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951.
Molecular motions in amorphous ibuprofen as studied by broadband dielectric spectroscopy 总被引:1,自引:0,他引:1
Brás AR Noronha JP Antunes AM Cardoso MM Schönhals A Affouard F Dionísio M Correia NT 《The journal of physical chemistry. B》2008,112(35):11087-11099
The molecular mobility of amorphous ibuprofen has been investigated by broadband dielectric relaxation spectroscopy (DRS) covering a temperature range of more than 200 K. Four different relaxation processes, labeled as alpha, beta, gamma, and D, were detected and characterized, and a complete relaxation map was given for the first time. The gamma-process has activation energy E a = 31 kJ.mol (-1), typical for local mobility. The weak beta-relaxation, observed in the glassy state as well as in the supercooled state was identified as the genuine Johari-Goldstein process. The temperature dependence of the relaxation time of the alpha-process (dynamic glass transition) does not obey a single VFTH law. Instead two VFTH regimes are observed separated by a crossover temperature, T B = 265 K. From the low temperature VFTH regime, a T g (diel) (tau =100 s) = 226 K was estimated, and a fragility or steepness index m = 93, was calculated showing that ibuprofen is a fragile glass former. The D-process has a Debye-like relaxation function but the temperature dependence of relaxation time also follows the VFTH behavior, with a Vogel temperature and a pre-exponential factor which seem to indicate that its dynamics is governed by the alpha-process. It has similar features as the Debye-type process observed in a variety of associating liquids, related to hydrogen bonding dynamics. The strong tendency of ibuprofen to form hydrogen bonded aggregates such as dimers and trimers either cyclic or linear which seems to control in particular the molecular mobility of ibuprofen was confirmed by IR spectroscopy, electrospray ionization mass spectrometry, and MD simulations. 相似文献
952.
Ezequiel F. V. Leitão Elizete Ventura Otávio L. de Santana Silmar A. do Monte 《International journal of quantum chemistry》2014,114(8):508-520
The unusual O‐coordination mode of nitrosamines to Fe(III) heme models has been observed in the bis(dimethylnitrosamine)(meso‐tetraphenylporphyrinate)iron(III) cation. For the first time, this latter as well as the simpler bis(dimethylnitrosamine)(porphinate)iron(III) heme model cations have been studied through ab initio methods. The sextet, quartet, and doublet spin states of both cations have been studied through single‐point calculations based on the experimental (X‐ray) geometry. Their energies, charges, and spin densities have been analyzed. The obtained results (at the UHF/cc‐pVDZ and ROHF/cc‐pVDZ levels) indicate that the peripheral benzene rings are of secondary importance for the coordination of dimethylnitrosamine to the Fe(III) porphyrin core. The obtained energy ordering is sextet < quartet < doublet, at all computational levels. The UHF, ROHF, and UMP2 results indicate an excess of alpha spin density around the Fe atom, a low covalency for the Fe? O bond and a substantial charge transfer to the Fe atom. Our best estimates [obtained at ROMP2 level with the mixed cc‐pVDZ/cc‐pVTZ‐DK(Fe) basis set] for the energy differences (in eV) between the three spin states considered are 0.929 for the sextet‐quartet gap and 0.812 for the quartet‐doublet gap, which indicate that the spin crossover (at room temperature) is very unlikely. These results represent the substantial decrease in the uncorrelated values. The implications of spin contaminations at the UHF and UMP2 levels for subsequent geometry optimizations to be performed in the smaller cation have also been discussed. © 2013 Wiley Periodicals, Inc. 相似文献
953.
