Comparative Raman spectroscopy study of sulfonate-substituted triphenylphosphines

A comparative Raman spectroscopy study of triphenylphosphine (TPP), monosulfonated triphenylphosphine (TPPMS) and trisulfonated triphenylphosphine (TPPTS) is reported. The characteristic modes for each molecule were evidenced and we suggest assignments for the majority of the modes. A detailed study of the phenyl breathing mode (around 1000 cm⁻¹) shows that in the case of TPP, the three rings are nonequivalent, whereas for TPPTS, the sulfonate substituant seems to contribute to stabilise the molecule structure so as the rings are equivalent. The TPPMS spectrum is a medium case between the extreme cases of TPP and TPPTS and presents the characteristics of the two previous spectra.     

Study of the out-of-plane emission of protons and light fragments in symmetric heavy-ion collisions

Midrapidity protons from²⁰⁹Bi+²⁰⁹Bi collisions were measured with the Kaon Spectrometer at SIS at incident energies of E _Lab /A=400, 700 and 1000 MeV. Additionally, light fragments were analysed at 400 MeV. We have investigated the azimuthal emission pattern of the particles relative to the reaction plane as function of transverse momentum, bombarding energy and impact parameter. We observe an enhanced emission of particles perpendicular to the reaction plane at all bombarding energies. The ratio of the number of particles emitted out-of-plane/in-plane increases strongly with the particles transverse momentum. The anisotropy decreases with increasing beam energy. Composite particles show a much stronger effect than protons.     

Pion production in mass- symmetric heavy ion collisions at 0.8–1.8 AGeV

Double differential cross sections of positively charged pions and protons have been measured in nuclear collisions of mass-symmetric systems (Ne+NaF, Ni+Ni, Au+Au, Bi+Pb) at incident energies between 0.8 and 1.8 AGeV as a function of the centrality of the reaction. Using a magnetic spectrometer pions and protons were detected with laboratory angles between 40 and 48 degrees, and with momenta up to about 1400 MeV/c. This setting allows for the study of pions and protons emitted close to midrapidity. The center-of-mass pion spectra deviate from a Boltzmann distribution. The inverse slope parameters of the high-energetic pions are smaller than those of the proton spectra and they exhibit a weaker centrality dependence. A scenario is presented where the shape of the pion spectra reflects the decay kinematics of nucleonic resonances embedded in the thermal and the collective motion of the nucleons in the reaction zone. The number of emitted pions per participating nucleon is higher for light than for heavy mass systems. For a given mass system, the total pion multiplicity increases linearly with the number of participating nucleons, whereas the multiplicity of high-energy pions increases more than linearly. This result is consistent with a scenario where the high-energy pions are produced in multiple energetic baryon-baryon collisions occurring in the high-density phase of the collision.     

Theoretical Investigations of the Inclusion Processes of (4-tert-butylphenyl) (3-sulfonatophenyl) (phenyl) Phosphine in β-Cyclodextrin

Quantum mechanical calculations on the (4-tert-butylphenyl)(3-sulfonatophenyl) (phenyl) phosphine/-cyclodextrin inclusion complex werecarried out using semi-empirical calculations. Inclusion process pathways are describedand the most probable structures of the 1:1 complex are sought through a global potentialenergy scan. The calculations suggest that the most stable structure is obtained whenthe aromatic ring bearing the tert-butyl group is includedinto the hydrophobic cavity of the -cyclodextrin from theside of the primary hydroxyl groups.     

5-Aminolevulinic Acid-induced Protoporphyrin IX Levels in Tissue of Human Malignant Brain Tumors

Protoporphyrin IX (PpIX) produced from exogenous, orally administered 5-aminolevulinic acid (ALA) displays high tumor-selective uptake and is being successfully employed for fluorescence-guided resection (FGR) of human malignant gliomas. Furthermore, the phototoxicity of PpIX can be utilized for photodynamic therapy (PDT) of brain tumors, which has been shown previously. Here, the absolute PpIX concentration in human brain tissue was investigated following oral ALA administration (20 mg kg⁻¹ b.w.). An extraction procedure was used to quantify PpIX in macroscopic tissue samples, weighing 0.013–0.214 g, obtained during FGR. The PpIX concentration was significantly higher in vital grade IV tumors (5.8 ± 4.8 μm , mean ± SD, range 0–28.2 μm , n = 8) as compared with grade III tumors (0.2 ± 0.4 μm , mean ± SD, range 0–0.9 μm , n = 4). There was also a large heterogeneity within grade IV tumors with PpIX displaying significantly lower levels in infiltration zones and necrotic regions as compared with vital tumor parts. The average PpIX concentration in vital grade IV tumor parts was in the range previously shown sufficient for PDT-induced tissue damage following irradiation. However, the feasibility of PDT for grade III brain tumors and for grade IV brain tumors displaying mainly necrotic tissue areas without solid tumor parts needs to be further investigated.