全文获取类型
收费全文 | 11744篇 |
免费 | 701篇 |
国内免费 | 377篇 |
专业分类
化学 | 7219篇 |
晶体学 | 78篇 |
力学 | 553篇 |
综合类 | 40篇 |
数学 | 2001篇 |
物理学 | 2931篇 |
出版年
2023年 | 114篇 |
2022年 | 258篇 |
2021年 | 347篇 |
2020年 | 372篇 |
2019年 | 313篇 |
2018年 | 269篇 |
2017年 | 243篇 |
2016年 | 450篇 |
2015年 | 435篇 |
2014年 | 408篇 |
2013年 | 717篇 |
2012年 | 804篇 |
2011年 | 893篇 |
2010年 | 549篇 |
2009年 | 528篇 |
2008年 | 698篇 |
2007年 | 688篇 |
2006年 | 589篇 |
2005年 | 511篇 |
2004年 | 460篇 |
2003年 | 377篇 |
2002年 | 340篇 |
2001年 | 210篇 |
2000年 | 129篇 |
1999年 | 150篇 |
1998年 | 113篇 |
1997年 | 100篇 |
1996年 | 124篇 |
1995年 | 96篇 |
1994年 | 120篇 |
1993年 | 119篇 |
1992年 | 75篇 |
1991年 | 77篇 |
1990年 | 75篇 |
1989年 | 60篇 |
1988年 | 56篇 |
1987年 | 52篇 |
1986年 | 44篇 |
1985年 | 82篇 |
1984年 | 92篇 |
1983年 | 46篇 |
1982年 | 65篇 |
1981年 | 49篇 |
1980年 | 51篇 |
1979年 | 62篇 |
1978年 | 53篇 |
1977年 | 39篇 |
1976年 | 46篇 |
1975年 | 28篇 |
1974年 | 42篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
11.
Abstract Gastrodigenin, also known as 4-hydroxybenzyl alcohol (HBA), is one of the main components of Gastrodia elata, which is a perfect lead compound of natural products. In order to get new active compounds, we modified the structure of HBA through esterification with carboxylic acid, and got a series of derivatives in which 4-hydroxybenzyl alcohol 2-naphthoate (NHBA) showed stronger antidepressant activity than HBA. In this paper, we firstly evaluated the antidepressant activity of NHBA by tail suspension test (TST) and forced swimming test (FST). Then, we carried out the biochemical assay and western blot to determine its mechanism. The results displayed that NHBA could increase the content of serotonin, dopamine, norepinephrine, γ-aminobutyric acid, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in mice brain. It suggested that NHBA exhibited an antidepressant-like effect through monoaminergic system, GABAergic system and BDNF/TrkB signaling pathways. 相似文献
12.
Vanessa R. Machado Louis P. Sandjo Giovanni L. Pinheiro Milene H. Moraes Mario Steindel Moacir G. Pizzolatti 《Natural product research》2018,32(3):275-281
The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2–11 were prepared by classical procedures. Including, five new esters derivatives 7–11, which were obtained by structural modifications in the isopropylidene fragment. All semisynthetic compounds and lupeol 1–11 were confirmed by 1H NMR, 13C NMR and HRMS. Their antiprotozoal activity was evaluated in vitro against L. amazonensis and T. cruzi. Derivative 6 showed the best antitrypanosomal activity (IC50 = 12.48 μg/mL) and the lowest cytotoxic derivative (CC50 = 161.50 μg/mL). The mechanism of action of the most active derivatives (4, 6 and 11) is not dependent from the enzyme trypanothione reductase. 相似文献
13.
Fabio Fagnani Sandro Zampieri 《Transactions of the American Mathematical Society》1997,349(5):1993-2006
In this paper we study symbolic dynamics over alphabets which are modules over a principal ideal domain, considering topological shifts which are also submodules. Our main result is the classification, up to algebraic and topological conjugacy, of the torsion-free, transitive, finite memory shifts.