Naiana G. P. B. Lima Igor P. B. Lima Denise M. C. Barros Thays S. Oliveira Fernanda N. Raffin Túlio F. A. de Lima e Moura Ana C. D. Medeiros Ana P. B. Gomes Cícero F. S. Aragão 《Journal of Thermal Analysis and Calorimetry》2014,115(3):2311-2318
Psoralens are widely used for the treatment of psoriasis. Trioxsalen is a drug prescribed low-dose, belonging to the group of substituted psoralen. The aim of this study was to evaluate the compatibility of trioxsalen with pharmaceutical excipients used in the solid forms by analytical techniques. Binary mixtures between the trioxsalen and pharmaceutical excipients (namely, magnesium stearate, α-lactose, microcrystalline cellulose 102, pregelatinized starch, mannitol, sodium lauryl sulfate, sodium starch glycolate, and croscarmellose sodium) were examined. The trioxsalen–sodium lauryl sulfate mixture displayed some physical interaction based on the DTA and DSC results, but the FTIR study ruled out any chemical change. 相似文献
954.
O. Frazão J.M. Marques J.L. Santos M.B. Marques J.M. Baptista 《Applied physics. B, Lasers and optics》2007,86(3):555-558
In this work, a Brillouin fibre laser sensor for strain and temperature discrimination is presented. The fibre laser sensor
consists of a Fabry–Pérot cavity with 20 m of optical fibre between two Bragg gratings. For the strain measurement, the 20 m
were split in half and in 10 m a pre-tension was applied originating two Brillouin peaks. For the temperature measurement
all of the sensing head was heated. The resolutions achieved were ±1 με and ±1 °C for strain and temperature measurements,
respectively.
PACS 42.81.-I; 42.55.Wd; 42.65.Es 相似文献
955.
I. L. Caldas R. L. Viana Z. O. Guimarães-Filho A. M. Batista S. R. Lopes F. A. Marcus M. Roberto K. C. Rosalem J. D. Szezech Jr. D. Toufen K. W. Gentle I. C. Nascimento Y. K. Kuznetsov 《Brazilian Journal of Physics》2014,44(6):903-913
Plasma turbulence at the edge of tokamaks is an issue of major importance in the study of the anomalous transport of particles and energy. Although the behavior of a turbulent plasma seems intractable, it turns out that many of its aspects can be described by low-dimensional non-integrable dynamical models. In this paper, we consider a number of dynamical effects occurring in tokamak plasma edge—in particular the role of internal transport barriers. Furthermore, we present experimental results on turbulent-driven transport for two machines—the Brazilian TCABR tokamak and University of Texas’ Helimak—that can be explained by those theoretical models. 相似文献
956.
Gizele Rejane Baldo Lucas Döhler Adelia Grzybowski Marcela Tiboni Lucas Blitzkow Scremin Heidegrid Siebert Koop Mábio João Santana Luciano Morais Lião José Domingos Fontana 《Cellulose (London, England)》2014,21(4):3041-3053
The removal of residual dyes in coloured textile wastewaters is mandatory, and a significant portion of the dyes used are cationic. Textile factories mainly process cotton yarns, and 8 % of this virgin feedstock is lost as cotton dust waste (CDW). Using factorial experimental design, this dust was derivatised with monochloroacetic acid (MCAA) to produce a partially carboxymethylated cellulose (CM?-CDW) with NaOH, MCAA and isopropanol for the retention of Basic Blue 41 dye (BB 41) (column and batch), and biodegradability was investigated. The dye retention efficiency was examined with additional experiments varying the initial concentration, contact time and addition of salts. Heteronuclear multiple bonding correlation-nuclear magnetic resonance confirmed the covalent insertion of CM? groups in the cellulosic fibres. The selected matrix provided a dye sorption of 58.33 (column) and 64.50 mg/g (batch). The Langmuir isotherm was a good fit to the sorption data. The efficiency of uptake of BB 41 was predominantly dictated by the concentration of alkali in the matrix synthesis. Biodegradability by cellulases was similar when using uncharged and dye-charged matrices. The latter were fully regenerated by washing in dilute acid. Retention was proportional to the initial dye concentration and the contact time required to reach equilibrium, which was longer for higher dye concentrations. The addition of 10 mmol/l NaCl decreased BB 41 retention by 50 %. Therefore, CM?-CDW proved effective for the removal of the cationic dye BB 41 and thus represents an important alternative in the treatment of coloured textile effluents. 相似文献
957.
