排序方式: 共有119条查询结果,搜索用时 203 毫秒
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Gokhan Zengin María de la Luz Cdiz-Gurrea lvaro Fernndez-Ochoa Francisco Javier Leyva-Jimnez Antonio Segura Carretero Malwina Momotko Evren Yildiztugay Refik Karatas Sharmeen Jugreet Mohamad Fawzi Mahomoodally Grzegorz Boczkaj 《Molecules (Basel, Switzerland)》2022,27(18)
In the present study, the extracts of Cytinus hypocistis (L.) L using both traditional solvents (hexane, ethyl acetate, dichloromethane, ethanol, ethanol/water, and water) and natural deep eutectic solvents (NADESs) were investigated in terms of their total polyphenolic contents and antioxidant and enzyme-inhibitive properties. The extracts were found to possess total phenolic and total flavonoid contents in the ranges of 26.47–186.13 mg GAE/g and 0.68–12.55 mg RE/g, respectively. Higher total phenolic contents were obtained for NADES extracts. Compositional differences were reported in relation to antioxidant potential studied by several assays (DPPH: 70.19–939.35 mg TE/g, ABTS: 172.56–4026.50 mg TE/g; CUPRAC: 97.41–1730.38 mg TE/g, FRAP: 84.11–1534.85 mg TE/g). Application of NADESs (choline chloride—urea 1:2, a so-called Reline) allowed one to obtain the highest number of extracts having antioxidant potential in the radical scavenging and reducing assays. NADES-B (protonated by HCl L-proline-xylitol 5:1) was the only extractant from the studied solvents that isolated a specific fraction without chelating activity. Reline extract exhibited the highest acetylcholinesterase inhibition compared to NADES-B and NADES-C (protonated by H2SO4 L-proline-xylitol 5:1) extracts, which showed no inhibition. The NADES extracts were observed to have higher tyrosinase inhibitory properties compared to extracts obtained by traditional organic solvents. Furthermore, the NADES extracts were relatively better inhibitors of the diabetic enzymes. These findings provided an interesting comparison in terms of total polyphenolic content yields, antioxidant and enzyme inhibitory properties (cholinesterase, amylase, glucosidase, and tyrosinase) between traditional solvent extracts and NADES extracts, used as an alternative. While the organic solvents showed better antioxidant activity, the NADES extracts were found to have some other improved properties, such as higher total phenolic content and enzyme-inhibiting properties, suggesting functional prospects for their use in phytonutrient extraction and fractionation. The obtained results could also be used to give a broad overview of the different biological potentials of C. hypocistis. 相似文献
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Lucia Recinella Annalisa Chiavaroli Viviana di Giacomo Marco Daniel Antolini Alessandra Acquaviva Sheila Leone Luigi Brunetti Luigi Menghini Gunes Ak Gokhan Zengin Simonetta Cristina Di Simone Claudio Ferrante Giustino Orlando 《Molecules (Basel, Switzerland)》2021,26(1)
Tanacetum parthenium (feverfew) has traditionally been employed as a phytotherapeutic remedy in the treatment of migraine. In this study, a commercial T. parthenium water extract was investigated to explore its anti-inflammatory and neuromodulatory effects. Isolated mouse cortexes were exposed to a K+ 60 mM Krebs-Ringer buffer and treated with T. parthenium water extract. The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. The effects on dopamine (DA) release and dopamine transporter (DAT) gene expression were assayed in hypothalamic HypoE22 cells. A bioinformatics analysis was conducted to further investigate the mechanism of action. The extract was effective in reducing cortex PGE2 release and IL-1β gene expression. In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. Overall, the present findings highlight the efficacy of T. parthenium water extract in controlling the inflammatory pathways that occur during cortical-spreading depression. Additionally, the inhibition of the hypothalamic DA release observed in this study further supports the role of dopaminergic pathways as key targets for novel pharmacological approaches in the management of migraine attacks. 相似文献
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Erhan Cengiz Zekeriya Biyiklioglu Nuray Kup Aylikci Volkan Aylikci Gokhan Apaydin Engin Tirasglu Halit Kantekin 《化学物理学报》2010,23(2):138-144
对钴、镍、铜、锌元素组成的不同配合物K壳层X射线的产生截面、谱线强度比、俄歇辐射强度比进行了测定,同时研究了化学效应对K壳荧光参数和俄歇辐射强度比的影响,并根据电荷转移过程解释了这些参数的变化. 采用59.5 keV的γ射线241Am的环形放射源对样品进行激发. 用分辨率为150eV的Ultra-LEGe探测器在5.9 keV测定样品产生的K壳X射线. 相似文献
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Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation 总被引:1,自引:0,他引:1
Tim R Mercer Irfan A Qureshi Solen Gokhan Marcel E Dinger Guangyu Li John S Mattick Mark F Mehler 《BMC neuroscience》2010,11(1):14
Background
Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain. 相似文献76.
In this work, density functional theory calculations on the structural, mechanical, and lattice dynamical properties of Re2C within ReB2‐type structure are reported. The generalized gradient approximation has been used for modeling exchange–correlation effects. We have predicted the lattice constants, bulk modulus, bond distances, elastic constants, shear modulus, Young's modulus, Poisson's ratio, hardness, Debye temperature, and sound velocities of this compound. Furthermore, the band structure, phonon dispersion curves and corresponding density of states are computed. The obtained results are in good agreement with the available experimental and other theoretical data. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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Microchimica Acta - Coliform bacteria physically immobilized on titanium dioxide nanoparticles can be used as a biosorbent for solid phase extraction of lead (II) ions from aqueous solution using a... 相似文献
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