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41.
5-O-(4-[125 I]Iodobenzyl)-L-ascorbic acid: electrophilic radioiodination and biodistribution in mice
Kim J Kino T Kato H Yamamoto F Sano K Mukai T Maeda M 《Chemical & pharmaceutical bulletin》2012,60(2):235-240
As a part of our efforts to develop potential imaging agents for ascorbate bioactivity, 5-O-(4-[(125)I]iodobenzyl)-L-ascorbic acid ([(125)I]1) was prepared through a two-step sequence which involved radioiodo-destannylation of a protected tributylstannyl precursor 6, followed by hydrolysis in acidic methanol of the protecting groups in 61% overall radiochemical yield, with a radiochemical purity of over 98% and a specific activity of more than 15.4?GBq/μmol. Tissue distribution of [(125)I]1 in tumor-bearing mice showed signs of distribution profiles similar to the reported results for 6-deoxy-6-[(18)F]fluoro-L-ascorbic (6-(18)FAsA) acid and 6-deoxy-6-[(131)I]iodo-L-ascorbic acid (6-(131)IAsA) but with notable differences in the adrenal glands, in which considerably lower uptake of radioactivity and rapid clearance with time were observed. Pretreatment of mice with a known inhibitor of ascorbate transport, sulfinpyrazone, did not produce any significant change in the adrenal uptake of radioactivity after injection of [(125)I]1 compared to the control, suggesting that uptake in the adrenal glands is independent of the sodium-dependent vitamin C transporter 2 transport mechanism. Introduction of a bulky substituent at C-5 on AsA, such as an iodobenzyloxy group, may not be suitable for the design of analogs that may still be able to maintain characteristic distribution properties in vivo seen with AsA itself. 相似文献
42.
Xiaoxi Xu Schein J. Niansheng Qi Prasad R.R. Krishnan M. Fumihiko T. Tantawi S.G. 《IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society》2001,29(1):85-92
The use of a diamond RF switch for super-highpower microwave/millimeter wave generation has been evaluated. An X-band chemical vapor deposition (CVD) diamond window package was theoretically analyzed, designed, and built. Thirty-eight percent of an injected microwave signal with a frequency of 11.424 GHz was reflected from a 100-μm thick, 22-mm-diameter CVD diamond window when activated by a 160-mJ, 266-nm Nd:YAG laser. The details of the CVD diamond window design and experimental results are presented. The results have high application potential for building super-high-power microwave systems 相似文献
43.
A new MC simulation method is proposed for the controlled/living radical polymerization in a dispersed medium, assuming an ideal miniemulsion system. This tool is used to consider the effects of particle size on the polymerization rates and the molecular weight distributions. For NMP, the polymerization kinetics are basically governed by two conflicting factors, (i) the confined space effect that promotes the coupling reaction between a radical and a trapping agent and (ii) the isolation effect of radicals into different particles that suppresses the overall frequency of bimolecular termination. For RAFT polymerization, a significant rate enhancement by reducing the particle size could be observed only for the systems with fast fragmentation of adduct radicals.
44.
GUOLu ZHAOEn-Guang SAKATAFumihiko 《理论物理通讯》2003,40(5):573-576
Ground-state properties of C, O, and Ne isotopes are described in the framework of Hartree-Fock-Bogoliubov theory with density-dependent finite-range Gogny interaction D1S. We include all the contributions to the Hartree-Fock and pairing feld arising from Gogny and Coulomb interaction as well as the center of mass correction in the numerical calcu/ations. These ground-state properties of C, O, and Ne isotopes are compared with available experimental results, Hartree-Fock plus BCS, shell model and relativistic Hartree--Bogoliubov calculations. The agreement between experiments and our theoretical results is pretty well. The predicted drip-line is dependent strongly on the model and effective interaction due to their sensitivity to various theoretical details. The calculations predict no evidence for halo structure predicted for C,O, and Ne isotopes in a previous RHB study. 相似文献
45.
We consider the localized region of the Anderson model and study the distribution of eigenfunctions simultaneously in space
and energy. In a natural scaling limit, we prove convergence to a Poisson process. This provides a counterpoint to recent
work, [9], which proves repulsion of the localization centres in a subtly different regime.
Submitted: December 12, 2005; Revised: April 22, 2006; Accepted: May 3, 2006 相似文献
46.
