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排序方式: 共有133条查询结果,搜索用时 15 毫秒
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Arturo Battaglia Andrea Guerrini Greta Varchi Ezio Bombardelli 《Tetrahedron letters》2006,47(16):2667-2670
Efficient syntheses of two taxol analogs bearing the linear polyamine spermine at 7- and 10-positions of paclitaxel and 10-deacetyl-paclitaxel have been developed. These polyamine-taxol-conjugates were isolated as water soluble difluoride salts. The aim of the present work was to introduce a chemical modification into taxol skeleton in order to increase drug selectivity toward tumor cells. The cytotoxic activity of these conjugates was evaluated in MCF7 and MCF7-R cell lines. The observed low cytotoxicity suggests that these conjugates could act as potential prodrugs. 相似文献
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Greta Wistbacka Pedro Amarante Andrade Susanna Simberg Britta Hammarberg Maria Södersten Jan G. Švec Svante Granqvist 《Journal of voice》2018,32(1):126.e11-126.e22
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The title compound was prepared from chloroacetic acid and elongated to dipeptides, which cyclized spontaneously upon Fmoc-deprotection to form N-allylated 2,5-diketopiperazines. 相似文献
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Musuc Adina Magdalena Patrinoiu Greta Budrugeac Petru Cucos Andrei Dascalu Radu Calderon-Moreno Jose Carp Oana 《Journal of Thermal Analysis and Calorimetry》2022,147(22):12805-12814
Journal of Thermal Analysis and Calorimetry - The combustion behavior of fructose-derived hydrochar was investigated using a kinetic evaluation protocol that brings about novel elements related to... 相似文献
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Marta Mameli M. Carla Aragoni Dr. Massimiliano Arca Dr. Claudia Caltagirone Dr. Francesco Demartin Prof. Giovanna Farruggia Dr. Greta De Filippo Francesco A. Devillanova Prof. Alessandra Garau Dr. Francesco Isaia Prof. Vito Lippolis Prof. Dr. Sergio Murgia Dr. Luca Prodi Prof. Dr. Anna Pintus Nelsi Zaccheroni Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(3):919-930
In spite of the fact that cadmium(II) has been recognized as a highly toxic element and that excessive exposure to this metal ion has been reported to have many adverse effects on human health, very few selective and specific fluorescent probes are available for imaging Cd2+ in living cells. Herein, we report the spectroscopic and photochemical characterization of 5‐(5‐chloro‐8‐hydroxyquinolinylmethyl)‐2,8‐dithia‐5‐aza‐2,6‐pyridinophane ( L ) as a fluorescent sensor for the selective imaging of Cd2+ in living cells. In particular, the response of L to Cd2+ was first assessed in aqueous solutions, sodium dodecyl sulfate micelles, and liposomes, and subsequently in living cells by fluorescence microscopy techniques. Cytofluorimetric analyses of leukemic HL‐60 cells loaded with L also allowed evaluation of the toxicity of the probe and the selective analysis of its intracellular fluorescence in the presence of Cd2+. Furthermore, the 1:1 complex species [Cd( L )H2O]2+ responsible for the OFF–ON chelation enhancement of fluorescence (CHEF) effect on L was structurally characterized; time‐dependent DFT calculations allowed the prediction of theoretical excitations, which were comparable with the experimental ones. 相似文献
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