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Ioffe VM Gorbenko GP Domanov YA Tatarets AL Patsenker LD Terpetsching EA Dyubko TS 《Journal of fluorescence》2006,16(1):47-52
The present study was undertaken to evaluate the sensitivity of newly synthesized squaraine dye 1 to the changes in lipid bilayer physical properties and compared it with the well-known dye 2. Partitioning of the dye 1 into lipid bilayer was found to be followed by significant increase of its fluorescence intensity and red-shift of emission
maximum, while intensity of the dye 2 fluorescence increased only slightly on going from aqueous to lipidic environment. This suggests that dye 1 is more sensitive to the changes in membrane properties as compared to dye 2. Partition coefficients of the dye 1 have been determined for the model membranes composed of zwitterionic phospholipid phosphatidylcholine (PC) and its mixtures
with positively charged detergent cetyltrimethylammonium bromide (CTAB), anionic phospholipid cardiolipin (CL), and sterol
(Chol). The spectral responses of the dye 1 in different liposome media proved to correlate with the increase of bilayer polarity induced by Chol and CL or its decrease
caused by CTAB. It was concluded that dye 1 can be used as fluorescent probe for examining membrane-related processes. 相似文献
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Galyna P. Gorbenko 《Journal of fluorescence》2011,21(3):945-951
Fluorescence spectroscopy is one of the most powerful tools for characterization of a multitude of biological processes. Of these, the phenomenon of protein oligomerization attracts especial interest due to its crucial role in the formation of fibrillar protein aggregates (amyloid fibrils) involved in ethiology of so-called protein misfolding diseases. It is becoming increasingly substantiated that protein fibrillization in vivo can be initiated and modulated at membrane-water interface. All steps of membrane-assisted fibrillogenesis, viz., protein adsorption onto lipid bilayer, structural transition of polypeptide chain into a highly aggregation-prone partially folded conformation, assembly of oligomeric nucleus from membrane-bound monomeric species and fiber elongation can be monitored with a mighty family of fluorescence-based techniques. Furthermore, the mechanisms behind cytotoxicity of prefibrillar protein oligomers are highly amenable to fluorescence analysis. The applications of fluorescence spectroscopy to monitoring protein oligomerization in a membrane environment are exemplified and some problems encountered in such kinds of studies are highlighted. 相似文献
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Paul Podsiadlo Galyna V. Krylova Arnaud Demortière Elena V. Shevchenko 《Journal of nanoparticle research》2011,13(1):15-32
In this article, we review the state-of-the-art in the preparation and characterization of multicomponent self-assembled superlattices of colloidal nanoparticles with core sizes in the range of 2–20 nm and interparticle spacing less than 2 nm down to intimate contact stemming from sintering. Several aspects of the field are discussed, including: structural organization, the role of particle size distribution, key interparticle forces at play, and methods of investigation of the structures. Contrary to the extensively studied colloidal crystals composed of microscale particles, the nanoparticles possess unique size-dependent properties, such as electronic, optical, or magnetic, which when combined into periodic structures can potentially lead to new collective states stemming from precise positioning of the nanocolloids. As such, we examine a number of emerging applications of this new class of metamaterials. Finally, we speculate on the potential impact of these materials, the new directions, and the challenges for the researchers. 相似文献
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Hülya Gizem Özkan Vanrajsinh Thakor Hong-Gui Xu Galyna Bila Prof. Dr. Rostyslav Bilyy Daria Bida Dr. Martin Böttcher Prof. Dr. Dimitrios Mougiakakos Dr. Rainer Tietze Prof. Dr. Andriy Mokhir 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(30):e202104420
Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are two weak points of cancer cells. Their simultaneous targeting is a valid therapeutic strategy to design highly potent anticancer drugs. The remaining challenge is to limit the drug effects to cancer cells without affecting normal ones. We have previously developed three aminoferrocene (AF)-based derivatives, which are activated in the presence of elevated levels of ROS present in cancer cells with formation of electron-rich compounds able to generate ROS and reduce mitochondrial membrane potential (MMP). All of them exhibit important drawbacks including either low efficacy or high unspecific toxicity that prevents their application in vivo up to date. Herein we describe unusual AF-derivatives lacking these drawbacks. These compounds act via an alternative mechanism: they are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells, but not normal cells and exhibit anticancer effect in vivo. 相似文献
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Alla G. Dyachenko Galyna G. Tsapyuk Snizhana V. Gaidai Olena V. Ischenko Tetiana M. Zakharova Galyna D. Il'nitskaya 《Molecular Crystals and Liquid Crystals》2020,701(1):91-97
AbstractIn this article, we present the preparation, characterization, and catalytic performance of bimetallic Co93Fe07 and Ni80Fe20 active mass loaded on synthetic nanodiamonds (SNDs) in the carbon dioxide (CO2) methanation. The pristine SNDs possessing a developed specific surface are thermally stable and inert to the reaction mixture of CO2 and dihydrogen. However, it is shown that 100% conversion of CO2 into methane can be reached at the lower temperature than that for a massive Co93Fe07 or Ni80Fe20 catalyst when 20?wt.% of the catalyst mass was loaded on the surface of SNDs. The catalytic activity of the prepared bimetallic/SNDs composites is estimated as the minimum temperature at the maximum conversion of CO2 at atmospheric pressure: it is 325 and 290?°C for Co93Fe07/SNDs and Ni80Fe20/SNDs, respectively. Thermal desorption studies showed that the methanation over Co-Fe/SNDs and Ni-Fe/SNDs catalysts run through the stage of CO2 dissociation into carbon and oxygen atoms and their subsequent interaction with hydrogen to form methane and water molecules. Scanning electron microscopy studies have shown that the presence of transition metal-rich sites on the surface of the carrier contributes to the improvement of efficiency of the Ni80Fe20 catalyst action. 相似文献