Cryogenics and Einstein Telescope

The dominant noises which limit the present sensitivity of the gravitational wave detectors are the thermal noise of the suspended mirrors and the shot noise. For the third generation of gravitational wave detectors as the Einstein Telescope (ET), the reduction of the shot noise implies to increase the power stored in the detector at 1 MW level and, at the same time, to compensate the huge optic distortion due to induced thermal lensing. At low temperature it is possible to reduce both these effects. However, lowering the temperature of the test masses without injecting vibration noise from the cooling system is a technological challenge. We review here the thermal noise impact on the ultimate ET sensitivity limit and we discuss possible cryogenic configurations to cool the mirror.     

CHIRAL VARIANTS OF ARYLALKYL SULFUR REAGENTS. (R)-CAMPHOR KETIMINES OF OGIOVANNA AMINOTHIOETHERS AND OXIDES

Abstract

Ketimines la-d derived from ortho-aminosubstituted phenylthioethers were prepared in order to determine the degree of chirality transfer from the chiral auxiliary to the sulfur atom in the formation of the sulfoxide or to the α-carbon atom in the reaction of the anion with alkyl halides or benzaldehyde. Oxidation to the sulfoxide occurred with little or no asymmetric induction. The crystalline benzyl sulfone 4c was deprotonated by alkyllithium or Grignard reagents and reacted with alkyl halides and benzaldehyde, in all cases with little to fair transfer of chirality. The major diastereoisomer from methylation of the anion of 4c with methyl iodide, was isolated, and afforded the enantiomerically pure amine 5 after removal of the chiral auxiliary. An X-ray structure determination of 4d allowed the assignment of the absolute configuration of the asymmetric carbon and revealed that the conformation of the ketimine in the crystal state is not homogeneous.     

In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands

The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this work, a virtual screening workflow of a library consisting of ~6 million molecules was set up, with the aim to find potential lead compounds that could manifest activity on the KOR. This in silico study provides a significant contribution in the identification of compounds capable of interacting with a specific molecular target. The main computational techniques adopted in this experimental work include: (i) virtual screening; (ii) drug design and leads optimization; (iii) molecular dynamics. The best hits are tripeptides prepared via solution phase peptide synthesis. These were tested in vivo, revealing a good antinociceptive effect after subcutaneous administration. However, further work is due to delineate their full pharmacological profile, in order to verify the features predicted by the in silico outcomes.     

Metal complex derivatives of bis(pyrazol-1-yl)methane ligands: synthesis,characterization and anti-Trypanosoma cruzi activity

Transition Metal Chemistry - In this work, the synthesis and characterization of seven complexes (1–7) was performed with Zn(II), Cu(II), Co(II) and Ni(II) transition metals and ligands...     

A Priori Tests of RANS Models for Turbulent Channel Flows of a Dense Gas

Dense gas effects, encountered in many engineering applications, lead to unconventional variations of the thermodynamic and transport properties in the supersonic flow regime, which in turn are responsible for considerable modifications of turbulent flow behavior with respect to perfect gases. The most striking differences for wall-bounded turbulence are the decoupling of dynamic and thermal effects for gases with high specific heats, the liquid-like behavior of the viscosity and thermal conductivity, which tend to decrease away from the wall, and the increase of density fluctuations in the near wall region. The present work represents a first attempt of quantifying the influence of such dense gas effects on modeling assumptions employed for the closure of the Reynolds-averaged Navier–Stokes equations, with focus on the eddy viscosity and turbulent Prandtl number models. For that purpose, we use recent direct numerical simulation results for supersonic turbulent channel flows of PP11 (a heavy fluorocarbon representative of dense gases) at various bulk Mach and Reynolds numbers to carry out a priori tests of the validity of some currently-used models for the turbulent stresses and heat flux. More specifically, we examine the behavior of the modeled eddy viscosity for some low-Reynolds variants of the \(k-\varepsilon \) model and compare the results with those found for a perfect gas at similar conditions. We also investigate the behavior of the turbulent Prandtl number in dense gas flow and compare the results with the predictions of two well-established turbulent Prandtl number models.     

