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171.
Inside Back Cover: Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification (Angew. Chem. Int. Ed. 27/2018)
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172.
Molecular Firefighting—How Modern Phosphorus Chemistry Can Help Solve the Challenge of Flame Retardancy
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Dr. Maria M. Velencoso M. Sc. Alexander Battig M. Sc. Jens C. Markwart Priv.‐Doz. Dr. Bernhard Schartel Priv.‐Doz. Dr. Frederik R. Wurm 《Angewandte Chemie (International ed. in English)》2018,57(33):10450-10467
The ubiquity of polymeric materials in daily life comes with an increased fire risk, and sustained research into efficient flame retardants is key to ensuring the safety of the populace and material goods from accidental fires. Phosphorus, a versatile and effective element for use in flame retardants, has the potential to supersede the halogenated variants that are still widely used today: current formulations employ a variety of modes of action and methods of implementation, as additives or as reactants, to solve the task of developing flame‐retarding polymeric materials. Phosphorus‐based flame retardants can act in both the gas and condensed phase during a fire. This Review investigates how current phosphorus chemistry helps in reducing the flammability of polymers, and addresses the future of sustainable, efficient, and safe phosphorus‐based flame‐retardants from renewable sources. 相似文献
173.
Johanna Simon Thomas Wolf Katja Klein Prof. Dr. Katharina Landfester Priv.‐Doz. Dr. Frederik R. Wurm Prof. Dr. Volker Mailänder 《Angewandte Chemie (International ed. in English)》2018,57(19):5548-5553
Increasing the plasma half‐life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half‐life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester‐coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake. 相似文献
174.
Electronic Energy Spectrum of Two-Dimensional Solids and a Chain of C Atoms from a Quantum Network Model 总被引:1,自引:0,他引:1
Claudio Amovilli Frederik E. Leys Norman H. March 《Journal of mathematical chemistry》2004,36(2):93-112
The aim of this study is to explain how a quantum network can be used as simple model to calculate complex band structures. The paper contains an introduction, a mathematical exposure of the method, and applications to graphene, boron nitride, and polyacetylene chains. Using a quantum network is a simple, intuitive, and, yet, rather accurate way to obtain a band structure for a complex material. One focus here is to invoke physical and chemical intuition to construct the effective one-body potential along the wires of a quantum network. 相似文献
175.
Swapping Interface Contacts in the Homodimeric tRNA‐Guanine Transglycosylase: An Option for Functional Regulation
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Dr. Frederik Rainer Ehrmann Jorna Kalim Dr. Toni Pfaffeneder Dr. Bruno Bernet Dr. Christoph Hohn Dr. Elisabeth Schäfer Dr. Thomas Botzanowski Dr. Sarah Cianférani Prof. Dr. Andreas Heine Prof. Dr. Klaus Reuter Prof. Dr. François Diederich Prof. Dr. Gerhard Klebe 《Angewandte Chemie (International ed. in English)》2018,57(32):10085-10090
The enzyme tRNA‐guanine transglycosylase, a target to fight Shigellosis, recognizes tRNA only as a homodimer and performs full nucleobase exchange at the wobble position. Active‐site inhibitors block the enzyme function by competitively replacing tRNA. In solution, the wild‐type homodimer dissociates only marginally, whereas mutated variants show substantial monomerization in solution. Surprisingly, one inhibitor transforms the protein into a twisted state, whereby one monomer unit rotates by approximately 130°. In this altered geometry, the enzyme is no longer capable of binding and processing tRNA. Three sugar‐type inhibitors have been designed and synthesized, which bind to the protein in either the functionally competent or twisted inactive state. They crystallize with the enzyme side‐by‐side under identical conditions from the same crystallization well. Possibly, the twisted inactive form corresponds to a resting state of the enzyme, important for its functional regulation. 相似文献
176.
Frederik Neuhaus Dr. Dennis Mueller Dr. Radu Tanasescu Dr. Sandor Balog Prof.Dr. Takashi Ishikawa Prof. Dr. Gerald Brezesinski Prof. Dr. Andreas Zumbuehl 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(23):6615-6618
Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2-diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges. These conditions are optimized in the geometrical structure of a cube. Surprisingly, the lateral surface pressure in the membrane is only one third of the value typically assumed for a bilayer membrane, questioning a long-standing rule-of-thumb. 相似文献
177.
178.
In search of analogs of 1α,25-dihydroxyvitamin D3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way. 相似文献
179.
Frederik Detobel Hamed Eghbali Selm De Bruyne Herman Terryn Han Gardeniers Gert Desmet 《Journal of chromatography. A》2009,1216(44):7360-7367
We report on the synthesis of siloxane-based monoliths in the presence of a two-dimensional, perfectly ordered array of micro-pillars. Both methyltrimethoxysilane- and tetramethoxysilane-based monoliths were considered. The obtained structures were analyzed using scanning-electron microscopy and can be explained from the general theory of surface-directed phase separation in confined spaces. The formed structures are to a large extent nearly exclusively determined by the ratio between the bulk domain size of the monolith on the one hand and the distance between the micro-pillars on the other hand. When this ratio is small, the presence of the pillars has nearly no effect on the morphology of the produced monoliths. However, when the ratio approaches unity and ascends above it, some new types of monolith morphologies are induced, two of which appear to have interesting properties for use as novel chromatographic supports. One of these structures (obtained when the domain size/inter-pillar distance ratio is around unity) is a 3D network of linear interconnections between the pillars, organized such that all skeleton branches are oriented perpendicular to the micro-pillar surface. A second interesting structure is obtained at even higher values of the domain size/inter-pillar distance ratio. In this case, each individual micro-pillar is uniformly coated with a mesoporous shell. 相似文献
180.