全文获取类型
收费全文 | 145篇 |
免费 | 5篇 |
专业分类
化学 | 95篇 |
晶体学 | 1篇 |
力学 | 1篇 |
数学 | 19篇 |
物理学 | 34篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 9篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 1篇 |
2014年 | 9篇 |
2013年 | 12篇 |
2012年 | 15篇 |
2011年 | 10篇 |
2010年 | 9篇 |
2009年 | 4篇 |
2008年 | 12篇 |
2007年 | 2篇 |
2006年 | 4篇 |
2005年 | 2篇 |
2004年 | 2篇 |
2003年 | 5篇 |
2001年 | 1篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有150条查询结果,搜索用时 31 毫秒
101.
102.
103.
Ferrocene conjugated copper(II) complexes of terpyridine and traditional Chinese medicine (TCM) anticancer ligands showing selective toxicity towards cancer cells
下载免费PDF全文
![点击此处可从《应用有机金属化学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Banashree Deka Arnab Bhattacharyya Sanjoy Mukherjee Tukki Sarkar Kiran Soni Samya Banerjee Kandarpa K. Saikia Sasanka Deka Akhtar Hussain 《应用有机金属化学》2018,32(4)
Six novel mixed‐ligand copper(II) complexes, namely, [Cu(R‐tpy)(L)]NO3 ( 1–6 ), where R‐tpy is 4′‐phenyl‐2,2′:6′,2′′‐terpyridine (Ph‐tpy; 1–3 ) and 4′‐ferrocenyl‐2,2′:6′,2′′‐terpyridine (Fc‐tpy; 4–6 ), L is the bidentate O,O donor monoanion of plumbagin (5‐hydroxy‐2‐methyl‐1,4‐naphthoquinone; plum in 1 , 4 ), chrysin (5,7‐dihydroxyflavone; chry in 2 , 5 ) and curcumin (bis(4‐hydroxy‐3‐methoxyphenyl)‐1,6‐diene‐3,5‐dione; curc in 3 , 6 ) have been synthesized and characterized and their in vitro cytotoxicity against cancer cells is evaluated. The energy optimized structures and the frontier orbitals of the complexes have been obtained from the DFT calculations. Complexes 4–6 with a conjugated ferrocenyl moiety and TCM anticancer ligands, namely, plum (in 4 ), chry (in 5 ) and curc (in 6 ) showed potent cytotoxicity giving respective IC50 values of 1.2 μM, 0.62 μM and 0.21 μM in HeLa and 2.0 μM and 1.0 μM and 0.34 μM in MCF‐7 cancer cells while being much less toxic to MCF‐10A normal cells (IC50: 8.3‐17.1 μM). In contrast, complexes 1–3 with a conjugated phenyl moiety were appreciably less toxic to HeLa cells with respective IC50 values of 10.4 μM, 8.1 μM and 5.5 μM when compared with their ferrocenyl analogues 4–6 . Mechanistic studies using Hoechst staining and Annexin‐V‐FITC assays on cancer cells revealed an apoptotic pathway of cell death induced by the complexes. Fluorescence imaging study showed that complex 6 having curcumin as ligand localized primarily in the mitochondria of HeLa cells. Thus, we demonstrate in this study that ferrocene conjugation to copper(II) complexes of TCM anticancer ligands significantly increases the selectivity and cytotoxicity of the resulting complexes towards cancer cells over normal cells. 相似文献
104.
Four task-specific –SO3H functionalized imidazolium ionic liquids (ILs) were investigated for Brønsted acidities by Hammett functions. After knowing their thermal stabilities, the catalytic activity was observed for the preparation of 2-styrylquinolines by following consecutive Friedländer and Knoevenagel reactions in solvent-free thermal energy. The acidity order ([Dsim][OOCCF3] > [Dsim][OTs] > [Dsim][OOCCl3] > [Msim][OOCCF3]) of three ILs was consistent with their activity order observed in the acid-catalyzed synthesis of 2-styrylquinolines under solvent-free conditions at 90° C, with the exception of [Dsim][OTs]. The best catalytic activity was shown by 25 mol% of [Dsim][OOCCF3] IL. The less acidic IL required 50 mol% to give good yield of 2-styrylquinolines under the optimized condition. 相似文献
105.
