全文获取类型
收费全文 | 263篇 |
免费 | 2篇 |
专业分类
化学 | 124篇 |
晶体学 | 1篇 |
力学 | 2篇 |
数学 | 14篇 |
物理学 | 124篇 |
出版年
2022年 | 2篇 |
2018年 | 2篇 |
2016年 | 2篇 |
2014年 | 7篇 |
2013年 | 13篇 |
2012年 | 13篇 |
2011年 | 15篇 |
2010年 | 10篇 |
2009年 | 6篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 7篇 |
2005年 | 12篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 8篇 |
2001年 | 3篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1991年 | 3篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 13篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1966年 | 4篇 |
1964年 | 2篇 |
1938年 | 2篇 |
1936年 | 3篇 |
1927年 | 1篇 |
1907年 | 1篇 |
1906年 | 1篇 |
1891年 | 1篇 |
1890年 | 1篇 |
1880年 | 2篇 |
1870年 | 1篇 |
1863年 | 1篇 |
排序方式: 共有265条查询结果,搜索用时 15 毫秒
261.
P. Ravi Girish M. Gore Arun K. Sikder Surya P. Tewari 《International journal of quantum chemistry》2012,112(6):1667-1677
Density functional theory (DFT) calculations at the B3LYP/aug‐cc‐pVDZ level have been carried out to study the geometry and electronic structures, stability, sensitivity and band gap of the possible isomers of aminonitropyrazole‐2‐oxides. Kamlet‐Jacob equations were used to determine the performance properties of model compounds. The performance properties of model compounds P5, P18, P20, P21, P22, and P23 are higher compared with 2,4,6,8,10,12‐hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane (CL‐20) and octanitrocubane (ONC). The heat of explosion, density, detonation velocity and detonation pressure are related to the number and positions of NO2 and NH2 groups in pyrazole‐2‐oxide. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012 相似文献
262.
Different methods of assessing human brain function possess specific advantages and disadvantages compared to others, but it is believed that combining different approaches will provide greater information than can be obtained from each alone. For example, functional magnetic resonance imaging (fMRI) has good spatial resolution but poor temporal resolution, whereas the converse is true for electrophysiological recordings (event-related potentials or ERPs). In this review of recent work, we highlight a novel approach to combining these modalities in a manner designed to increase information on the origins and locations of the generators of specific ERPs and the relationship between fMRI and ERP signals. Near infrared imaging techniques have also been studied as alternatives to fMRI and can be readily integrated with simultaneous electrophysiological recordings. Each of these modalities may in principle be also used in so-called steady-state acquisitions in which the correlational structure of signals from the brain may be analyzed to provide new insights into brain function. 相似文献
263.
Moore J Jankiewicz M Anderson AW Gore JC 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2012,214(1):212-220
There is a continuing need for improved RF pulses that achieve proper refocusing in the context of ultra-high field (≥ 7 T) human MRI. Simple block or sinc pulses are highly susceptible to RF field inhomogeneities, and adiabatic pulses are generally considered too SAR intensive for practical use at 7 T. The performance of the array of pulses falling between these extremes, however, has not been systematically evaluated. The aim of this work was to compare the performances of 21 non-selective refocusing pulses spanning a range of durations and SAR levels. The evaluation was based upon simulations and both phantom and in vivo human brain experiments conducted at 7 T. Tested refocusing designs included block, composite block, BIR-4, hyperbolic secant, and numerically optimized composite waveforms. These pulses were divided into three SAR classes and two duration categories, and, based on signal gain in a 3-D spin echo sequence, practical recommendations on usage are made within each category. All evaluated pulses were found to produce greater volume-averaged signals relative to a 180° block pulse. Although signal gains often come with the price of increased SAR or duration, some pulses were found to result in significant signal enhancement while also adhering to practical constraints. This work demonstrates the signal gains and losses realizable with single-channel refocusing pulse designs and should assist in the selection of suitable refocusing pulses for practical 3-D spin-echo imaging at 7 T. It further establishes a reference against which future pulses and multi-channel designs can be compared. 相似文献
264.
Christian Steinmetzger Navaneethan Palanisamy Dr. Kiran R. Gore Prof. Dr. Claudia Höbartner 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(8):1931-1935
Large Stokes shift (LSS) fluorescent proteins (FPs) exploit excited state proton transfer pathways to enable fluorescence emission from the phenolate intermediate of their internal 4-hydroxybenzylidene imidazolone (HBI) chromophore. An RNA aptamer named Chili mimics LSS FPs by inducing highly Stokes-shifted emission from several new green and red HBI analogues that are non-fluorescent when free in solution. The ligands are bound by the RNA in their protonated phenol form and feature a cationic aromatic side chain for increased RNA affinity and reduced magnesium dependence. In combination with oxidative functionalization at the C2 position of the imidazolone, this strategy yielded DMHBO+, which binds to the Chili aptamer with a low-nanomolar KD. Because of its highly red-shifted fluorescence emission at 592 nm, the Chili–DMHBO+ complex is an ideal fluorescence donor for Förster resonance energy transfer (FRET) to the rhodamine dye Atto 590 and will therefore find applications in FRET-based analytical RNA systems. 相似文献
265.
Gore KR Nawale GN Harikrishna S Chittoor VG Pandey SK Höbartner C Patankar S Pradeepkumar PI 《The Journal of organic chemistry》2012,77(7):3233-3245
The linear syntheses of 4'-C-aminomethyl-2'-O-methyl uridine and cytidine nucleoside phosphoramidites were achieved using glucose as the starting material. The modified RNA building blocks were incorporated into small interfering RNAs (siRNAs) by employing solid phase RNA synthesis. Thermal melting studies showed that the modified siRNA duplexes exhibited slightly lower T(m) (~1 °C/modification) compared to the unmodified duplex. Molecular dynamics simulations revealed that the 4'-C-aminomethyl-2'-O-methyl modified nucleotides adopt South-type conformation in a siRNA duplex, thereby altering the stacking and hydrogen-bonding interactions. These modified siRNAs were also evaluated for their gene silencing efficiency in HeLa cells using a luciferase-based reporter assay. The results indicate that the modifications are well tolerated in various positions of the passenger strand and at the 3' end of the guide strand but are less tolerated in the seed region of the guide strand. The modified siRNAs exhibited prolonged stability in human serum compared to unmodified siRNA. This work has implications for the use of 4'-C-aminomethyl-2'-O-methyl modified nucleotides to overcome some of the challenges associated with the therapeutic utilities of siRNAs. 相似文献