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31.
An efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl thioethers using potassium ethyl xanthogenate as a thiol surrogate is developed. This new protocol avoids usage of intricate thiols and makes use of its easily available xanthate as a precursor, and thiol will be generated in situ to prepare the diaryl thioethers through a Cu-catalyzed double arylation. This strategy was further successfully utilized for the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles. 相似文献
32.
The hydrolysis of β-lactam antibiotics using zinc-containing metallo-β-lactamases (mβl) is one of the major bacterial defense systems. These enzymes can catalyze the hydrolysis of a variety of antibiotics including the latest generation of cephalosporins, cephamycins, and imipenem. It is shown in this paper that the cephalosporins having heterocyclic -SR side chains are less prone to mβl-mediated hydrolysis than the antibiotics that do not have such side chains. This is partly due to the inhibition of enzyme activity by the thione moieties eliminated during hydrolysis. When the enzymatic hydrolysis of oxacillin was carried out in the presence of heterocyclic thiones such as MTT, MDT, DMETT, and MMA, the catalytic activity of the enzyme was inhibited significantly by these compounds. Although the heterocyclic -SR moieties eliminated from the β-lactams upon hydrolysis undergo a rapid tautomerism between thione and thiol forms, these compounds act as thiolate ligands toward zinc(II) ions. The structural characterization of two model tetranuclear zinc(II) thiolate complexes indicates that the -SR side chains eliminated from the antibiotics may interact with the zinc(II) metal center of mβl through their sulfur atoms. 相似文献
33.
Park K Engelkemier J Persico M Manikandan P Hase WL 《The journal of physical chemistry. A》2011,115(24):6603-6609
Algorithms are presented for sampling quantum microcanonical ensembles for a potential energy minimum and for the conical intersection at the minimum energy crossing point of two coupled electronic states. These ensembles may be used to initialize trajectories for chemical dynamics simulations. The unimolecular dynamics of a microcanonical ensemble about a potential energy minimum may be compared with the dynamics predicted by quantum Rice-Ramsperger-Kassel-Marcus (RRKM) theory. If the dynamics is non-RRKM, it will be of particular interest to determine which states have particularly long lifetimes. Initializing a microcanonical ensemble for the electronically excited state at a conical intersection is a model for electronic nonadiabatic dynamics. The trajectory surface-hopping approach may be used to study the ensuing chemical dynamics. A strength of the model is that zero-point energy conditions are included for the initial nonadiabatic dynamics at the conical intersection. 相似文献
34.
We employed primer extension reactions to uncover folding motifs in a nuclease hypersensitive element (NHE) with a complex guanine pattern, located in the human KRAS promoter. We also identified and characterized a new G-rich motif of 21 nt capable of forming a parallel G-quadruplex that is disrupted by protein UP1. 相似文献
35.
Manikandan R Viswanathamurthi P Muthukumar M 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2011,83(1):297-303
Ruthenium(II) hydrazone Schiff base complexes of the type [RuCl(CO)(B)(L)] (were B=PPh(3), AsPh(3) or Py; L=hydrazone Schiff base ligands) were synthesized from the reactions of hydrazone Schiff base ligand (obtained from isonicotinoylhydrazide and different hydroxy aldehydes) with [RuHCl(CO)(EPh(3))(2)(B)] (where E=P or As; B=PPh(3), AsPh(3) or Py) in 1:1 molar ratio. All the new complexes have been characterized by analytical and spectral (FT-IR, electronic, (1)H, (13)C and (31)P NMR) data. They have been tentatively assigned an octahedral structure. The synthesized complexes have exhibited catalytic activity for oxidation of benzyl alcohol to benzaldehyde and cyclohexanol to cyclohexanone in the presence of N-methyl morpholine N-oxide (NMO) as co-oxidant. They were also found to catalyze the transfer hydrogenation of aliphatic and aromatic ketones to alcohols in KOH/Isopropanol. 相似文献
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Some novel compounds of bis/mono 1-aryl-1H-tetrazole-5-carboxylic acid are synthesized by the hydrolysis of two different synthesized esters, they are ethyl-1-aryl-1H-tetrazole-5-carboxylate and ethyloxo(1-aryl-1H-tetrazol-5-yl)acetate. The ethyl-1-aryl-1H-tetrazole-5-carboxylate is resistant to get hydrolyzed, whereas the ethyloxo(1-aryl-1H-tetrazol-5-yl) acetate undergoes hydrolysis process and converts the ester to title compound. All the synthesized compounds are characterized by IR, 1H and 13C NMR, mass and elemental analysis.The ethyl-1-aryl-1H-tetrazole-5-carboxylateis optimized by DFT B3LYP method and the HOMO and LUMO energy is 5.14?eV and also there is a formation of a weak bond between O18 and C8 as observed from the AIM analysis result. 相似文献
40.
Govindasamy Chandrasekar 《Journal of Non》2008,354(33):4027-4030
A supernatant solution of silicate species extracted from coal fly ash in a power plant by alkali fusion was used under acidic conditions to prepare a mesoporous silica, SBA-16. SBA-16 was used as a template for the synthesis of a mesoporous carbon using sucrose as a carbon source. These mesoporous silica and carbon materials were characterized by XRD, N2 adsorption-desorption, SEM, and TEM. Textural properties of the silica and carbon samples prepared using fly ash were found to be comparable to those prepared by pure chemicals, successfully demonstrating the feasibility of recycling fly ash for the synthesis of high quality porous materials. 相似文献