Abhishek GoswamiPartha Pratim Saikia Bishwajit SaikiaDevdutt Chaturvedi Nabin C. Barua 《Tetrahedron letters》2011,52(40):5133-5135
A novel route for the stereoselective total synthesis of (R)-rugulactone 1 has been developed, starting from substituted epoxide 4 and 3-phenylpropionaldehyde 5 employing Julia-Kocienski olefination as a key step to construct E-configured α,β-unsaturated keto-group. The overall yield of the synthesized rugulactone is 19.94% and is better than the reported methods. 相似文献
106.
Exploiting the diene nature of 6-[1-aza-2-(dimethylamino)prop-l-enyl]-1,3-dimethyluracil (2), novel 5-aryl-pyrido[2,3-d]pyrimidines (5a–h) have been synthesized. The reaction proceeds through a triene intermediate whose structure has been conclusively established by single crystal X-ray analysis. Role of water is intriguing as the reaction can be stopped at the intermediate stage. Synthesized compounds have been screened for possible antibacterial properties and results showed modest activity. 相似文献
107.
We express the number of ${\mathbb{F}_q}$ -points on the hyperelliptic curve ${\alpha{y}^2=\beta{x}^f + \gamma}$ in terms of Gaussian hypergeometric series. We also find some special values of ${{_{2}}F_1}$ -Gaussian hypergeometric series containing characters of order 3 and 4 as parameters. 相似文献
108.
Sandipan Talukdar Shubhranshu Zutshi K. S. Prashanth Kandarpa K. Saikia Parveen Kumar 《Applied biochemistry and biotechnology》2014,172(6):3026-3041
In the past few decades, genome-based approaches have contributed significantly to vaccine development. Our aim was to identify the most conserved and immunogenic antigens of Streptococcus pneumoniae, which can be potential vaccine candidates in the future. BLASTn was done to identify the most conserved antigens. PSORTb 3.0.2 was run to predict the subcellular localization of the proteins. B cell epitope prediction was done for the immunogenicity testing. Finally, BLASTp was done for verifying the extent of similarity to human proteome to exclude the possibility of autoimmunity. Proteins failing to comply with the set parameters were filtered at each step. Based on the above criteria, out of the initial 22 pneumococcal proteins selected for screening, pavB and pullulanase were the most promising candidate proteins. 相似文献
109.
Lakhinath Saikia Dhrubajyoti Talukdar Ramesh C. Deka Ashim J. Thakur 《Journal of heterocyclic chemistry》2013,50(5):1031-1038
KI‐VO(acac)2‐H2O2 in aqueous ethanolic medium with acetic acid as additive has been found to iodinate pyrimidinediones and aromatic amines. The methodology is mild, efficient, and environmentally benign. Density functional theory‐based reactivity parameters support the experimentally observed reactivity of pyrimidinedione derivatives. 相似文献
110.
New supported acidic organocatalysts were prepared by the impregnation of three carboxylic acids (CF3COOH, CCl3COOH, and CH3COOH) on silica support at room temperature in diethyl ether. The catalysts were characterized by scanning electron microscopy, energy dispersion X-ray analysis (EDX), Brunauer-Emmett-Teller-surface-area-analysis (BET), thermogravitational analysis, Fourier transform infrared, and powder X-ray diffractometry analysis. These solid acids were observed as highly efficient reusable catalysts at room temperature for the selective synthesis of β-amino carbonyl compounds via Mannich-type reactions of acetophenone, arylamine and arylaldehydes using two different conditions in CH2Cl2 solution and solvent-free grinding within a short time. The more acidic two catalysts could be recycled for up to five cycles with a small loss in catalytic activity. 相似文献