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61.
In this paper we introduce broccoli curves, certain plane tropical curves of genus zero related to real algebraic curves. The numbers of these broccoli curves through given points are independent of the chosen points — for arbitrary choices of the directions of the ends of the curves, possibly with higher weights, and also if some of the ends are fixed. In the toric Del Pezzo case we show that these broccoli invariants are equal to the Welschinger invariants (with real and complex conjugate point conditions), thus providing a proof of the independence of Welschinger invariants of the point conditions within tropical geometry. The general case gives rise to a tropical Caporaso–Harris formula for broccoli curves which suffices to compute all Welschinger invariants of the plane. 相似文献
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Claudia J. Diehl Thomas Scattolin Ulli Englert Franziska Schoenebeck 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(1):217-221
While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air‐stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C?I over C?Br bonds in C?C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd0 and PdI‐PdI catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible. 相似文献
63.
Guillaume Magnin Jamie Clifton Franziska Schoenebeck 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(30):10285-10289
While current M0/MII based polymerization strategies largely focus on fine‐tuning the catalyst, reagents and conditions for each and every monomer, this report discloses a single method that allows access to a variety of different conjugated polymers within seconds at room temperature. Key to this privileged reactivity is an air‐ and moisture stable dinuclear PdI catalyst. The method is operationally simple, robust and tolerant to air. 相似文献
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Lena Quambusch Ina Landel Laura Depta Jrn Weisner Niklas Uhlenbrock Matthias P. Müller Franziska Glanemann Kristina Althoff Jens T. Siveke Daniel Rauh 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(52):18999-19005
Isoforms of protein kinase Akt are involved in essential processes including cell proliferation, survival, and metabolism. However, their individual roles in health and disease have not been thoroughly evaluated. Thus, there is an urgent need for perturbation studies, preferably mediated by highly selective bioactive small molecules. Herein, we present a structure‐guided approach for the design of structurally diverse and pharmacologically beneficial covalent‐allosteric modifiers, which enabled an investigation of the isoform‐specific preferences and the important residues within the allosteric site of the different isoforms. The biochemical, cellular, and structural evaluations revealed interactions responsible for the selective binding profiles. The isoform‐selective covalent‐allosteric Akt inhibitors that emerged from this approach showed a conclusive structure–activity relationship and broke ground in the development of selective probes to delineate the isoform‐specific functions of Akt kinases. 相似文献
65.
Sophia Boden Franziska Reise Jessica Kania Thisbe K. Lindhorst Laura Hartmann 《Macromolecular bioscience》2019,19(4)
This study investigates the influence of an increasingly hydrophobic backbone of multivalent glycomimetics based on sequence‐defined oligo(amidoamines) on their resulting affinity toward bacterial lectins. Glycomacromolecules are obtained by stepwise assembly of tailor‐made building blocks on solid support, using both hydrophobic aliphatic and aromatic building blocks to enable a gradual change in hydrophobicity of the backbone. Their binding behavior toward model lectin Concanavalin A (ConA) is evaluated using isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) showing higher affinities for glycomacromolecules with higher content of hydrophobic and aromatic moieties in the backbone. Finally, glycomacromolecules are tested in a bacterial adhesion inhibition study against Escherichia coli where more hydrophobic backbones yield higher inhibitory potentials most likely due to additional secondary interactions with hydrophobic regions of the protein receptor as well as a change in conformation exposing carbohydrate ligands for increased binding. Overall, the results highlight the influence and thereby importance of the polymer backbone itself on the resulting properties of polymeric biomimetics. 相似文献
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M. Sc. Frederik Kramm M. Sc. Johannes Teske M. Sc. Franziska Ullwer Wolfgang Frey Prof. Dr. Bernd Plietker 《Angewandte Chemie (International ed. in English)》2018,57(40):13335-13338
Cationic Fe complexes of the general type [(Ph3P)2Fe(CO)(NO)]X (X=BF4, BArF4) catalyze the redox‐neutral cycloisomerization of 1,6‐ and 1,7‐enyneacetates to afford bicyclic cyclobutanes under mild conditions in good yields and diastereoselectivities. 相似文献