Thermal stability of new complexes bearing both acrylate and aliphatic amine as ligands

This paper reports the investigation of the thermal stability of a series of new complexes with mixed ligands of the type [M(en)(C₃H₃O₂)₂]·nH₂O ((1) M=Ni, n=2; (2) M=Cu, n=0; (3) M=Zn, n=2; en=ethylenediamine and (C₃H₃O₂)=acrylate anion). The thermal behaviour steps were investigated in a nitrogen flow. The thermal transformations are complex processes according to TG and DTA curves including dehydration, ethylenediamine elimination as well as acrylate thermolysis. The final products of decomposition are the most stable metal oxides except for complex (2) that generates metallic copper.     

High field 207Pb spin-lattice relaxation in solid lead nitrate and lead molybdate

Spin-lattice relaxation rates of lead have been measured at 17.6 T (156.9 MHz) as a function of temperature in polycrystalline lead nitrate and lead molybdate. Comparing the results with relaxation rates measured at lower fields, it is found that at high fields and low temperature, chemical shift anisotropy (CSA) makes small but observable contributions to lead relaxation in both materials. At 17.6 T and 200 K, CSA accounts for about 15% of the observed relaxation rate. Above 300 K, the dominant relaxation mechanism even at 17.6 T is an indirect Raman process involving modulation of the (207)Pb spin-rotation tensor, as first proposed by Grutzner et al. [J. Am. Chem. Soc. 123, 7094 (2001)] and later treated theoretically in more detail by Vega et al. [Phys. Rev. B 74, 214420 (2006)]. The improved signal to noise ratio at high fields makes it possible to quantify relaxation time anisotropy by analyzing saturation-recovery functions for individual frequencies on the powder pattern line shape. No orientation dependence is found for the spin-lattice relaxation rate of either material. It is argued from examination of the appropriate theoretical expressions, derived here for the first time, that the lack of observable relaxation time anisotropy is probably a general feature of this indirect Raman mechanism.     

Posthypoxic behavioral impairment and mortality of Drosophila melanogaster are associated with high temperatures,enhanced predeath activity and oxidative stress

Hypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high. More basic research is needed to explain mortality after reperfusion and to develop adjunct neuroprotective therapies. Drosophila melanogaster (D.m.) is a suitable model to analyze hypoxia; however, little is known about the impacts of hypoxia and especially of the subsequent reperfusion injury on the behavior and survival of D.m. To address this knowledge gap, we subjected two wild-type D.m. strains (Canton-S and Oregon-R) to severe hypoxia (<0.3% O₂) under standardized environmental conditions in a well-constructed hypoxia chamber. During posthypoxic reperfusion (21% O₂), we assessed fly activity (evoked and spontaneous) and analyzed molecular characteristics (oxidative stress marker abundance, reactive oxygen species (ROS) production, and metabolic activity) at various timepoints during reperfusion. First, we established standard conditions to induce hypoxia in D.m. to guarantee stable and reproducible experiments. Exposure to severe hypoxia under defined conditions impaired the climbing ability and reduced the overall activity of both D.m. strains. Furthermore, a majority of the flies died during the early reperfusion phase (up to 24 h). Interestingly, the flies that died early exhibited elevated activity before death compared to that of the flies that survived the entire reperfusion period. Additionally, we detected increases in ROS and stress marker (Catalase, Superoxide Dismutase and Heat Shock Protein 70) levels as well as reductions in metabolic activity in the reperfusion phase. Finally, we found that changes in environmental conditions impacted the mortality rate. In particular, decreasing the temperature during hypoxia or the reperfusion phase displayed a protective effect. In conclusion, our data suggest that reperfusion-dependent death might be associated with elevated temperatures, predeath activity, and oxidative stress.Subject terms: Stroke, Molecular neuroscience     

Subordination in the sense of Bochner of L p -semigroups and associated Markov processes

We show that the subordination induced by a convolution semigroup（subordination in the sense of Bochner）of a C0-semigroup of sub-Markovian operators on an Lpspace is actually associated to the subordination of a right（Markov）process.As a consequence,we solve the martingale problem associate with the Lp-infinitesimal generator of the subordinate semigroup.We also prove quasi continuity properties for the elements of the domain of the Lp-generator of the subordinate semigroup.It turns out that an enlargement of the base space is necessary.A main step in the proof is the preservation under such a subordination of the property of a Markov process to be a Borel right process.We use several analytic and probabilistic potential theoretical tools.     

