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101.
G. Tiana M.H. Jensen K. Sneppen 《The European Physical Journal B - Condensed Matter and Complex Systems》2002,29(1):135-140
A feedback mechanism that involves the proteins p53 and mdm2, induces cell death as a controlled response to severe DNA damage.
A minimal model for this mechanism demonstrates that the response may be dynamic and connected with the time needed to translate
the mdm2 protein. The response takes place if the dissociation constant k between p53 and mdm2 varies from its normal value. Although it is widely believed that it is an increase in k that triggers the response, we show that the experimental behaviour is better described by a decrease in the dissociation
constant. The response is quite robust upon changes in the parameters of the system, as required by any control mechanism,
except for few weak points, which could be connected with the onset of cancer.
Received 8 May 2002 / Received in final form 9 July 2002 Published online 17 September 2002 相似文献
102.
We prove that the diffusion semigroups generated by the second order differential ultraspherical (Gegenbauer) operator are pseudomeasure operators. 相似文献
103.
Hellweg T. Schemmel S. Rother G. Brlet A. Eckerlebe H. Findenegg G.H. 《The European physical journal. E, Soft matter》2003,12(1):1-4
The European Physical Journal E - The temperature-induced microphase separation of the binary liquid system iso-butyric acid+heavy water (iBA + D2O) in a mesoporous silica glass (CPG-10-75) of... 相似文献
104.
JETP Letters - The problem of storing ultracold neutrons over a plane magnetic mirror in the presence of gravity is considered. For neutrons with a definite polarization, the sum of the magnetic... 相似文献
105.
I. V. Denisova O. A. Ladyzhenskaya G. A. Seregin N. N. Uraltseva E. V. Frolova 《Journal of Mathematical Sciences》2005,130(4):4775-4779
Bibliography: 42 titles.__________Translated from Zapiski Nauchnykh Seminarov POMI, Vol. 306, 2003, pp. 7–15. 相似文献
106.
107.
G.P. Romanelli D. Bennardi D.M. Ruiz G. Baronetti H.J. Thomas 《Tetrahedron letters》2004,45(48):8935-8939
Substituted coumarins are synthesized from phenols and β-ketoesters by the Pechmann reaction, using a Wells-Dawson heteropolyacid (H6P2W18O62·24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130 °C temperature and as little as 1 mol % of Wells-Dawson acid, obtaining good to excellent yields of coumarins. The catalyst showed to be reusable with no differences in the yields. The results are compared with those of the reactions performed in toluene solution. The presented synthetic procedure is a convenient, clean and fast alternative for synthesizing 4-substituted coumarins (17 examples). 相似文献
108.
G. Tóth 《Journal of Radioanalytical and Nuclear Chemistry》1989,137(4):259-264
The distribution of mono- poly- and unlabelled protein molecules in the radiolabelling mixture was calculated from probability point of view as a function of the radioiodine/protein ratio. 相似文献
109.
L. Ya. Yukel'son I. I. Parilis G. L. Bussel' D. Kh. Khamidov 《Chemistry of Natural Compounds》1989,25(6):698-704
On the basis of a computer analysis of four classes of toxic polypeptides, generalized primary structures of each class have been obtained which can be used for planning the synthesis of biologically active compounds. 相似文献
110.
The precision of intensity modulated fiber optic sensor systems mainly is restricted by the attenuation characteristics of the analog fiber optical data link. Special encoding and referencing schemes are used to overcome this data link dependence. In this paper encoding and referencing principles for optical sensors are outlined and compared. Especially the two wavelengths referencing and the optical delay line processing techniques are discussed in more detail and results are presented. 相似文献