Ferrocene‐modified thiopyrimidines: synthesis,enantiomeric resolution,antitumor activity

Ferrocenylalkyl thiopyrimidines ( 6a–d to 9a–d ) were prepared via the reaction of the α‐(hydroxy)alkyl ferrocenes, FcCHR(OH) ( 1a–d ; Fc = ferrocenyl; R = H, Me, Et, Ph), with 2‐thiopyrimidines ( 2 – 5 ) in acetone at room temperature in the presence of TFA, yielding 50–95%. The resulting enantiomers were resolved using HPLC on modified cellulose as chiral selector. The antitumor activities of S‐ferrocenylethyl 2‐thiopyrimidine ( 6b ) against two murine solid tumor models, carcinoma 755 (Ca755) and Lewis lung carcinoma (LLC) were evaluated in vivo. The strong antitumor effect of compound 6b on Ca755 and LLC was demonstrated. The index of tumor growth inhibition on Ca755 equaled 95% in comparison with control. Copyright © 2010 John Wiley & Sons, Ltd.     

(4+2) Dimerization of imides of arylmaleic acids in the presence of the 3,5-dimethyl-1H-pyrazole and 2,6-lutidine

Imides of arylmaleic acids in the presence of 3,5-dimethyl-1H-pyrazole underwent (4+2) dimerization under heating in chlorobenzene within 24 h to afford 1,2,3,3a,3b,4,5,6,6a,10b-decahydrobenzo[e]pyrrolo[3,4-g]isoindole-1,3,4,6-tetraones in good yields. It was established that during the heating of imides of arylmaleic acid in 2,6-lutidine at 100 °C the (4+2) dimerization products containing a lutidine fragment are obtained.     

Phase transitions and molecular properties of new divinyl and diepoxy compounds

The aim of this paper is to compare some physical properties of six new divinyl and diepoxy compounds. The compounds differ in the length of the rigid central segments. Optical observations and differential scanning calorimetry confirmed the existence of a mesophase in five compounds and enabled the determination of the phase transition temperatures. The wide angle X-ray scattering (WAXS) measurements of samples aligned in a magnetic field and the optical observations allowed the identification of the mesophase types. In four compounds a nematic mesophase was detected during both heating and cooling. In one case two higher ordered phases were observed during cooling. The analysis of WAXS images and the positions and shapes of the scattering intensity peaks suggests a smectic B-crystal E transition. Using the data obtained in WAXS measurements carried out in the nematic phase, the lengths of the molecules and the average nearest neighbour distances were estimated. The average intermolecular distances and the layer spacings were also estimated for the SmB and E phases. The lengths of the molecules were also calculated by means of theoretical ab initio methods. The results obtained are in very good agreement with the experimental data.     

Removal of hydrogen sulfide from methane in a barrier discharge

Plasma Chemistry and Plasma Processing - A process of removal of hydrogen sulfide from methane in a barrier discharge is investigated. A complete removal of hydrogen sulfide is achieved in one pass...     

Biochemical fractionation and cellular distribution of americium and plutonium in the biomass of freshwater macrophytes

Accumulation of americium (²⁴¹Am) and plutonium (^238,242Pu) and their distribution in cell compartments and biochemical components of the biomass of freshwater aquatic plants Elodea canadensis, Ceratophyllum demersum and Myrioplyllum spicatum and aquatic moss Fontinalis antipyretica have been investigated in laboratory experiments. Americium and plutonium taken up from water by Elodea canadensis apical shoots were mainly absorbed by structural components of plant cells (90% for ²⁴¹Am; 89% for ²³⁸Pu and 82–87% for ²⁴²Pu). About 10–18% of isotope activity was recorded in the cytosol fraction. The major concentration (76–92%) of americium was bound to cell wall cellulose-like polysaccharides of Elodea canadensis, Myriophyllum spicatum, Ceratophyllum demersum and Fontinalis antipyretica, 8–24% of americium activity was registered in the fraction of proteins and carbohydrates, and just a minor concentration (<1%) in the lipid fraction. The distribution of plutonium in the biomass fractions of Elodea was similar to that of americium. Hence, americium and plutonium had the highest affinity to cellulose-like polysaccharides of cell walls of freshwater submerged macrophytes.     

Formation of the paramagletic Ni(I) π-allyl complex in the Ni(allyl)2 - (2,6-diisopropylphenyl)diazabutadiene system

It has been shown that the reaction of Ni(allyl)₂ with (2,6-diisopropylphenyl)diazabutadiene gives the imino-amide Ni complex (1). The imino-amide moiety of this complex undergoes some complicated rearrangements resulting in spontaneous formation of a paramagnetic π-allyl Ni(I) complex. Nickel complexes formed in the system have been studied with ESR, FTIR, 2D NMR, and mass spectrometry. The structure of complex 1 was studied with X-ray diffraction.     

Synthesis and structure of nitrocyclohexenylcarboxylates

The diene condensation of 3-nitro- and 3-bromo-3-nitroacrylates with 2,3-dimethyl-1,3-butadiene and isoprene obtained under the reaction condition from 3-methyl-3-thiolene-1,1-dioxide was investigated. The formed 6-nitro-3-cyclohexenylcarboxylates were subjected to the intramolecular transformation (dehydration and dehydrohalogenation) to give the corresponding nitrocyclohexadienyl- and arylcarboxylates. The structure of the obtained compounds was established from the IR, ¹H NMR spectra and independent synthesis.