A qualitative study of amlodipine and its related compounds by electrospray ionization tandem mass spectrometry

A comprehensive structural analysis of amlodipine and certain related compounds was performed by electrospray ionization tandem mass spectrometry. Triple quadrupole and quadrupole time-of-flight instruments were used to provide collision-induced dissociation and accurate mass measurement for selected product and second-generation product ions. A unique ion rearrangement was observed, which was found to be characteristic of certain dihydropyridines. This study provides a fundamental understanding of the fragmentation of these compounds. The structural elucidation of an unknown impurity is presented as an example.     

The relative roles of vowels and consonants in discriminating talker identity versus word meaning

Three experiments tested the hypothesis that vowels play a disproportionate role in hearing talker identity, while consonants are more important in perceiving word meaning. In each study, listeners heard 128 stimuli consisting of two different words. Stimuli were balanced for same/different meaning, same/different talker, and male/female talker. The first word in each was intact, while the second was either intact (Experiment 1), or had vowels ("Consonants-Only") or consonants wels-Only") replaced by silence (Experiments 2, 3). Different listeners performed a same/ different judgment of either talker identity (Talker) or word meaning (Meaning). Baseline testing in Experiment 1 showed above-chance performance in both, with greater accuracy for Meaning. In Experiment 2, Talker identity was more accurately judged from Vowels-Only stimuli, with modestly better overall Meaning performance with Consonants-Only stimuli. However, performance with vowel-initial Vowels-Only stimuli in particular was most accurate of all. Editing Vowels-Only stimuli further in Experiment 3 had no effect on Talker discrimination, while dramatically reducing accuracy in the Meaning condition, including both vowel-initial and consonant-initial Vowels-Only stimuli. Overall, results confirmed a priori predictions, but are largely inconsistent with recent tests of vowels and consonants in sentence comprehension. These discrepancies and possible implications for the evolutionary origins of speech are discussed.     

Development of New Efficient Adsorbent by Functionalization of Mg3Al-LDH with Methyl Trialkyl Ammonium Chloride Ionic Liquid

The present paper describes a new way of obtaining an efficient adsorbent material by functionalization of Mg₃Al layered double hydroxides (LDH) with methyl trialkyl ammonium chloride-ionic liquid (IL) using two methods: ultrasound and cosynthesis. Layered double hydroxides are good solid support for the functionalization with ionic liquids due to their well-ordered structure. The immobilization of the ILs in suitable solid supports combine the advantages of the ILs with the properties of the solid supports bringing more benefits such as use of lower quantity of ILs and avoiding of ILs loss in the aqua phase which overall decrease the treatment costs. In case of ultrasound method of functionalization is assured a uniform distribution of IL on the solid surface, but through immobilization by cosynthesis due to the tunable properties of LDH, is assured an intercalation of the ILs between the LDH layers. This fact was highlighted by the X-ray diffraction (RXD), scanning electron microscopy (SEM) analyses and Fourier-transform infrared (FTIR) spectroscopy of the obtained adsorbent. The added value brought by the functionalization of Mg₃Al with the studied IL was underlined by the adsorption studies conducted in the treatment process of water with diclofenac content. Kinetic, thermodynamic, and equilibrium studies were performed. DCF adsorption onto the studied materials correspond to a chemisorption, the pseudo-second-order kinetic model describing the most accurately the experimental data. DCF adsorption onto the studied materials occurs as a heterogeneous process, with the experimental data fitting best with the SIPS isotherm. The sample obtained through cosynthesis developed a maximum adsorption capacity of 648 mg/g.     

Tetranuclear, Oxygen Centered Copper(II) Clusters Linked Together with Guanidine-Guanidinate Ligands

The reaction of copper(I) chloride with Htbo (1,4,6-triazabicyclo[3.3.0]oct-4-ene) under reflux in THF with oxidation by oxygen, produces a neutral cluster comprising two oxo-tetra-copper(II) units connected by six tbo⁻ bridges three of them bind two and the other three bind four metals; each unit also contains three chlorine bridges and a Htbo terminal ligand. Two different X-ray crystal structures (1a, 1b) have been determined and the magnetic behavior has been studied. The molar magnetic susceptibility measurements indicate strong exchange interactions within an oxo cluster with coupling constants of J ₁ = −163 cm⁻¹ and J ₂ = −1.1 cm⁻¹, and a weak interaction across the guanidinate bridges of J ₃ = −5.2 cm⁻¹ of the octa-Cu^II cluster.