Lima Thays Souza A. La-Scalea Mauro Raminelli Cristiano Simões Fábio R. Franco Edison da Silva Gabriela Dias Salvador Michele Aparecida Homem-de-Mello Paula de Oliveira Hueder P. M. Codognoto Lúcia 《Journal of Solid State Electrochemistry》2019,23(2):553-563
Journal of Solid State Electrochemistry - A simple, fast, and direct electroanalytical method has been developed for the pesticide chlorothalonil determination using a boron-doped diamond electrode... 相似文献
958.
Roberta de Oliveira Ramos Alice Battistin Reinaldo Sim?es Gon?alves 《Journal of Solid State Electrochemistry》2012,16(2):747-752
This paper presents experimental evidence of the ability of alcoholic Mentha extracts to inhibit the corrosion of low-carbon steel in aqueous acid solutions. Alcoholic extracts of Mentha spicata L., Mentha x gentilis L., Mentha crispa L., Mentha piperita L., and Mentha x piperita L. were tested. The corrosion inhibition capability of these extracts was confirmed by means of weight loss experiments,
cyclic voltammetry, chronoamperometry, polarization curves, and electrochemical impedance spectroscopy. 相似文献
959.
Luís M.N.B.F. Santos Luís M. Spencer S. Lima Carlos F.R.A.C. Lima Fernão D. Magalhães Manuel C. Torres Bernd Schröder Manuel A.V. Ribeiro da Silva 《The Journal of chemical thermodynamics》2011,43(6):834-843
A new Knudsen effusion apparatus, enabling simultaneous gravimetric and quartz crystal microbalance mass loss detection, is described. This device allows the measurement of vapour pressures of small sample mass (50 to 100) mg over a wide temperature range (350 to 650) K using very short effusion time intervals. The performance of the apparatus was checked by measuring the vapour pressures of anthracene, benzanthrone, and 1,3,5-triphenylbenzene, between (0.1 and 1) Pa, over temperature intervals of 20 K. The derived standard molar enthalpies of sublimation and vapour pressures are in excellent agreement with the mean of the available literature values and with the recommended values. The new working methodology and design of this apparatus allows the measurement of high quality vapour pressure data due to: accurate temperature measurement and control; improvement in vacuum thermal contact between the effusion cell and the oven metal block; optimisation of the quartz crystal sensor head microbalance position; efficient temperature control of the quartz crystal microbalance head; accurate measurement of the resonance crystal frequency using an impedance circuit analyser methodology. 相似文献
960.
Rapid and efficient method for the quantification of lychnopholide in rat plasma by liquid chromatography–tandem mass spectrometry for pharmacokinetic application 下载免费PDF全文
Larissa Lachi‐Silva João Paulo Barreto Sousa Maiara Camotti Montanha Sherwin K. B. Sy João Luis Callegari Lopes Denise Brentan Silva Norberto Peporine Lopes Andréa Diniz Elza Kimura 《Biomedical chromatography : BMC》2016,30(7):1092-1096
Lychnopholide is a sesquiterpene lactone usually obtained from Lychnophora and Eremanthus species and has pharmacological activities that include anti‐inflammatory and anti‐tumor. Lychnopholide isolated from Eremanthus matogrossenssis was analyzed in this study. The aims of this study were to develop and validate an analytical methodology by LC‐MS/MS and to quantify lychnopholide in rat plasma. Chromatographic separation was achieved on a C18 column using isocratic elution with the mobile phase consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.4 mL/min. The detection was performed in multiple‐reaction monitoring mode using electrospray ionization in positive mode. The method validation was performed in accordance with regulatory guidelines and the results met the acceptance criteria. The linear range of detection was 10–200 ng/mL (r > 0.9961). The intra‐ and inter‐day assay variability were <6.2 and <11.7%, respectively. The extraction recovery was approximately 63% using liquid–liquid extraction with chloroform. Lychnopholide was detected in plasma up to 60 min after intravenous administration in rats. This rapid and sensitive method for the analysis of the sesquiterpene lactone lychnopholide in rat plasma can be applied to pharmacokinetic studies of this compound. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献