Hidetoshi Sekiguchi Atsushi Kanzawa Takuya Honda 《Plasma Chemistry and Plasma Processing》1989,9(2):257-275
Effects of the thermal quenching process in the synthesis of NO and the decomposition of CO2 were studied using a thermal argon plasma and different-i.d. cooling tubes. Four tubes of different i.d.'s were used to change the cooling rate. The conversions obtained in both reactions increased with decreasing quenching tube diameter. Furthermore, the concept of quenching temperature was introduced. This temperature was obtained from two time constants of reaction and cooling rate. The conversions into CO can be estimated in a similar manner to the NO synthesis with a proper modification for radicals which remain at high concentrations at the quenching temperature. 相似文献
47.
Yozo Miura Kunihiko Inui Fumihiko Yamaguchi Makoto Inoue Yoshio Tek? Takeji Takui Koichi Itoh 《Journal of polymer science. Part A, Polymer chemistry》1992,30(6):959-966
The present article describes the synthesis and magnetic properties of poly(phenylacetylene) ( 3 ) with pi-toporegulated pendant stable 4,4,5,5-tetramethylimidazolin-3-oxide-1-yloxyl radicals topologically participating in the pi-conjugated system of poly(phenylacetylene). Polyradical 3 was prepared by the condensation reaction of poly(p-ethynylbenzaldehyde) with 2,3-bis(hydroxylamino)-2,3-dimethylbutane followed by oxidation with lead dioxide. The spin concentration of 3 determined by the ESR spectroscopic method was 1.1 × 1021 spins/g. This value approximately corresponds to 0.5 unpaired electron spin per the repeating unit. A powder ESR spectrum of 3 gave a 100% Lorentzian single line showing spin-exchange narrowing. The vibrating sample magnetometer (VSM) measurement of 3 afforded a straight line with a positive slope, suggesting that 3 has predominant paramagnetic properties within an experimental error. 相似文献
48.
Rivkin A Yoshimura F Gabarda AE Chou TC Dong H Tong WP Danishefsky SJ 《Journal of the American Chemical Society》2003,125(10):2899-2901
The total synthesis of a family of (E)-9,10-dehydro derivatives of epothilone D (i.e., 12,13-desoxyepothilone B) is described. The route is particularly concise and amenable to production of new congeners. Furthermore, the chemistry described herein constitutes a major simplification in the total synthesis of EpoD, which is in human clinical trials. This new family of epothilones shows major advantages in terms of their potency and pharmacostability relative to the wild-type saturated analogues in the D series. From the perspective of compound availability through synthesis, potency, and pharmacokinetic properties, these compounds could well warrant advancement to clinical evaluation in humans. 相似文献
49.
Low-temperature synthesis of niobium oxide nanoparticles from peroxo niobic acid sol 总被引:1,自引:0,他引:1
Uekawa N Kudo T Mori F Wu YJ Kakegawa K 《Journal of colloid and interface science》2003,264(2):378-384
A peroxo niobic acid sol was prepared by peptization of the niobic acid precipitate (Nb2O5.nH2O) with a H2O2 aqueous solution. Crystallized Nb2O5 nanoparticles and niobic acid nanoparticles were obtained by heating the peroxo niobic acid sol. When peroxo niobic acid sol prepared by peptization of the niobic acid precipitate ([NH3]=0.3 mol/l) was heated at 348 K for 1 week, Nb2O5 nanoparticles with a diameter of 4.5 nm and a S(BET) of 275 m2/g were obtained. When peroxo niobic acid sol prepared by peptization of the niobic acid precipitate ([NH3]=1 mol/l) was heated at 348 K for 1 week, niobic acid nanoparticles with a diameter of less than 2 nm were obtained. The pore structure and degree of crystallinity of the nanoparticles prepared by heating the peroxo niobic acid sol greatly depended on the concentration of the ammonia solution used for preparing the niobic acid precipitate. 相似文献
50.
Shoji Takigami Fumihiko Kobayashi Yoshio Nakamura 《Journal of polymer science. Part A, Polymer chemistry》1987,25(1):63-75
Nylon 6 film and acrylic acid grafted nylon 6 (GN) membrances were reacted with paraformaldehyde and lactic acid in the presence of acid catalysts. Decrystallized nylon 6 (DN) and decrystallized grafted nylon 6 (DGN) membranes were thus obtained. The cross sections of GN and DGN membranes were observed by a transmission electron microscope. Branch poly(acrylic acid) penetrated toward the center of the membrane and deposited homogeneously within the membrane as the extent of grafting exceeded about 100%. The reverse osmosis of DN and DGN membranes was investigated. The water permeability through the membranes was improved by the decrystallization reaction. DGN membranes with more than 100% grafting show high values of the salt rejection (Rs) as compared with DN and DGN membranes with about 50% grafting, especially at the region of the high hydraulic permeability coefficient of water (K). The relationships among Rs, K, and the volume fraction of water (H) are discussed by considering the results of the decrystallization reaction and electron microscopy. 相似文献