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81.
Srinivas D Gonnade R Ravindranathan S Sanjayan GJ 《The Journal of organic chemistry》2007,72(18):7022-7025
In this note, we describe the design, synthesis, and structural studies of novel hybrid foldamers derived from Aib-Pro-Adb building blocks that display repeat beta-turn structure motif. The foldamer having a conformationally constrained aliphatic-aromatic amino acid conjugate adopts a well-defined, compact, three-dimensional structure, governed by a combined conformational restriction imposed by the individual amino acids with which it is made of. Conformational investigations by single-crystal X-ray and solution-state NMR studies were undertaken to investigate the conformational preference of these foldamers with a hetero-backbone. Our findings suggest that constrained aliphatic-aromatic amino acid conjugates would offer new avenues for the de novo design of hybrid foldamers with distinctive structural architectures. 相似文献
82.
Abstract Graft copolymerization of methyl methacrylate onto nylon 6 was investigated in aqueous perchloric acid medium using thallium(III) ions as initiator. The rate of grafting was evaluated by varying the concentrations of monomer, initiator, acid, and temperature. The rate of grafting was found to increase with an increase of both monomer and initiator concentrations. The graft yield was found to increase with an increase in the acid concentration up to 0.49 mL?1, and beyond this concentration of perchloric acid the graft yield was found to decrease. It also increased with an increase of temperature. From the Arrhenius plot the overall activation energy was found to be 3.9 kcal/mol. The effects of inhibitors, various solvents, inorganic salts, and swelling agents on graft yield were studied. A suitable kinetic scheme has been proposed and a rate equation has been derived. 相似文献
83.
In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the simultaneous determination of glimepiride and metformin in sustained release formulation. The separation was achieved on a Nucleosil 100-5SA column, 250 × 4.6 mm i.d., 5 μm using a mobile phase composed of 1.7 % ammonium dihydrogen phosphate buffer pH 3.0: acetonitrile (70:30 v/v).The instrumental settings were a flow rate of 1.0 ml min?1 and a detector wavelength of 230 nm. The retention time of glimepiride and metformin were 5.1 and 11.3, respectively. The developed method was validated in terms of specificity, sensitivity, linearity, range, accuracy, precision and ruggedness. The proposed method was successfully applied to the sustained release pharmaceutical dosage form for the simultaneous determination of glimepiride and metformin without any interference by excipients. 相似文献