cis-2,5-disubstituted pyrrolidines bearing alkene- and/or alkyne-containing substituents. We also offered two highly efficient pathways for the conversion of the 3-bromo-2-isoxazoline ring into the desired cis-2,3-disubstituted groups in (-)-cocaine and (-)-ferruginine.     

四磺基钴酞菁/MCM-41的制备、表征及其催化性能

将四磺基钴酞菁（CoTSPc）通过共价结合连接在氨基化的介孔分子筛MCM-41孔道壁上，制成负载酞菁催化剂，对其进行了X射线衍射（XRD）和红外分析，并研究了其对巯基乙醇的催化氧化反应动力学．结果表明，负载酞菁催化剂有优良的催化性能，在液相反应过程中扩散阻力较小．这种负载催化剂有酶催化特点，即遵循米氏动力学规律，米氏常数Km为0．015mol／L．反应完成后，通过沉淀即可从反应体系中分离，解决了酞菁催化剂无法回收利用和对环境造成新的污染的问题．在工业生产和环境保护方面有着良好应用前景．