Extracorporeal cardiac shock wave therapy for ischemic heart disease

Prognosis of severe ischemic heart disease with no indication of percutaneous coronary intervention or coronary artery bypass grafting still remains poor. Extracorporeal shock wave therapy was introduced for medical therapy more than 20 years ago to break up kidney stones. We have demonstrated that extracorporeal cardiac shock wave therapy at a low level of ~10% of energy density that used for urinary lithotripsy treatment, effectively induces coronary angiogenesis and improves myocardial ischemia in a porcine model of chronic myocardial ischemia in vivo. On the basis of the promising results in animal studies, we have recently developed a new, non-invasive angiogenic therapy with low-energy shock waves for ischemic heart disease. Our extracorporeal cardiac shock wave therapy improved symptoms and myocardial ischemia in patients with severe coronary artery disease. These beneficial effects of the shock wave therapy persisted for at least 12 months. Importantly, no procedural complications or adverse effects were noted. These results indicate that our extracorporeal cardiac shock wave therapy is an effective and non-invasive treatment for ischemic heart disease. To further confirm the usefulness and safety of our SW therapy, we are currently conducting the second clinical trial in a randomized and placebo-controlled manner.      

Global time evolution of viscous vortex rings

This article gives an overview of growing knowledge of translation speed of an axisymmetric vortex ring, with focus on the influence of viscosity. Helmholtz–Lamb’s method provides a shortcut to manipulate the translation speed at both small and large Reynolds number, for a vortex ring starting from an infinitely thin core. The resulting asymptotics significantly improve Saffman’s formula (1970) and give closer lower and upper bounds on translation speed in an early stage. At large Reynolds numbers, Kelvin–Benjamin’s kinematic variational principle achieves a further simplification. At small Reynolds numbers, the whole life of a vortex ring is available from the vorticity obeying the Stokes equations, which is closely fitted, over a long time, by Saffman’s second formula.     

Intramolecular double michael reaction III Stereoselective chiral synthesis of atisiran-15-one

Atisiran-15-one (5) was stereoselectively synthesized starting from the ketone (10) through the intramolecular double Michael reaction.     

A novel synthesis of benzo- and indolo[a]quinolizidines by intramolecular diels-alder reaction of l-azadienes

Intramolecular Diels-Alder reaction of l-azadienes was conducted by heating the α,β-unsaturated amides (2a ～ d and 6) in the presence of trimethyl- chlorosilane, triethylamine and zinc chloride to give benzo- and indolo[a]- quinolizidines (5a ～ e and 7).     

ABSORPTION POLARIZATION PROPERTIES OF LIGHT-ADAPTED BACTERIORHODOPSIN IN THE 266–620nm REGION

Abstract— Using the method of polarized photochemistry, the polarization of the first daughter (K₆₁₀) in the photocycle of light-adapted bacteriorhodopsin (bR₅₇₀) is determined relative to the polarization of the photolysis pulse for different absorption regions of bR₅₇₀. The results are discussed in terms of recent spectroscopic assignments of bR₅₇₀, and in the 310–266 nm region, in terms of energy transfer processes between the apoprotein and the retinal.     

Studies on the syntheses of heterocyclic compounds—DXXII : Photolytic synthesis of 1,12-dihydroxy-2,10,11- trimethoxyhomoaporphine

Photolysis of 1-(2-bromo-3-hydroxy-4,5-(dimethoxyphenethyl)-1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methylisoquinoline (8) gave 4,5,6,6a-tetrahydro-1,12-dihydroxy-2,10,11-trimethoxy-6-methylhomoaporphine (7), which is identical with the alkaloid CC-24 isolated from Cholchicum cornigerum.     

Studies on the syntheses of heterocyclic compounds. Part CDXCVII. Total syntheses of (±)-cryptaustoline and (±)-thaliporphine by the benzyne reaction

The indisputable benzyne reaction of 1-(5-bromo-3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-7-hydroxy-6-metlioxy-2-methylisoquinoline (II) with sodium amide in liquid ammonia afforded the following compounds, (±)-cryptaustoline iodide (VI), (±)-thaliporphine (VIII), 1 -(3,4-dimeth-oxybenzyl)- (III), and 1 -(2-amino-4,5-dimethoxybenzyl)-l,2,3,4-tetrahydro-7-hydroxy-6-meth-oxy-2-methylisoquinoline (IV).     

Studies on the syntheses of heterocyclic compounds. Part CCCXV erythrinan and related compounds. II . An alternative synthesis of cis-16-hydroxy-15-methoxyerythrinan-8-one and its mass spectrum

Phenolic cyclization of 2-ethoxycarbonylmethylidenecyclohexanone (IV) with 3-hydroxy-4-methoxyphenethylamine (V) were performed in the process of finding a synthetic approach to dihydroerysolidine (I). Thus, 16-hydroxy-15-methoxyerythrinan-6-ene-8-one (VI) and 16-hydroxy-15-methoxyerythrinan-7-ene-8-one (VII) were synthesized, both of which were hydrogenated in the presence of Adams platinum to give the same product (XI). Furthermore, on the basis of the mass spectra of XI and XII, these compounds were assumed to be stereoisomeric at the C₅- and C₆-positions.     

Luminescent palladium complexes containing thioamide-based SCS pincer ligands

Thioamide-based tridentate ligands, 1,3-benzenedicarbothioamides (1a-c), were used to afford pincer palladium(II) complexes (Pd(1-H)Cl, 2a-c) with η³-S,C,S type coordination. The complexes exhibit strong emission in a glassy frozen state as well as in the solid state. The decay lifetime of the emission from the complexes is in a range of 8-9 × 10⁻⁵ s, which is indicative of phosphorescent emission.