Fractional visco-elastic Euler–Bernoulli beam

Aim of this paper is the response evaluation of fractional visco-elastic Euler–Bernoulli beam under quasi-static and dynamic loads. Starting from the local fractional visco-elastic relationship between axial stress and axial strain, it is shown that bending moment, curvature, shear, and the gradient of curvature involve fractional operators. Solution of particular example problems are studied in detail providing a correct position of mechanical boundary conditions. Moreover, it is shown that, for homogeneous beam both correspondence principles also hold in the case of Euler–Bernoulli beam with fractional constitutive law. Virtual work principle is also derived and applied to some case studies.     

Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

Tacle^® is a citrus fruit obtained from the crossbreeding of Clementine and Tarocco cultivars. This fruit retains a promising nutraceutical potential most likely due to a high content in polyphenols, among which the main constituents are the two glycosides naringin and hesperidin. Herein, we evaluated, through an in vitro assay, the capability of Tacle extracts to inhibit the hydroxymethylglutaryl-CoA reductase enzyme, which plays a key role in cholesterol biosynthesis. The results obtained spurred us to investigate whether the anti-enzymatic activity observed may be due to a direct interaction of aglycones naringenin and hesperetin with the enzyme catalytic site. Molecular docking simulations indicated that these two compounds are able to anchor to the protein with binding modes and affinities similar to those found for statins, which represent mainstream medications against hypercholesterolemia. The overall results showed an interesting nutraceutical potential of Tacle, suggesting that its extract could be used for dietary supplementation in the treatment of moderate hypercholesterolemia.     

Synthesis,Characterization, and Optimization Studies of Starch/Chicken Gelatin Composites for Food-Packaging Applications

The indiscriminate use of plastic in food packaging contributes significantly to environmental pollution, promoting the search for more eco-friendly alternatives for the food industry. This work studied five formulations (T1–T5) of biodegradable cassava starch/gelatin films. The results showed the presence of the starch/gelatin functional groups by FT-IR spectroscopy. Differential scanning calorimetry (DSC) showed a thermal reinforcement after increasing the amount of gelatin in the formulations, which increased the crystallization temperature (Tc) from 190 °C for the starch-only film (T1) to 206 °C for the film with 50/50 starch/gelatin (T3). It also exhibited a homogeneous surface morphology, as evidenced by scanning electron microscopy (SEM). However, an excess of gelatin showed low compatibility with starch in the 25/75 starch/gelatin film (T4), evidenced by the low Tc definition and very rough and fractured surface morphology. Increasing gelatin ratio also significantly increased the strain (from 2.9 ± 0.5% for T1 to 285.1 ± 10.0% for T5) while decreasing the tensile strength (from 14.6 ± 0.5 MPa for T1 to 1.5 ± 0.3 MPa for T5). Water vapor permeability (WVP) increased, and water solubility (WS) also decreased with gelatin mass rising in the composites. On the other hand, opacity did not vary significantly due to the films’ cassava starch and gelatin ratio. Finally, optimizing the mechanical and water barrier properties resulted in a mass ratio of 53/47 cassava starch/gelatin as the most appropriate for their application in food packaging, indicating their usefulness in the food-packaging industry.     

Conversion of γ-substituted bicyclo[2.2.1] (Z)-vinylsulfones to the corresponding (E)-allylsulfones

The preparation of bicyclo[2.2.1] (E)-allylsulfones starting from the corresponding (Z)-vinylsulfones is described. Starting from 2,3-bis(phenylsulfonyl)norbornadiene 1, the Michael addition of organometallic reagents followed by the base catalyzed isomerization affords (E)-allylsulfones in high yields. The procedure allows to obtain vinylidenic norbornenes which are characteristic nuclei of valuable biologically active compounds.