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The application of hydrolases in organic solvents for synthetic purposes is a procedure routinely adopted in organic chemistry, especially for the preparation of chiral building blocks. Numerous studies have shed light on several aspects of the mechanism of hydrolase action in low-water environments. Procedures suitable to improve the catalytic efficiency of enzymes and productivity of the synthetic processes have been reported. These fundamental and applied investigations have made hydrolase-catalyzed reactions in organic solvents of industrial interest. In this article we describe and discuss various approaches adopted to optimize the performance of hydrolases in organic media, with special emphasis on the formulation of the biocatalysts which, under proper conditions, can display an activity equal to that displayed in aqueous buffers. 相似文献
106.
J. Mispelter A. Croisy P. Jacquignon A. Ricci C. Rossi F. Schiaffela 《Tetrahedron》1977,33(18):2383-2387
The synthesis from 3-thiochromanone of indole and quinoline derivatives is reported. The structures of the compounds obtained, which are analogs of carcinogenic nitrogen polycycles, were determined by means of mass spectrometry and high resolution NMR spectrometry. In the latter case, Nuclear Overhauser Enhancements (NOE) allow the unequivocal determination of structures. Furthermore, direct (or“through space”) 1H-1H couplings are reported and related to the NOE. 相似文献
107.
Giorgio Abbiati Alessandro Cirrincione de CarvalhoElisabetta Rossi 《Tetrahedron》2003,59(37):7397-7402
The cycloaddition reactions of 1-p-tolyl and 1-benzyl- 2,4-diphenyl-1,3-diazabuta-1,3-dienes with a variety of aryl and alkyl isocyanate and isothiocyanate are described. The reaction mechanism is also discussed. 相似文献
108.
Photodegradation of Polychlorinated Dibenzo-p-dioxins in Liquid Samples by Near UV Light Irradiation
Photodegradation of 1,2,3,4-tetrachlorodibenzo-p-dioxin (1,2,3,4-TCDD) in hexane solution was studied under controlled near-UV light exposure in the spectral region from 325 to 269 nm. GC-MS was used to detect the amount of unreacted dioxin and to characterize the relevant degradation products. Irradiation experiments carried out at a constant light energy (700 mJ) showed that the percentage of 1,2,3,4-TCDD left in the solution after irradiation changed from about 55 to 75%, with a minimum of 55% at 310 nm. Further irradiation experiments carried out at two wavelengths, namely 310 and 269 nm, and light energy ranging from 0 to 4000 mJ, showed that the photodegradation reaction of the TCDD always followed a pseudo-first-order kinetic, with a rate constant of 8 × 10−4and 5 × 10−4mJ−1, respectively. These experiments also showed that trichloro- and dichloro-dibenzo-p-dioxins were produced with less than 15% of the initial quantity of TCDD, leading to the conclusion that the dechlorination process is a minor photolysis pathway. 相似文献
109.
Cubadda F 《Journal of AOAC International》2004,87(1):173-204
Inductively coupled plasma-mass spectrometry (ICP-MS) has definitely emerged as a powerful technique for total element determination and as a sensitive and selective detector in hyphenated methods for speciation analyses of elements in foods. In this review, the analytical challenges of elemental analysis of food and agricultural matrixes are discussed and several applications are examined. Selected examples illustrate the analytical approaches being used so far to address specific issues in various areas of food and nutrition research. The applications discussed include studies on dietary intake, element metabolism in man, transfer of elements through the food chain, effects of food processing and domestic preparation, and authenticity and origin assessment. The use of ICP-MS in the field of analytical quality assurance, food control, evaluation of food contact materials, and radionuclide contamination is also examined. Finally, the hyphenated techniques with ICP-MS detection used for elemental speciation in food are reviewed, and an overview of the main applications currently in the literature is presented. Throughout, recent trends and analytical developments likely to have a major impact on food-related areas are highlighted. 相似文献
110.
Muzzalupo R Trombino S Iemma F Puoci F La Mesa C Picci N 《Colloids and surfaces. B, Biointerfaces》2005,46(2):78-83
Vesicular formulations (liposomes and niosomes) play an increasingly important role since they can be used as drug delivery and targeting systems. We described the formation of two niosomal systems based on synthetic bolaform surfactants (4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecanedioc acid diamide (BD-16) and alpha,omega-(4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecane (BC-16). Systems containing BD-16 or BC-16 and different amount of cholesterol (CH) were prepared by aqueous dispersion of films, followed by examination of methylene blue (MB) entrapment, particle size and morphology. Indeed, we also studied the hydration in the distilled water and physiological solution, in order to investigate the complexing ability on vesicle formation. The results obtained in this study show a high encapsulation capacity and this ability and the size depends on cholesterol content. 相似文献