Synthesis,and crystal and molecular structures of anabasinium O,O-dialkyl phosphorothioates

The synthesis has been effected of anabasinium O,O-dialkyl phosphorothioates. The crystal and molecular structures of the complex compounds obtained have been determined by the method of x-ray structural analysis. It has been established that the cations and anions of the anabasinium O,O-dialkyl phosphorothioates are combined into cyclic associates each including two anions and two cations with different conformations.Institute of Organic Synthesis and Coal Chemistry, Academy of Sciences of the Kazakh SSR. A. N. Nesmayanov Institute of Organometallic Compounds, Academy of Sciences of the USSR, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 500–505, July–August, 1990.     

Synthesis of esters of α-vinyloxyethylcarbamodithioic acid

Mono and diesters of 2-vinyloxyethylcarbamodithioic acid were synthesized by the reaction of (1-p-nitrophenyl)-2-vinyloxyethylaminoethanol with carbon disulfide. 3-[2-(Vinyloxyethyl)]-5-(4-nitrophenyl)-1,3-thiazolidine-2-thione was prepared and its structure was proved by X-ray diffraction analysis.     

Synthesis and antioxidant activity of alkaloid- and amine-containing salts of 1,3,4-thiadiazole-2,5-disulfonic acid

1,3,4-Thiadiazole-2,5-disulfonic acid was synthesized by oxidation of 2,5-dimercapto-1,3,4-thiadiazole, and onium salts of this acid were prepared by its reactions with selected alkaloids and secondary amines. The antioxidant activity of the compounds synthesized was evaluated.     

Synthesis and crystal structure of cytisino-<Emphasis Type="Italic">N</Emphasis>-(2-hydroxyethyl)-thiocarbamide

A thiourea derivative of the alkaloid cytisine was synthesized by reacting it with 1-propargyloxyethoxyethylisothiocyanate. It was shown that the synthesized acetal thiourea derivative underwent hydrolysis in acidic medium to cytisino-N-(2-hydroxyethyl)-thiocarbamide, the molecular structure of which was confirmed by an x-ray structure analysis. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 56–58, January–February, 2009.     

Synthesis of N-alkaloidacyl derivatives of phenothiazine

Compounds in which cytisine, anabasine, D-pseudoephedrine, and L-ephedrine fragments are linked to the phenothiazine nitrogen atom via acyl group were synthesized. These compounds are potential drugs, and their activity was confirmed by computer prediction using PASS software.     

Synthesis of organophosphorus derivatives of lupinine and solasodine and investigation of their cholinergic activities

The synthesis of lupinine O-(dialkyl phosphate)s and of solasodine O-(diethyl phosphate) has been achieved under the conditions of phase-transfer catalysis-and their antienzyme activities have been studied.Institute of Organic Synthesis and Coal Chemistry, Kazakhstan Academy of Sciences, Karaganda. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 541–542, September–October, 1992.     

Synthesis and fungicidal activity of alkaloid-containing carbohydrates

N-Glycosylamines, triethylammonium salt of xylosyl-and glucosylbenzyldithiocarbamates, and their derivatives containing fragments of alkaloids were synthesized; some of these substances exhibit fungicidal activity.