Self‐assembly of di‐ and triblock PEG‐pentavaline amphiphiles

Nanoparticles formed from amphiphilic block copolymers can be used as drug delivery vehicles for hydrophilic therapeutics. Poly(ethylene glycol) (PEG)‐peptide copolymers were investigated for their self‐assembling properties and as consequent potential delivery systems. Mono‐ and dihydroxy PEGs were functionalized with a pentavaline sequence bearing Fmoc end groups. The molecular weight of the PEG component was varied to evaluate copolymer size and block number. These di‐ and tri‐block copolymers readily self‐assemble in aqueous solution with critical aggregation concentrations (CACs) of 0.46–16.29 μM. At concentrations above the CAC, copolymer solutions form spherical assemblies. Dynamic light scattering studies indicate these aggregates have a broad size distribution, with average diameters between 33 and 127 nm. The copolymers are comprised β‐conformations that are stable up to 80 °C, as observed by circular dichroism. This peptide secondary structure is retained in solutions up to 50% MeOH as well. The triblock copolymers proved to be the most stable, with copolymers synthesized from 10 kDa PEG having the most stable particles. Loading of carboxyfluorescein at 2–5 mol % shows that these copolymers have the potential to encapsulate hydrophilic drugs for delivery applications. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011     

Assessment of Areal (Three-Dimensional) Roughness Parameters of Milled Surface Using Charge-Coupled Device Flatbed Scanner and Image Processing

Experimental Techniques - A new application of the charge-coupled device (CCD) flatbed scanner for the noncontact assessment of areal three-dimensional (3D) roughness parameters of milled surfaces...     

Large deformation extensional rheology of bread dough

The stress–strain curves of bread dough were derived under uniaxial compression, uniaxial tension and equi-biaxial tension loading conditions. In uniaxial compression, a lubricant was used to eliminate frictional effects between the loading platens and the sample. In uniaxial tension, cylindrical samples with thin flat discs at both ends (‘I’ samples) were tested. The discs at both ends were allowed to air-dry and were subsequently glued onto the loading platens. In equi-biaxial tension, a thin disc of dough was inflated into a bubble using pressurised air. The thickness at the top of the bubble was measured by shining a light through the walls of the bubble and recording the change in light intensity as the wall becomes thinner. All methods ensured that uniform deformation was obtained. Stress and strain were accurately evaluated using image analysis techniques. The tests were performed at various strain rates and speeds that defined the time dependence of the material. A non-linear viscoelastic model based on the Prony series and Van der Waals hyperelasticity was used to predict all test data. The model had a total of five material parameters and two time constants, which were set to represent the actual time scales of the experiments. A reasonable agreement between the experimental data and the chosen material model was observed.     

A structured solution framework for fuzzy minimum spanning tree problem and its variants under different criteria

This paper develops a unified and structured solution framework for the minimum spanning tree (MST) problem and its variants (e.g., constrained MST problem and inverse MST problem) on networks with fuzzy link weights. It is applicable to any additive decision criterion under fuzziness (e.g., expected value, value at risk, and conditional value at risk), for generalized cases that the link weights may be represented by arbitrary types of fuzzy variables. It also applies to the entropy criterion while the link weights are continuous fuzzy variables. Following the optimality conditions of the fuzzy MST under different decision criteria proved first in this paper, it is shown that the MST problem and its variants on a fuzzy network can be converted into equivalent deterministic counterparts on their corresponding crisp networks. Consequently, these problems can be effectively solved via their deterministic counterparts without fuzzy simulation, and meanwhile, the performance of the trees under a specified criterion is precisely measured. The accuracy and efficiency are both significantly improved compared with other fuzzy simulation-based approaches. Numerical examples illustrate the superiority of the proposed solution framework. Furthermore, some new theoretical conclusions on the MST problem under fuzziness are also presented.

     

Observation of D+ → K(+)η(') and search for CP violation in D+ → π(+)η(') decays

We report the first observation of the doubly Cabibbo-suppressed decays D(+)→K(+)η((')) using a 791 fb(-1) data sample collected with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. The ratio of the branching fractions of doubly Cabibbo-suppressed relative to singly Cabibbo-suppressed D(+)→π(+)η((')) decays are B(D(+)→K(+)η)/B(D(+)→π(+)η)=(3.06±0.43±0.14)% and B(D(+)→K(+)η')/B(D(+)→π(+)η')=(3.77±0.39±0.10)%. From these, we find that the relative final-state phase difference between the tree and annihilation amplitudes in D(+) decays, δ(TA), is (72±9)° or (288±9)°. We also report the most precise measurements of CP asymmetries to date: A(CP)(D(+)→π(+)η)=(+1.74±1.13±0.19)% and A(CP)(D(+)→π(+)η')=(-0.12±1.12±0.17)%.     

Stereospecific Cyclic Poly(methyl methacrylate) and Its Topology‐Guided Hierarchically Controlled Supramolecular Assemblies

In this study, the stereocomplexation between a novel stereospecific cyclic vinyl polymer, that is, cyclic syndiotactic poly(methyl methacrylate) (st‐PMMA), with the complementary linear isotactic (it‐) PMMA was investigated. Surprising new insight into the effects of the topology (i.e., end groups), size, and tacticity of the assembling components on stereocomplex formation was obtained. Characterization of the stereocomplexes revealed that the self‐assembly of cyclic st‐PMMAs and linear it‐PMMAs resulted in the formation of an unprecedented “polypseudorotaxane‐type” supramolecular assembly. This stereocomplex exhibited remarkably different physical properties as compared to the conventional PMMA triple‐helix stereocomplex as a result of the restricted topology imposed by the cyclic st‐PMMA assembling component.