全文获取类型
收费全文 | 550篇 |
免费 | 3篇 |
国内免费 | 2篇 |
专业分类
化学 | 426篇 |
晶体学 | 1篇 |
力学 | 22篇 |
数学 | 48篇 |
物理学 | 58篇 |
出版年
2023年 | 3篇 |
2022年 | 12篇 |
2021年 | 12篇 |
2020年 | 8篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 20篇 |
2012年 | 11篇 |
2011年 | 37篇 |
2010年 | 17篇 |
2009年 | 15篇 |
2008年 | 40篇 |
2007年 | 37篇 |
2006年 | 37篇 |
2005年 | 44篇 |
2004年 | 27篇 |
2003年 | 34篇 |
2002年 | 20篇 |
2001年 | 6篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 8篇 |
1996年 | 11篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 3篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 9篇 |
1980年 | 4篇 |
1978年 | 5篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1970年 | 2篇 |
1942年 | 2篇 |
排序方式: 共有555条查询结果,搜索用时 15 毫秒
551.
Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine
Francesca Cuomo Andrea Ceglie Giuseppe Colafemmina Raimondo Germani Gianfranco Savelli Francesco Lopez 《Colloids and surfaces. B, Biointerfaces》2011,82(2):277-282
In this work unilamellar liposomes doped with a novel non-ionic 5′-Uridine-head nucleolipid, Lauroyl Uridine (LU), were prepared and characterized for their ability to interact with the polynucleotide polyadenylic acid (poly-A). Vesicles, were made up of the cationic lipid DOTAP (1,2-Dioleoyl-3-Trimethylammonium-Propane), the zwitterionic lipid DOPE (1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine), and the novel amphiphile Lauroyl Uridine. The influence of the non-ionic nucleolipid on essential liposomes properties, such as the structure and net charge was first investigated by a comparative analysis performed on the different lipoplex preparations by means of ζ-potential and size measurements. Both structure and net charge of liposomes were shown to be not modified by the presence of the non-ionic nucleolipid.The role of the synthetic lipid inserted as anchor in the liposome bilayer in the condensation process between vesicles and the polynucleotide poly-A was then analyzed by UV–vis, Circular Dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopies. The data presented comparative UV–vis analyses that evidenced the occurrence of staking interactions in the poly-A only in LU containing lipoplexes. CD and NMR studies indicated the presence of H-bonding interaction between Lauroyl Uridine containing vesicles and the polynucleotide poly-A. The results presented in this work support a role for Lauroyl Uridine in A-U molecular recognition, thus, suggesting that cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine could represent a model system to study molecular interactions among single stranded polynucleotides and lipid anchor bearing the complementary bases. 相似文献
552.
Gianfranco Pacchioni 《ChemInform》2000,31(35):no-no
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献
553.
Gianfranco Pacchioni Sabrina Sicolo Cristiana Di Valentin Mario Chiesa Elio Giamello 《ChemInform》2008,39(44):no-no
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献
554.
Dr. Matteo Corrieri Dr. Lucia De Crescentini Prof. Fabio Mantellini Dr. Giacomo Mari Dr. Stefania Santeusanio Prof. Gianfranco Favi 《European journal of organic chemistry》2023,26(21):e202300242
An oxidative cyclization of electron-rich α-arylhydrazones promoted by phenyliodine bis(trifluoroacetate) (PIFA) has been accomplished. This metal-free, chemoselective transformation allows to obtain synthetically and medicinally important N-amino-1H-indoles, obviating the need for pre-functionalization of substrates. 相似文献