Phase contrast imaging of preclinical portal vein embolization with CO2 microbubbles

Preoperative portal vein embolization (PVE) is employed clinically to avoid postoperative liver insufficiency. Animal models are usually used to study PVE in terms of mechanisms and pathophysiological changes. PVE is formerly monitored by conventional absorption contrast imaging (ACI) with iodine contrast agent. However, the side effects induced by iodine can give rise to animal damage and death. In this study, the feasibility of using phase contrast imaging (PCI) to show PVE using homemade CO₂ microbubbles in living rats has been investigated. CO₂ gas was first formed from the reaction between citric acid and sodium bicarbonate. The CO₂ gas was then encapsulated by egg white to fabricate CO₂ microbubbles. ACI and PCI of CO₂ microbubbles were performed and compared in vitro. An additional increase in contrast was detected in PCI. PCI showed that CO₂ microbubbles gradually dissolved over time, and the remaining CO₂ microbubbles became larger. By PCI, the CO₂ microbubbles were found to have certain stability, suggesting their potential use as embolic agents. CO₂ microbubbles were injected into the main portal trunk to perform PVE in living rats. PCI exploited the differences in the refractive index and facilitated clear visualization of the PVE after the injection of CO₂ microbubbles. Findings from this study suggest that homemade CO₂ microbubbles‐based PCI is a novel modality for preclinical PVE research.     

反相离子对高效液相色谱法测定动物血浆中的恩诺沙星及其代谢物

建立了用反相离子对ＨＰＬＣ测定动物血浆中恩诺沙星（ＥＲＦＸ）及其代谢产物环丙沙星（ＣＰＦＸ）浓度的方法。血浆中药物用二氯甲烷萃取,选用ＯＤＳ柱,甲醇－四丁基氢氧化铵溶液为流动相,吡哌酸（ＰＰＡ）作内标,检测波长２７２ｎｍ。方法简便、快速、灵敏、准确,适用于ＥＲＦＸ及其代谢物ＣＰＦＸ血药浓度的测定和药代动力学研究。并首次测定了黄牛血浆中的ＥＲＦＸ和ＣＰＦＸ。     

有机低分子凝胶因子

糖苷、甾核、氨基酸等类型结构化合物是近年来有机低分子凝胶因子的研究重点,联（并）苯、有机金属化合物以及二元凝胶体系等方面有了新的拓展。本文综述了2000年以来有机低分子凝胶因子主要结构类型、表征方法和应用的研究进展,分析了凝胶因子在敏感性材料、无机纳米材料、固体燃料、固体电解质、药物控释等方面的应用,展望了其在分子识别、光电材料、半导体材料、生物催化等方面的潜在应用。     

Space–Time Method for Detonation Problems with Finite-rate Chemical Kinetics

The space–time conservation element and solution element (CE/SE) method originally developed for non-reacting flows is extended to accommodate finite-rate chemical kinetics for multi-component systems. The model directly treats the complete conservation equations of mass, momentum, energy, and species concentrations. A subtime-step integration technique is established to handle the stiff chemical source terms in the formulation. In addition, a local grid refinement algorithm within the framework of the CE/SE method is incorporated to enhance the flow resolution in areas of interest. The capability and accuracy of the resultant scheme are validated against several detonation problems, including shock-induced detonation with detailed chemical kinetics and multi-dimensional detonation initiation and propagation.     

复合材料组分性能随机性识别的克里金随机分析方法

建立非均匀材料宏观力学性能与微结构参数之间的定量关系一直是人们所关心的问题,利用材料微结构参数和组分性能预报复合材料宏观力学性能,已经取得了很大的进展,然而已知复合材料宏观性能,如何开展组分性能的随机识别,目前的研究工作还不多见.论文考虑了复合材料的随机性,在已知复合材料宏观有效性能的随机性条件下,采用克里金随机分析方法,对复合材料组分性能的随机性进行识别,通过单向纤维复合材料的宏观有效性能的随机性,计算得到了纤维弹性模量的均值与方差,证明了该方法的有效性.     

双重分数傅里叶变换计算全息

提出了双重分数傅里叶变换计算全息，在这种方法中，将两个图像的信息分别经不同阶的分数傅里叶变换后，记录在同一张分数傅里叶变换计算全息图上，它需要两个特定的分数傅里叶变换系统才能再现出所记录的图像信息，利用其再现方式的特殊性，可制成一种新的安全认证系统。     

采用非线性相位拟合法设计长焦深透镜

针对惯性约束聚变(ICF)激光等离子体诊断系统应用的需求,提出一种采用非线性相位拟合法设计单透镜代替理想对数轴锥镜的方法。对所要得到的球面透镜与理想对数轴锥镜的相位进行拟合,求解得出所需要的球面透镜参量。设计了用于激光等离子体诊断系统的长焦深透镜,并对透镜的焦深、轴向光场均匀性、横向均匀性、焦斑旁瓣等指标进行分析。数值分析结果表明,长焦深透镜具有与理想对数轴锥镜相同的相位分布,焦深、轴向光场均匀性、横向均匀性、焦斑旁瓣均符合设计要求,验证了非线性相位拟合法的正确性。     

Chemical Modification of the sp-Hybridized Carbon Atoms of Graphdiyne by Using Organic Sulfur

Here, a new approach to further improve graphdiyne (GDY) based materials by using benzyl disulfide (BDS) as the sulfur source is demonstrated. The S radicals, generated from the homolysis of BDS, can react with the acetylenic bonds and be well confined in the triangle-like pores of GDY, forming S-GDY. The as-prepared S-GDY, which possesses numerous heteroatom defects and active sites, is suitable for applications in many electronic devices, such as lithium ion batteries (LIBs). As expected, the assembled LIBs based on S-GDY displayed improved electrochemical properties, including larger capacity and superior rate capability.     

Periodic,almost periodic and chaotic motions of forced self-sustained oscillators

Steady motions of the Van der Pol oscillator and an oscillator with hysteresis are studied numerically in this paper. Some features of periodic, almost periodic and chaotic motions of forced self-sustained oscillators are investigated. This paper has been presented at the ICTAM XVI Lyngby.