14.
Summary We present an approximation method of a space-homogeneous transport equation which we prove is convergent. The method is very promising for numerical computation. Comparison of a numerical computation with an exact solution is given for the Master equation. 相似文献
15.
16.
Filippo Bracci Roberto Tauraso Fabio Vlacci 《Journal of Mathematical Analysis and Applications》2002,270(2):1131-473
Let f,g be two commuting holomorphic self-maps of the unit disc. If f and g agree at the common Wolff point up to a certain order of derivatives (no more than 3 if the Wolff point is on the unit circle), then f≡g. 相似文献
17.
Fabio Schoen 《Journal of Global Optimization》1991,1(3):207-228
In this paper stochastic algorithms for global optimization are reviewed. After a brief introduction on random-search techniques, a more detailed analysis is carried out on the application of simulated annealing to continuous global optimization. The aim of such an analysis is mainly that of presenting recent papers on the subject, which have received only scarce attention in the most recent published surveys. Finally a very brief presentation of clustering techniques is given. 相似文献
18.
M. Di Valentin A. Bisol G. Agostini G. Giacometti D. Carbonera 《Applied magnetic resonance》2006,30(3-4):555-576
A comparative electron paramagnetic resonance (EPR) study has been performed on a series of structurally related molecular triads which undergo photoinduced electron transfer and differ one from the other in terms of the acceptor or donor moieties. The molecular triads, C-P-C60, TTF-P-C60 and C-P-PF, share the same free-base, tetraarylporphyrin (P) as the primary electron donor, which after light excitation initiates the electron transfer process, but differ either in terms of the electron acceptor (fullerene derivative, C60, versus fluorinated free-base porphyrin, PF), or in terms of the final electron donor (carotenoid polyene, C, versus tetrathiafulvalene, TTF). All these molecular triads can be considered artificial photosynthetic reaction centers in their ability to mimic several key properties of the reaction center primary photochemistry. Photoinduced charge separation and recombination have been followed by time-resolved EPR in a glass of 2-methyltetrahydrofuran and in the nematic phase of the uniaxial liquid crystal E-7. All the triads undergo photoinduced electron transfer, with the generation of charge-separated states in both the low-dielectric environment of the 2-methyl-tetrahydrofuran glass and in anisotropic E-7 medium. Different photochemical pathways have been recognized depending on the specific donor and acceptor moieties constituting the molecular triads. In the presence of the tetrathiafulvalene electron donor singlet- and triplet-initiated electron transfer routes are concurrently active. Recombination to the low-lying carotenoid triplet state occurs in the carotene-based triads, while singlet recombination is the only active route for the TTF-P-C60 triad, where a low-lying triplet state is lacking. Long-lived charge separation has been observed in the case of TTF-P-C60: about 8 μs for the singlet-born radical pair in the glassy isotropic matrix and about 7 μs for the triplet-born radical pair in the nematic phase of E-7. For all the molecular triads, a weak exchange interaction (J?1 G) between the electrons in the final spin-correlated radical pair has been evaluated by simulation of the EPR spectra, providing evidence for superexchange electronic interactions mediated by the tetraarylporphyrin bridge. 相似文献
19.
In this paper we introduce the notion of symplectically asystatic Hamiltonian action on a Kahler manifold. In the algebraic
setting we prove that if a complex linear group G acts on a Kahler manifold in a symplectically asystatic fashion, then the
G-orbits are spherical. Finally, we give the complete classification of symplectically asystatic irreducible representations. 相似文献
20.
Giovanni Carini 《Rendiconti del Circolo Matematico di Palermo》1987,36(1):122-138
In this paper, along with the well established lines of the analytical mechanics, we aim to show an autonomous formulation of the fundamental principle of Lagrange-d'Alembert and of the subsequent Hamilton principle in classical mechanics of deformable continua in the sense that the afore—mentioned principles do not turn out to be a reformulation of the well known undefined equations of motion. 相似文献