排序方式: 共有160条查询结果,搜索用时 0 毫秒
71.
We report a simple method that allows to obtain external reflectance infrared spectra in strongly acidic solutions using a fluorite window without damaging it. The method is demonstrated by measuring the infrared spectra of carbon monoxide adsorbed on a nickel electrode in 7.5% and 28% aqueous HCl solutions. 相似文献
72.
Dr. Tania Lozano-Cruz Dr. Gema Alcarraz-Vizán Prof. Dr. F. Javier de la Mata Sara de Pablo Dr. Paula Ortega Dr. Yorley Duarte Felipe Bravo-Moraga Prof. Fernando D. González-Nilo Dr. Anna Novials Prof. Dr. Rafael Gómez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(34):7609-7621
The most common denominator of many of the neurodegenerative diseases is badly folded protein accumulation, which results in the formation of insoluble protein deposits located in different parts of the organism, causing cell death and tissue degeneration. Dendritic systems have turned out to be a promising new therapeutic approach for the treatment of these diseases due to their ability to modulate the folding of these proteins. With this perspective, and focused on type 2 diabetes (T2D), characterized by the presence of deposits containing the amyloidogenic islet amyloid polypeptide (IAPP), we demonstrate how different topologies of cationic carbosilane dendrimers inhibit the formation of insoluble protein deposits in pancreatic islets isolated from transgenic Tg-hIAPP mice. Also, the results obtained by the modification of dendritic carbosilane wedges with the chemical chaperone 4-phenylbutyric acid (4-PBA) at the focal point confirmed their potential as anti-amyloid agents with a concentration efficiency in their therapeutic action five orders of magnitude lower than that observed for free 4-PBA. Computational studies, which determined the main interaction between IAPP and dendrimers at the atomic level, support the experimental work. 相似文献
73.
74.
75.
Pilar Viñas Natalia Campillo Gema Férez Melgarejo Mª Isabel Vasallo Ignacio López-García Manuel Hernández-Córdoba 《Journal of chromatography. A》2010,1217(32):5197-5203
A liquid chromatography with diode array detection coupled to dual electrospray atmospheric pressure chemical ionization time-of-flight mass spectrometry (HPLC/ESI-APCI-TOF-MS) method is described for the rapid determination of five monophosphate nucleotides (cytidine 5′-monophosphate, uridine 5′-monophosphate, adenosine 5′-monophosphate, inosine 5′-monophosphate and guanosine 5′-monophosphate) in baby foods. The method is based on the deproteinisation of foods and direct analysis of nucleotides by ion-pair HPLC using isocratic elution with a mobile phase of 5% (v/v) methanol and 95% (v/v) 0.1 M formate buffer (pH 5.5) containing 0.01 M N,N-dimethylhexylamine (DMHA) at a flow-rate of 0.7 mL min−1. The HPLC was hyphenated with two different detection systems, photodiode-array (DAD) and ESI-APCI-TOF-MS in negative mode. The method was validated for linearity, detection and quantitation limits, selectivity, accuracy and precision. The recoveries obtained for spiked samples were satisfactory for all the analytes. The method was successfully applied to the analysis of nucleotides in different baby and/or functional food samples, as cereals, purees and dairy products. A study was also carried out on the stability of nucleotides in acidified dairy infant food with pasteurized yoghourt and follow-on formulae samples stored at room temperature and at 30 °C. 相似文献
76.
Fustero S García Sancho A Chiva G Sanz-Cervera JF del Pozo C Aceña JL 《The Journal of organic chemistry》2006,71(8):3299-3302
Starting with a fluorous analogue of 2-(trimethylsilyl)ethanol, we have designed an easy method for preparing a new fluorous tag ((F)TMSE) for the protection of carboxylic acids. Because mild conditions are employed in the tag cleavage (TBAF in the presence of 4 A molecular sieves, which prevent racemization), this tag can be advantageously used in the synthesis of peptides and modified peptides, as we have demonstrated with several examples, including the fluorous synthesis of short alpha- and beta-peptides as well as of modified fluorinated retropeptides. 相似文献
77.
78.
Kazimieras Anusevicius Rita Vaickelioniene Vytautas Mickevicius Gema Mikulskiene 《Journal of heterocyclic chemistry》2013,50(2):309-314
A new potentially biologically active N‐(4‐chloro/iodophenyl)‐N‐carboxyethyl‐β‐alanine derivatives ( 2 , 2a , 2b , 3 , 3a , 3b , 4 , 4a , 4b , 8 , 8a , 8b , 9 , 9a , 9b ) and products of their cyclization 6 , 6a , 6b , 7 , 7a , 7b , 10 , 10a , 10b , 11 , 11a , 11b were obtained and characterized by the methods of 1H‐NMR, 13C‐NMR, IR, mass spectroscopy, and elemental analysis. 相似文献
79.
Microchimica Acta - Two types of modified electrodes, viz. sol-gel and sol-gel-poly(dimethyldiallylammonium chloride (PDMDAAC) carbon composite electrodes, were synthesised and characterised. In... 相似文献
80.
Stefan Heuser David G. Barrett Benjamin Bonnier Maria Luz De La Puente Rainer Riedl Gema Sanz Gil David J. Steggles Andreas G. Weichert 《Tetrahedron letters》2006,47(16):2675-2678
A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates. 相似文献