Exponentially fitted discontinuous Galerkin schemes for singularly perturbed problems

New discontinuous Galerkin schemes in mixed form are introduced for symmetric elliptic problems of second order. They exhibit reduced connectivity with respect to the standard ones. The modifications in the choice of the approximation spaces and in the stabilization term do not spoil the error estimates. These methods are then used for designing new exponentially fitted schemes for advection dominated equations. The presented numerical tests show the good performances of the proposed schemes. © 2011 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2011     

Fighting cancer with translation inhibitors: a quantum mechanics view on the complex between the antitumor marine alkaloid agelastatin A and the yeast 80S ribosome

Structural Chemistry - The alkaloid agelastatin A (AGA) has raised great interest for its potent antitumor activity and intriguing molecular structure. This led to multifarious total syntheses and...     

New HPLC method for in vitro dissolution study of antihypertensive mixture amlodipine and perindopril using an experimental design

A new HPLC method was developed for the determination of amlodipine and perindopril in their binary mixture as a part of a routine control of combined formulations. For the first time an HPLC method was used for an in vitro dissolution study of tablets containing the above drugs. The presented method was validated to meet official requirements and this validation included specificity, stability, linearity, precision and accuracy. Chromatography was carried out using a LiChrospher RP-18 column, a mixture containing acetonitrile and phosphate buffer of pH 3.0 (50:50, v/v) as mobile phase and UV detection at 225 nm. The dissolution test was performed using 900 mL of phosphate buffer at pH 5.5 containing 1% cetylpyridini chloride (CPC) at 37°C and 75 rpm, using the paddle method. Robustness procedure was done according to the plan defined by the Plackett-Burman design. The effects of acetonitrile content, pH of the buffer and flow rate of the mobile phase, column temperature, pH and CPC content in the dissolution medium as well as rotation speed of the paddle were considered. After that, both graphical and statistical methods were used for identification of significant and non-significant effects.      

Influence of the Regression Technique on the Extrapolated Retention Values of Single-Point Adsorption Compounds on Silica Gel

JPC – Journal of Planar Chromatography – Modern TLC - The retention (RM) values of nine one-point adsorption model compounds: diphenylamine, indol, 2-naphtol, 1-naphtol, 1-naphtylamine,...