Dynamic thermoelastic effects for half-planes and half-spaces with nearly-planar surfaces

The effects of non-planarity on the dynamic surface temperature changes induced for plane-strain and 3D problems on the nearly-planar surfaces of, respectively, coupled thermoelastic half-planes and half-spaces by surface heat fluxes are treated. The nearly-planar nature of the surfaces allows the problem solutions to be written, following a standard perturbation scheme, as series expansions in a dimensionless surface contour amplitude parameter. The first, or zero-order, terms represent the ideal (planar) surface solutions, while the second, or first-order, terms represent corrections for non-planarity.Because the characteristic thermoelastic time is of O(10^–7)s, large-time asymptotic forms of the exact integral transform solutions can be used. These can be inverted exactly and used in Green's function operations to yield analytic, or integrals of analytic, expressions. Two types of thermal loading for the half-plane and yet a third type of thermal loading for the half-space are considered. Comparison of the zero- and first-order surface temperature changes for each case indicate that non-planarity gives rise for large times to changes in surface regions beyond those predicted by an ideal surface analysis. Moreover, the magnitudes of these changes can be more significant than the ideal surface results.     

Synthesis of phosphinate analogues of the phospholipid anti-tumour agent hexadecylphosphocholine (miltefosine)

Efficient synthesis of phosphinate analogues (in six steps and 68-69% overall yields) of the anti-tumour agent miltefosine are reported, which involve a radical hydrophosphinylation addition reaction followed by conversion to the P(III) silyloxy intermediate and Michael-type addition as the key steps.     

Sesquiterpenes from Chrysoma Pauciflosculosa

Abstract

The aerial parts of Chrysoma pauciflosculosa (syn. Solidago pauciflosculosa) gave two new sesquiterpenes, (+)-β-turmerone and a bisabolane endoperoxide, together with the known (-)-α-trans-bergamotene and (+)-β-sesquiphellandrene. When exposed to air and light, (+)-β-turmerone and (+)-β-sesquiphellandrene gave oxidative degradation products, involving hydroperoxide intermediates. Photosensitized singlet oxygen reactions of (+)-β-turmerone provided a series of bisabolane-type endoperoxides. The structures of the natural compounds as well as those of the degradation products and derivatives were elucidated by chemical and spectroscopic methods, mainly NMR and MS. Aqueous solutions of (+)-β-turmerone,(+)-β-sesquiphellandrene and (-)-α-trans-bergamotene were tested for their effects on the germination and radicle growth of three Florida sandhill species, Rudbeckia hirta, Schizachyrium scoparium, Leptochloa dubia, as well as Lactuca sativa. (+)-β-Turmerone significantly inhibited germination of L. sativa, stimulated radicle growth of L. sativa and S. scoparium at the 10^?4 M level, and mildly inhibited radicle growth of R. hirta, as did (+)-β-sesquiphellandrene. (-)-α-trans-Bergamotene stimulated germination of S. scoparium and L. sativa and significantly enhanced radicle growth of S. scoparium.     

Comparative studies of localized buckling in sandwich struts with different core bending models

Analytical models with geometric non-linearities accounting for interactions between local and global instability modes leading to localized buckling in sandwich struts are formulated. For the core material response, two increasingly sophisticated bending models are compared against each other: Timoshenko beam theory (TBT) and Reddy-Bickford beam theory (RBT). Numerical solutions of the analytical models are validated with the commercial finite element code ABAQUS. It is found that there is a small but significant difference in the critical load between the two models and that the previously obtained solution slightly underestimates the linear buckling strength. More importantly, it is found that the RBT model predicts the onset of interactive buckling before the TBT model and, according to the results from the finite element study, matches the actual behaviour of a strut in both its initial and advanced post-buckling states with excellent correlation.     

Effect of Local DBD Plasma Actuation on Transition in a Laminar Separation Bubble

This work examines the effect of local active flow control on stability and transition in a laminar separation bubble. Experiments are performed in a wind tunnel facility on a NACA 0012 airfoil at a chord Reynolds number of 130 000 and an angle of attack of 2 degrees. Controlled disturbances are introduced upstream of a laminar separation bubble forming on the suction side of the airfoil using a surface-mounted Dielectric Barrier Discharge plasma actuator. Time-resolved two-component Particle Image Velocimetry is used to characterise the flow field. The effect of frequency and amplitude of plasma excitation on flow development is examined. The introduction of artificial harmonic disturbances leads to significant changes in separation bubble topology and the characteristics of coherent structures formed in the aft portion of the bubble. The development of the bubble demonstrates strong dependence on the actuation frequency and amplitude, revealing the dominant role of incoming disturbances in the transition scenario. Statistical, topological and linear stability theory analysis demonstrate that significant mean flow deformation produced by controlled disturbances leads to notable changes in stability characteristics compared to those in the unforced baseline case. The findings provide a new outlook on the role of controlled disturbances in separated shear layer transition and instruct the development of effective flow control strategies.     

Rapid access to the tricyclic spirotetronic core of abyssomicins

[reaction: see text] Abyssomicins, a novel class of polyketide antibiotics, are characterized by an unprecedented spirotetronic tricyclic subunit in their structure. In this letter, a short synthesis of a suitably functionalized tricyclic precursor of abyssomicins is reported. Key steps of the synthesis are (i) the highly stereoselective Al(III)-tethered Diels-Alder reaction and (ii) the tandem Dieckmann cyclization/TBS trapping of the C9 hydroxyl group followed by a regioselective intramolecular epoxide opening for the assembly of the target tricyclic structure.     

One-pot regioselective synthesis and X-ray crystal structure of a stable [60]fullerene trisadduct with the e(edge),e(face),trans-1 addition pattern

The Bingel functionalisation of C(60) with a structurally novel tether equipped with three reactive malonate groups afforded a C(2v)-symmetrical e(edge),e(face),trans-1 trisadduct in a complete regioselective manner and in an excellent yield of 65%. The [60]fullerene trisadduct showed pronounced ability to crystallise and gave X-ray quality single crystals for analysis.     

Emission of stress waves during fracture

Emission of both longitudinal and surface (Rayleigh) waves during fracture of plates under conditions of plane stress and plane strain were studied experimentally. The non-equilibrated tensile stress in the fractured section of the plate creates an elastic wave, which travels radially along the plate at the sound speed. Moreover, the high surface deformation around the crack tip, due to the high stress concentration there, propagates as a surface wave following fracture of this zone, at the respective Rayleigh wave speed with a circular wavefront. The influence of the thickness of the plate and the type of fracture (brittle or ductile) was examined and interesting results were derived, by utilizing a high speed photography technique.